TITLE:
RNase L Variants Do Not Appear to Impact on Clinical Features of Sporadic Prostate Cancer Patients
AUTHORS:
Frank T. D’Arcy, Ruth Foley, Thomas H. Lynch
KEYWORDS:
RNase L; R462Q; D541E; Prostate Cancer
JOURNAL NAME:
Open Journal of Urology,
Vol.3 No.7,
November
27,
2013
ABSTRACT: Introduction: Prostate cancer is the most common non-cutaneous
male cancers, contributing to significant mortality rates globally. Mutations of
RNase L, an enzyme involved in inflammatory and immunological pathways, have been
speculated to predispose to cancer. This study assesses three different mutations
of the RNase L gene in Irish prostate cancer patients, including one linked with
general cancer susceptibility never investigated before in prostate cancer (rs3738579),
and reports on links with aggressive cancer. Methods: 134 patients had their RNase L mutation
status determined by polymerase chain reaction (PCR) of serum DNA. Complementary
clinical details for each patient are statistically analysed. Results: No link to age of
diagnosis, high grade disease or prostate specific antigen (PSA) level at diagnosis
was demonstrated with any of the studied single nucleotide polymorphisms (SNP).
The SNP variation was consistent with that of published international series. Conclusion: SNP genotypic frequencies
in Ireland are consistent with international findings. The studied RNase L mutations
including rs3738579 do not appear to have a significant impact on our patient population.