TITLE:
The genome of herpes simplex virus type 1 is prone to form short repeat sequences
AUTHORS:
Xiangyan Zhao, Xiaolong Wu, Lv Qin, Zhongyang Tan, Shifang Li, Qingjian Ouyang, You Tian
KEYWORDS:
Simple Sequence Repeat; HSV-1 Genome; Microsatellite; SSR
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.1 No.3,
December
12,
2013
ABSTRACT: Herein, we report
a very high content of simple sequence
repeats (SSRs) covering 66.12% of the herpes
simplex virus type 1 (HSV-1) genome when a low threshold is adopted to
define SSRs, indicating that repeat sequence is a very important character of
the HSV-1 genome. The repeats with two iterations account for 68.33% of the total repeats. In reality,
the genome of HSV-1 is prone to form shorter repeat sequences. For mono-, di- and trinucleotide
repeats, the repeat numbers decreased with the increase of repeats iterations, implicating that the
formation tendency
of SSRs might be from low iterations to high iterations. The high iterations
SSRs might have subjected
to strong selected pressure and survived to perform different functions. The
analysis suggested that the repeats formation may be an essential evolutionary driving force for the HSV-1
genome, and the results might be helpful for studying the genome structure,
repeats genesis and genome evolution of HSV-1.