TITLE:
Relationship between acute high altitude response, cardiac function injury, and high altitude de-adaptation response after returning to lower altitude*
AUTHORS:
Shengyue Yang, Qiquan Zhou, Zifu Shi, Enzhi Feng, Ziqiang Yan, Zhongxin Tian, He Yin, Yong Fan
KEYWORDS:
Acute High Altitude Response; Cardiac Function; Cardiac Structure; Myocardial Enzyme; Return to Lower Altitude; High Altitude De-Adaptation
JOURNAL NAME:
Occupational Diseases and Environmental Medicine,
Vol.1 No.1,
November
29,
2013
ABSTRACT: The relationship between acute high altitude response (AHAR), cardiac function injury, and high altitude de-adaptation response (HADAR) was assessed. Cardiac function indicators were assessed for 96 men (18 - 35 years old) deployed into a high altitude (3700 - 4800 m) environment requiring intense physical activity. The subjects were divided into 3 groups based on AHAR at high altitude: severe AHAR (n = 24), mild to moderate AHAR (Group B, n = 47) and non-AHAR (Group C, 25); and based on HADAR: severe HADAR (Group E, n = 19), mild to moderate HADAR (Group F, n = 40) and non-HADAR (Group G, n = 37) after return to lower altitude (1,500 m). Cardiac function indicators were measured after 50 days at high altitude and at 12 h, 15 days, and 30 days after return to lower altitude. Controls were 50 healthy volunteers (Group D, n = 50) at 1500 m. Significant differences were observed in cardiac function indicators among groups A, B, C, and D. AHAR score was positively correlated with HADAR score (r = 0.863, P