TITLE:
Pre-Chelates, Post-Adducts and Implexes: A perspective proposal for the future of medicinal chemistry
AUTHORS:
Mario Gosalvez
KEYWORDS:
New Chelates and Adducts; Embracing Metals, Future of Medicinal Therapeutics; Quelamycin; Thioproli
JOURNAL NAME:
Advances in Biological Chemistry,
Vol.3 No.6,
December
19,
2013
ABSTRACT: The title of this little assay coins three new words: Pre-Chelates, Post-Adducts and Implexes.
These, very daring new excursions into the scientific English language,
come from the developments of Quelamycin and Sodium L-Thioproline, through our
different group studies arriving to cancer reversal by a dual strategy. It is
enough to read all our published materials, cites and related papers, dealing
more or less with the chemistry and possible mechanism of action of these compounds,
to gather somewhat what signified our monomeric-triferric-doxorubicine, as possibly
one of the first Pre-Chelates and our Sodium L-Thioproline, probably as one of
the first Post-Adducts. Both molecules come to the human patients with cancer
blood from the exterior. After this indication, it will be proposed a seed
concept of a new type of molecules, the “Implexes” in which the metals will be
embraced instead of being linked.