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Clarke, P.M., Gray, A.M., Briggs, A., Farmer, A.J., Fenn, P., Stevens, R.J., Matthews, D.R., Stratton, I.M. and Holman, R.R. (2004) A model to estimate the lifetime health outcomes of patients with type 2 diabetes: The United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model (UKPDS no. 68). Diabetologia, 47, 1747-1759. http://dx.doi.org/10.1007/s00125-004-1527-z

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• TITLE: A family history of diabetes is not associated with arterial stiffness in non-diabetic Japanese population

  AUTHORS: Hirokazu Uemura, Sakurako Katsuura-Kamano, Miwa Yamaguchi, Mariko Nakamoto, Mineyoshi Hiyoshi, Fusakazu Sawachika, Kokichi Arisawa

  KEYWORDS: Arterial Stiffness; Brachial-Ankle Pulse Wave Velocity; Family History of Diabetes; Cross-Sectional Study

  JOURNAL NAME: Open Journal of Epidemiology, Vol.3 No.4, November 21, 2013

  ABSTRACT: Prevalent diabetes is at high risk for cardiovascular diseases and has a high familial inheritance. However, little is known whether a non-diabetic subject with a family history of diabetes is at high risk for vascular damage or not. The purpose of this study was to evaluate the association between a family history of diabetes and arterial stiffness in adult non-diabetic Japanese population. We analyzed eligible 787 non-diabetic subjects (502 men and 285 women) aged 35-69 years who enrolled in the baseline survey of a cohort study in Tokushima Prefecture, Japan and who underwent a brachial-ankle pulse wave velocity (ba-PWV) measurement. Information on individual life-style characteristics including medical history and treatment for diseases and a first-degree family history of diabetes was obtained through a structured self-administered questionnaire. Analysis of covariance and logistic regression analyses were used to evaluate the association between a family history of diabetes and ba-PWV. We found no differences in age-and-systolic blood pressure-adjusted and multivariate-adjusted means of ba-PWVs between subjects of both sexes with and without a family history of diabetes. Logistic regression analyses including both sexes also revealed that subjects with a family history of diabetes showed no differences in age-and-systolic blood pressure-adjusted and multivariate-adjusted odds ratios for high ba-PWV compared to those without that trait. Our results suggest that a family history of diabetes itself is not associated with arterial stiffness in adult non-diabetic Japanese population.