TITLE:
Is there a connection between synthetic bone grafts and sisters chromatide exchange?
AUTHORS:
Banu Gürkan Köseoğlu, Amila Brkić, Mehmet ali Erdem, Şükrü Öztürk, Şükrü Palanduz, Kivanç Çefle
KEYWORDS:
Bone Graft; Sisters Chromatide Exchange; Genotoxic; Bone Defect
JOURNAL NAME:
Open Journal of Stomatology,
Vol.3 No.8,
November
18,
2013
ABSTRACT: Background:
In oral and maxillofacial surgery, synthetic bone grafts are most widely used
as bone substitutes, due to the limited sources of autologous bone. The aim of
this study was to examine the influence of three different synthetic bone grafts
(Cerasorb, Fortoss and Perioglass) on sisters chromatide exchanges (SCEs) in peripheral
lymphocytes. Materials and Methods: Peripheral blood samples taken from 68 patients
(45 females and 23 males), who underwent oral surgery procedures, such as apical
resection, cyst enucleation or periodontal curretage, were obtained for SCE a day
before and two months after the surgeries. A control group included 30 patients,
while the study group was made of the patients who underwent bone grafting with
Cerasorb? (11 patients), Fortoss? VITAL (10 patients) or Perioglass? (17 patients). Results: Comparing with the results of the study group before and
after the treatment, it was concluded that the results were statistically significant
(p = 0.001). In the Perioglass? subgroup, a greater statistical significance (p = 0.003) was noted, than that in either the Cerasorb? (p = 0.620)
or Fortoss? (p = 0.210) subgroups, in which there was no statistical
significance. Conclusions: Although further investigations may be necessary, our
results suggest that the synthetic bone grafts might have an influence on SCE in
peripheral lymphocytes.