TITLE:
The Association of Psychological Stress Related Cytokines (TNF Alpha, IFN-Gamma) with Essential Hypertension in Ningxia Hui Autonomous Region
AUTHORS:
Zhaodi Niu, Jian Zhou, Wenwu Ji, Haixia Li, Dan Bai, Huifang Yang
KEYWORDS:
Essential Hypertension; Psychological Stress; TNF Alpha; IFN-Gamma
JOURNAL NAME:
Open Journal of Endocrine and Metabolic Diseases,
Vol.3 No.7,
November
18,
2013
ABSTRACT: The study aimed to explore the association between psychological
stress-related cytokines and essential hypertension to provide the theoretical
basis for the prevention and control of the essential hypertension. We screened hypertension patients in
six communities in Wuzhong City of Ningxia, and chose the healthy people who
had lived in the same community for full 5 years as a control group. Finally, we selected 210
pairs of cases and controls randomly, including 108 pairs of Hui and 102 pairs of Han (50% male; age 35 -74). The results showed that the serum
TNF alpha levels of hypertension group were higher
than the control group (ρ 0.01), and
the serum IFN-gamma levels were lower than the control group both in Hui
and Han (ρ 0.01). Further
analysis showed that the serum TNF alpha level of the Hui hypertension group was
higher than the Han hypertension group (ρ 0.01), while
the serum IFN-gamma level was lower than Han hypertension group (ρ 0.01).
In conclusion, TNF alpha and IFN-gamma were the important related cytokines
between psychological stress and
hypertension, and taking effective measures to control the level of serum TNF alpha. IFN-gamma may have the vital significance in alleviating or
preventing the genesis and development of essential hypertension.