Prof. Mehnaz Gharaee-Kermani

Medical School

The University of Michigan, USA

Email: [email protected]

Qualifications

1999 Postdoctoral Fellowship. The University of Michigan, Medical School, Pathology

1996 Ph.D. The University of Michigan, Epidemiology Science

Publications (Selected)

1. Gheinani, A. H., Sack, B. S., Bigger-Allen, A., Thaker, H., Atta, H., Lambrinos, G., ... & Adam, R. M. (2025). Multiomics analysis unveils an inosine-sensitive DNA damage response in neurogenic bladder after spinal cord injury. JCI insight.
2. Klein, B., Reynolds, M. B., Xu, B., Gharaee-Kermani, M., Gao, Y., Berthier, C. C., ... & Kahlenberg, J. M. (2024). Epidermal ZBP1 stabilizes mitochondrial Z-DNA to drive UV-induced IFN signaling in autoimmune photosensitivity. bioRxiv.
3. Hwang, A. S., Kechter, J. A., Do, T. H., Hughes, A. N., Zhang, N., Li, X., ... & Mangold, A. R. (2025). Rapid response of lichen planus to baricitinib associated with suppression of cytotoxic CXCL13+ CD8+ T cells. The Journal of Clinical Investigation, 135(2).
4. van Drongelen, V., Young, K., Gharaee-Kermani, M., Plazyo, O., Griffin, E., Syu, L., ... & Billi, A. (2024). 016 Investigating therapeutic targeting of the female-biased factor VGLL3 in lupus. Journal of Investigative Dermatology, 144(8), S3.
5. Do, T. H., Wasikowski, R., Xing, X., Gharaee-Kermani, M., Raducu, M., Fox, J., ... & Gudjonsson, J. E. (2024). 069 Single-cell analysis reveals distinct subpopulations of T cells and elevated IL-26 and IL-17 levels in palmoplantar pustulosis lesions. Journal of Investigative Dermatology, 144(8), S13.
6. Plazyo, O., Wasikowski, R., Gharaee-Kermani, M., Tsou, E. P. S., Tsoi, L., Billi, A., ... & Gudjonsson, J. (2024). Targeting Hippo pathway diminishes disease signaling in scleroderma skin. The Journal of Immunology, 212(1_Supplement), 0964_5177-0964_5177.
7. Loftus, S. N., Gharaee-Kermani, M., Xu, B., Moore, T. M., Hannoudi, A., Mallbris, M. J., ... & Kahlenberg, J. M. (2024). Interferon alpha promotes caspase-8 dependent ultraviolet light-mediated keratinocyte apoptosis via interferon regulatory factor 1. Frontiers in Immunology, 15, 1384606.
8. Shoffner-Beck, S. K., Abernathy-Close, L., Lazar, S., Ma, F., Gharaee-Kermani, M., Hurst, A., ... & Kahlenberg, J. M. (2024). Lupus dermal fibroblasts are proinflammatory and exhibit a profibrotic phenotype in scarring skin disease. JCI insight, 9(6), e173437.
9. Uppala, R., Sarkar, M. K., Young, K. Z., Ma, F., Vemulapalli, P., Wasikowski, R., ... & Gudjonsson, J. E. (2024). HERC6 regulates STING activity in a sex-biased manner through modulation of LATS2/VGLL3 Hippo signaling. Iscience, 27(2).
10. Ma, F., Tsou, P. S., Gharaee-Kermani, M., Plazyo, O., Xing, X., Kirma, J., ... & Gudjonsson, J. E. (2024). Systems-based identification of the Hippo pathway for promoting fibrotic mesenchymal differentiation in systemic sclerosis. Nature Communications, 15(1), 210.
11. van Straalen, K. R., Ma, F., Tsou, P. S., Plazyo, O., Gharaee-Kermani, M., Calbet, M., ... & Gudjonsson, J. E. (2024). Single-cell sequencing reveals Hippo signaling as a driver of fibrosis in hidradenitis suppurativa. The Journal of Clinical Investigation, 134(3).
12. Xing, E., Ma, F., Wasikowski, R., Billi, A. C., Gharaee-Kermani, M., Fox, J., ... & Khanna, D. (2023). Pansclerotic morphea is characterized by IFN-γ responses priming dendritic cell fibroblast crosstalk to promote fibrosis. JCI insight, 8(16), e171307.
13. Ma, F., Gharaee-Kermani, M., Tsoi, L. C., Plazyo, O., Chaskar, P., Harms, P., ... & Gudjonsson, J. E. (2024). Single-cell profiling of prurigo nodularis demonstrates immune-stromal crosstalk driving profibrotic responses and reversal with nemolizumab. Journal of Allergy and Clinical Immunology, 153(1), 146-160.
14. Ma, F., Plazyo, O., Billi, A. C., Tsoi, L. C., Xing, X., Wasikowski, R., ... & Gudjonsson, J. E. (2023). Single cell and spatial sequencing define processes by which keratinocytes and fibroblasts amplify inflammatory responses in psoriasis. Nature communications, 14(1), 3455.
15. Loftus, S. N., Liu, J., Berthier, C. C., Gudjonsson, J. E., Gharaee-Kermani, M., Tsoi, L. C., & Kahlenberg, J. M. (2023). Loss of interleukin-1 beta is not protective in the lupus-prone NZM2328 mouse model. Frontiers in Immunology, 14, 1162799.
16. Gharaee-Kermani, M., Billi, A., Martens, J., Hildebrandt, M., Victory, A., Maz, M. P., ... & Gudjonsson, J. (2023). 1530 Overexpression of VGLL3 drives hippo and TGFβ dysregulation and fibrosis in CLE lesions using single-cell RNA sequencing. Journal of Investigative Dermatology, 143(5), S262.

Profile Details

https://medschool.umich.edu/profile/8863/mehrnaz-gharaee-kermani

https://www.linkedin.com/in/mehrnaz-gharaee-kermani-7312053b/

https://www.researchgate.net/profile/Mehrnaz-Gharaee-Kermani