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R. T. Jensen, M. J. Berna, D. B. Bingham, et al., “Inherited Pancreatic Endocrine Tumor Syndromes: Advances in Molecular Pathogenesis, Diagnosis, Management and Controversies,” Cancer, Vol. 113, Suppl. 7, 2008, pp. 1807-1843. http://dx.doi.org/10.1002/cncr.23648

has been cited by the following article:

• TITLE: A Case of Ectopic Growth Hormone Releasing Hormone (GHRH) from Pancreatic Neuroendocrine Tumor Resistant to Therapy

  AUTHORS: Ohoud Almohareb, Juan Rivera

  KEYWORDS: Ectopic GHRH; Acromegaly; Pancreatic Neuroendocrine Tumor

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.3 No.7, November 18, 2013

  ABSTRACT: Introduction: Ectopic secretion of GHRH is a rare cause of acromegaly. However, its recognition is clinically important because different therapeutic approaches are required. Case Presentation: We present a challenging case of acromegaly secondary to ectopic GHRH secretion from pancreatic neuroendocrine tumor in a 52-year-old female. The patient is treated with different modalities which include pegvisomant in an attempt to control the stimulated GH-axis considering the limited data about its use in treatment of ectopic acromegaly. Conclusion: GHRH-secreting tumor is a rare cause of acromegaly. Surgical resection of the tumor is the therapy of choice whenever possible. However, further studies are warranted for unresectable tumor or resistant cases.