TITLE:
Genetic expression of Col-2A and Col-10A as a function of administration of IGF-1 & TGF-β with and without anterior mandibular repositioning appliance on the growth of mandibular condylar cartilage in young rabbit
AUTHORS:
A. S. Patil, R. B. Sable, R. M. Kothari, P. Nagarajan
KEYWORDS:
Transforming Growth Factor-β (TGF-β); Insulin-Like Growth Factor (IGF-1); Condylar Cartilage Growth; Mandibular Repositioning Appliances; Col-2A; Col-10A
JOURNAL NAME:
Open Journal of Stomatology,
Vol.3 No.9A,
December
4,
2013
ABSTRACT: New Zealand (NZ) young rabbits with the administration
of insulin-like growth factor (IGF-1) and transforming growth factor-β (TGF-β) with and without mandibular anterior repositioning appliances
are explored for the growth of the mandibular condylar cartilage (MCC). 32 growing NZ and rabbits were divided into 4
groups: the group with saline injection in TMJ, the group which received growth
factor injection in TMJ, the group which received anterior positioning appliance and the group which received growth
factors injection as well as mandibular repositioning appliance. Gene
expression was studied by real-time RT-PCR and cartilage growth by histomorphometry. Administration of growth factors along with
mandibular repositioning appliances has induced 1) 1.70-fold expression
of Col-2Agene (p value 10A gene (p value growth
factors along with mandibular repositioning appliances causes an increase in
genetic expressions which have been corroborated by histomorphometry and
validated by statistical analysis, during an accelerated growth of mandibular
condylar cartilage. Administration of growth factors in the TMJ could provide
a synergistic role along with mandibular repositioning appliances for treatment
of mandibular retrognathism as well as disorders on the MCC.