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van Vliet, S.J., van Liempt, E., Saeland, E., Aarnoudse, C.A., Appelmelk, B., Irimura, T., Geijtenbeek, T.B., Blixt, O., Alvarez, R., van Die, I. and van Kooyk, Y. (2005) Carbohydrate profiling reveals a distinctive role for the C-type lectin MGL in the recognition of helminth parasites and tumor antigens by dendritic cells. International Immunology, 17, 661-669. http://dx.doi.org/10.1093/intimm/dxh246

has been cited by the following article:

• TITLE: Seasonal modulation of the C-type lectin MGL on human DCs

  AUTHORS: Ilaria Grazia Zizzari, Chiara Napoletano, Aurelia Rughetti, Hassan Rahimi, Marianna Nuti

  KEYWORDS: MGL; Dendritic Cells; C-Type Lectin

  JOURNAL NAME: Open Journal of Immunology, Vol.3 No.4, December 12, 2013

  ABSTRACT: The C-type lectin MGL is a pathogen recognition receptor, expressed by dendritic cells (DCs) and macrophages (Mfs), able to bind GalNAc (Tn) carrying structures. This receptor also recognized Tn-TAAs that were internalized, processed and presented by DCs to T cells and it acted as an adjuvant on DCs, highlighting its possible application in anti-cancer vaccination. In this work, we found that this receptor present a seasonal modulation: its expression is higher in winter rather than in summer. The percentage of MGL+ donors displayed a negative trend that dropped to 33% during the summer and increased up to 100% in winter. This modulation could be also ascribed to the circa-annual variation of glucocorticoids, in fact MGL is up-regulated in presence of dexamethasone in vitro. The seasonal variation of this receptor could be an important point in the field of tumor vaccination strategies.