TITLE:
Cationic polypeptides in a concept of oppositely charged polypeptides as prevention of postsurgical intraabdominal adhesions
AUTHORS:
Karolin Isaksson, Daniel Åkerberg, Katarzyna Said, Bobby Tingstedt
KEYWORDS:
Postoperative adhesions, bioactive polypeptides, molecular structure
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.4 No.3,
March
8,
2011
ABSTRACT: Background: Two differently charged polypeptides, α-poly-L-lysine and poly-L-glutamate, have previously been shown to effectively reduce postoperative intraabdominal adhesions. Though α-poly-L-lysine showed toxicity in doses too close to the lowest therapeutic dose, the aim in the present study was to investigate the possible antiadhesive effect of another four cationic polypeptides.
Materials/Methods: 125 mice were studied with a standardized and reproducible adhesion model and given epsilon poly-L-lysine, lactoferrin, lysozyme and polyarginine respectively in a combination with poly-L-glutamate. Epsilon poly-L-lysine was also tested in different concentrations and as single treatment.
Results: All four cationic polypeptides above showed a significantly better anti-adhesive effect than the controls receiving saline (p