TITLE:
Intussusception in Japanese infants: Analysis of health insurance claims database
AUTHORS:
Masayoshi Miura, Keiko Sato, Hisao Muto, Kusuma Gopala, Katsiaryna Holl
KEYWORDS:
Hospitalized; Incidence; Intussusception; Japan; Rotavirus
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.3 No.4,
November
27,
2013
ABSTRACT: In order to better understand the possible impact of
second-generation rotavirus vaccines on the incidence of intussusception (IS),
robust knowledge of the baseline childhood
epidemiology of IS from various sources is essential. This study
estimated the overall and agespecific baseline incidence of IS among young Japanese
children. Data on 57 IS cases from 42,438 screened children aged less than 12
months, born between January 2005 and April 2011 and covered by the health
insurance claims database were retrospectively extracted (NCT01479491). IS
cases were identified using the International Classification of Diseases, 10th revision (K56.1), with relevant examination and procedural codes. The extracted
data were used to estimate the incidence of IS. Among all IS cases extracted,
51 (94.4%) were confirmed IS, of which 49/51 (96.1%) were hospitalized, 2/51
(3.9%) visited outpatient wards; 26/51 (51.0%) were males. The overall
incidence of confirmed IS and IS hospitalizations among children aged less than
12 months was 143.5 (95% CI: 106.8 - 188.6) and 137.8 (95% CI: 102.0 - 182.2)
per 100,000 children-years, respectively. Three (5.9%) IS cases were identified
in children aged below 3 months. IS cases peaked between 6 - 11 months of age
(40/51 [78.4%]) with the highest incidence (321.5 [95% CI: 138.8 - 633.4] per
100,000 children-years) observed at 10 months of age. The overall recurrence
rate of IS was 3.7% (95% CI: 0.5 - 12.7). The baseline incidence of IS in
Japanese children aged less than 12 months was higher than that observed in
other countries prior to the introduction of second-generation rotavirus vaccines.