TITLE:
Preparation and evaluation of a novel antibacterial glass-ionomer cement
AUTHORS:
Leah Howard, Yiming Weng, Ruijie Huang, Yuan Zhou, Dong Xie
KEYWORDS:
Dihalomalealdehydic Acid Derivative; Antibacterial Polymer; S. mutans Viability; Glass-Ionomer Cement; CS
JOURNAL NAME:
Journal of Biomedical Science and Engineering,
Vol.6 No.12,
December
6,
2013
ABSTRACT: A
novel antibacterial glass-ionomer cement has been developed. Compressive strength
(CS) and S. mutans viability were used to evaluate the mechanical
strength and antibacterial activity of the formed cement. Compressive
yield strength (YS), modulus (M), diametral tensile strength (DTS) and flexural
strength (FS) were also determined. All the formulated antibacterial cements
showed a significant antibacterial activity, accompanying with an initial CS
reduction. The effect of the synthesized antibacterial polymer loading was
significant. Increasing loading from 1% to 20% significantly decreased the S. mutans viability from 3% to 50% and
also reduced the initial CS (325 MPa) of the formed cements from 19% to 75%.
The cement with 5% antibacterial polymer loading showed 142 MPa, 6.9 GPa, 224
MPa, 52 MPa, and 62 MPa in YS, M, CS, DTS and FS, respectively, as compared to
170, 7.1, 325, 60 and 87 for the experimental cement without antibacterial
polymer addition and 141, 6.9, 236, 42 and 53 for Fuji II LC. It was also found
that the chlorine-containing antibacterial cement showed better CS values than
the bromine-containing cement, with no significant difference in antibacterial
activity. The antibacterial cement also showed a similar antibacterial activity
to Streptococcus mutans, lactobacillus, Staphylococcus aureus and Staphylococcus epidermidis.
The human saliva did not affect the antibacterial activity of the cement. The
thirty-day aging study indicates that the cements may have a long-lasting
antibacterial function.