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R. Sandulescu, S. Mirel and R. Oprean, “The Development of Spectrophotometric Andelectroanalytical Methods for Ascorbic Acid Andacetaminophen and Their Applications in the Analysis Ofeffervescent Dosage Forms,” Journal of Pharmaceutical and Biomedical Analysis, Vol. 23, No. 1, 2000, pp. 77-87. http://dx.doi.org/10.1016/S0731-7085(00)00277-6

has been cited by the following article:

• TITLE: Electrochemical Synthesis of Titanium Nano Particles at Carbon Paste Electrodes and Its Applications as an Electrochemical Sensor for the Determination of Acetaminophen in Paracetamol Tablets

  AUTHORS: K. J. Gururaj, B. E. Kumara Swamy

  KEYWORDS: Titania Nano Particles; Electrochemical Sensor; Electrocatalysis; Cyclic Voltammetry; Electrochemical Impedance Spectroscopy

  JOURNAL NAME: Soft Nanoscience Letters, Vol.3 No.4A, December 4, 2013

  ABSTRACT: Titania nano particles were synthesized at carbon paste electrode by cyclic voltammetry and then it was employed for the determination of acetaminophen in phosphate buffer at pH 7.4. Carbon paste electrode with titania nano particle displayed excellent electrochemically catalytic activities by shifting the oxidation potential of acetaminophen towards the negative side. The mass transfer process at electrochemical interface was diffusion controlled. Electrochemical techniques such as, electrochemical impedance spectroscopy (EIS) and potentiodynamic polarization methods were used to measure the resistance of the electrodes. The resistance of the titanium electrode decreased in two orders when compared to the bare carbon paste electrode; the decrease in the resistance of the electrode and increase in the surface area of the electrode are responsible for the negative shifting of the oxidation potential of acetaminophen. The present method was applied to the determination of actetaminophen in paracetamol tablet, urine and blood sample by using standard addition method and the obtained results were satisfactory with a good recovery of 98%.