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R. V. Lloyd, L. Jin, A. Chang, et al., “Morphologic Effects of hGRH Gene Expression on the Pituitary, Liver, and Pancreas of MT-hGRH Transgenic Mice. An in Situ Hybridization Analysis,” American Journal of Pathology, Vol. 141, No. 4, 1992, pp. 895-906.

has been cited by the following article:

• TITLE: A Case of Ectopic Growth Hormone Releasing Hormone (GHRH) from Pancreatic Neuroendocrine Tumor Resistant to Therapy

  AUTHORS: Ohoud Almohareb, Juan Rivera

  KEYWORDS: Ectopic GHRH; Acromegaly; Pancreatic Neuroendocrine Tumor

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.3 No.7, November 18, 2013

  ABSTRACT: Introduction: Ectopic secretion of GHRH is a rare cause of acromegaly. However, its recognition is clinically important because different therapeutic approaches are required. Case Presentation: We present a challenging case of acromegaly secondary to ectopic GHRH secretion from pancreatic neuroendocrine tumor in a 52-year-old female. The patient is treated with different modalities which include pegvisomant in an attempt to control the stimulated GH-axis considering the limited data about its use in treatment of ectopic acromegaly. Conclusion: GHRH-secreting tumor is a rare cause of acromegaly. Surgical resection of the tumor is the therapy of choice whenever possible. However, further studies are warranted for unresectable tumor or resistant cases.