TITLE:
Evaluation of Antibacterial and Antidiarrhoeal Activities of Feronia limonia Leaf Extract
AUTHORS:
Mohammad Abdul Motalib Momin, Mizanur Rahaman Khan, Johir Rayhan, Afrina Afrose, Sohel Rana, Anjuman Ara Begum
KEYWORDS:
Phytochemical Screening; Antimicrobial; Antidiarrhoeal; Feronia limonia
JOURNAL NAME:
American Journal of Plant Sciences,
Vol.4 No.11,
November
14,
2013
ABSTRACT: The present study was carried out to investigate possible antibacterial
and antidiarrhoeal activities of ethanol extract of Feronia limonia leaves. Phytochemical analysis of the crude extract
was performed to detect presence of different kinds of phytoconstituents. The antibacterial
activity was investigated against four Gram positive and four Gram negative
bacteria by using disc diffusion method.
The plant extract showed moderate antibacterial activity against Gram positive
bacteria namely Staphylococcus saprophyticus and Staphylococcus
pyogenes and all tested Gram negative bacteria namely Escherichia coli, Shigella boydii, Shigella dysentery
and Shigella flexneri in dose dependant manner. The results of
castor oil-induced diarrhoeal study showed that Feronia limonia extract significantly reduced the severity &
frequency of diarrhoea in mice at a higher dose of 500 mg/kg compared with the
standard drug loperamide (25 mg/kg). The
present study clearly supports the medicinal value of this plant. The overall
results indicate the possibility of presence of some active
principles in the plant extract possessing antibacterial and antidiarrhoeal
actions.