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Mahler, G., Serra, G., Dematteis, S., Saldana, J., Dominguez, L. and Manta, E. (2006) Synthesis and biological evaluation of simplified mycothiazole analogues. Bioorganic & Medicinal Chemistry Letters, 16, 1309- 1311. doi:10.1016/j.bmcl.2005.11.072

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• TITLE: Reaction of thiocarboxanilide derivatives of 2-phenylimino-3-phenyl-4-thiazolidinone and 1,3-diphenyl-2-thioxo-4-imidazolone with hydrazonoyl halides and active chloromethylene compounds

  AUTHORS: Hamdi M. Hassaneen, Omar A. Miqdad, Nada M. Abunada, Ahmad A. Fares

  KEYWORDS: Hydrazonoyl Halides; 1, 3, 4-Thiadiazoline; Thiazolidinone

  JOURNAL NAME: Natural Science, Vol.3 No.3, March 31, 2011

  ABSTRACT: The potassium salts of thiocarboxanilide of 2- phenylimino-3-phenyl-4-thiazolidinone and 1,3- diphenyl-2-thioxo-4-imidazolone react with hydrazonoyl halides in N,N-dimethylformamide to afford the corresponding 1,3,4-thiadiazoline derivatives. 2-Phenylimino-3-phenyl-4-thiazolidinone reacts with active chloromethylene compounds in N,N-dimethylformamide to give the corresponding thiazolylidenethiazolidin-4-one derivatives. The new compounds were characterized using IR, 1H NMR, 13C NMR and mass spectra.