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Nakamura, T., Suzuki, H., Wada, Y., Kodama, T and Doi, T. (2006) Fucoidan induces nitric oxide production via p38 mitogen-activated protein kinase and NF-kappaB-dependent signaling pathways through macrophage scavenger receptors. Biochemical and Biophysical Research Communications, 343, 286-294. http://dx.doi.org/10.1016/j.bbrc.2006.02.146

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• TITLE: Maleylated-BSA induces TNF-α production through the ERK and NF-κB signaling pathways in murine RAW264.7 macrophages

  AUTHORS: Rui Tada, Yusuke Koide, Mitsuaki Yamamuro, Akira Hidaka, Koichiro Nagao, Yoichi Negishi, Yukihiko Aramaki

  KEYWORDS: Maleylated-BSA; ERK; Macrophages; Signaling Pathway; TNF-α

  JOURNAL NAME: Open Journal of Immunology, Vol.3 No.4, December 11, 2013

  ABSTRACT: Ligands for macrophage scavenger receptors are reported to induce a wide range of host cell responses, including the production of inflammatory cytokines; however, the underlying mechanisms have not yet been fully understood and which remain obscure. In this study, we have examined the effect of maleylated bovine serum albumin (maleylated-BSA), a well-known ligand of the scavenger receptor, on the murine macrophage cell line RAW264.7. Maleylated-BSA strongly induced the production of tumor necrosis factor-α (TNF-α) and induced phosphorylation of extracellular signal-regulated kinase (ERK) and NF-kB p65. We also observed that maleylated-BSA-induced TNF-α production was blocked by the ERK inhibitor U0126. Together, these data demonstrates that maleylated-BSA- induced production of TNF-α requires the ERK/NF-κB signaling cascade in murine RAW- 264.7 macrophages.