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A. P. van der Ploeg, A. C. van Akkooi, P. Rutkowski, Z. I. Nowecki, W. Michej, A. Mitra, J. A. Newton-Bishop, M. Cook, I. M. van der Ploeg, O. E. Nieweg, M. F. van den Hout, P. A. van Leeuwen, C. A. Voit, F. Cataldo, A. Testori, C. Robert, H. J. Hoekstra, C. Verhoef, A. Spatz and A. M. Eggermont, “Prognosis in Patients with Sentinel Node-Positive Melanoma Is Accurately Defined by the Combined Rotterdam Tumor Load and Dewar Topography Criteria,” Journal of Clinical Oncology, Vol. 29, No. 16, 2011, pp. 2206-2214. http://dx.doi.org/10.1200/JCO.2010.31.6760

has been cited by the following article:

• TITLE: The Prognostic Value of Minimally Involved Melanoma Sentinel Lymph Nodes

  AUTHORS: Alend Saadi, Didier Roulin, Essia Saiji, Hanifa Bouzourene, Nicolas Demartines, Maurice Matter

  KEYWORDS: Metastatic Melanoma; Sentinel Node; Minimally Involved

  JOURNAL NAME: Journal of Cancer Therapy, Vol.4 No.10, December 25, 2013

  ABSTRACT: Background: Sentinel node (SLN) status is the most important prognostic factor for early-stage melanoma patients. It will influence follow-up and may change therapy. Positive SLNs present different degrees of involvement so that subgroups of patients may have minimal SLN invasion. The aim of this study was to evaluate survival in subgroups with minimally involved SLNs and to compare them to negative SLN patients. Method: SLN biopsy was performed in 499 consecutive clinically N0 patients between 1997 and 2008. Following updated recommendations from the Melanoma Group of the European Organization of Research and Treatment of Cancer, degrees of SLN involvement were fully reassessed for two anatomopathological parameters: tumour burden according to Rotterdam criteria (1.0 mm) and microanatomic location according to Dewar (subcapsular, combined subcapsular and parenchymal, parenchymal, multifocal, or extensive). Minimally involved SLNs were defined as those with tumor burden Results: Out of 499 clinically N0 patients, positive SLNs were found in 123 patients (24.7 percent). With a median follow-up of 52 months (range: 9 - 146), five-year disease-free (DFS), disease-specific survival (DSS) and overall survival (OS) were 88.1, 93.9 and 89.9 percent for negative SLN patients, respectively. In minimally involved SLNs, there were 21 with tumour burden Conclusion: Rotterdam’s tumour burden stratification is an easy and useful prognostic factor of melanoma survival. There was a trend showing that patients with SLN tumour burden