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S. J. Garalei, K. A. McPhillips, S. C. Frasch, et al., “Cell Surface Calreticulin Initiates Clearance of Viable or Apoptotic Cells through Transactivation of LRP on Phagocyte,” Cell, Vol. 123, No. 2, 2005, pp. 321-334. http://dx.doi.org/10.1016/j.cell.2005.08.032

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• TITLE: Efferocytosis in Retinoblastoma

  AUTHORS: Dipankar Das, Harsha Bhattacharjee, Kasturi Bhattacharjee, Prerana S. Tahiliani, Pankaj Bhattacharyya, Manabjyoti Barman, Sumita Sarma Barthakur, Panna Deka, Apurba Deka, Rajashree Paul

  KEYWORDS: Retinoblastoma; Apoptosis; Efferocytosis; Vesicles; Undifferentiated

  JOURNAL NAME: Journal of Cancer Therapy, Vol.4 No.9, November 25, 2013

  ABSTRACT: Retinoblastoma has varied presentations. As age advances in retinoblastoma, the undifferentiated tumour is the common appearance. Apoptosis in retinoblastoma in an untreated case can give us a clue about the tumour biology. Efferocytosis in intraocular tumour is a new concept which was seen in an enucleated eyeball specimen in a 4-year-old boy. Effective efferocytosis can be conceptualized for new pharmacodynamics application for anti-cancer drugs. We present a rare case of retinoblastoma with efferocytosis in retinal pigment epithelium and interesting apoptotic changes.