Biography

Dr. Se Bok Jang

College of Natural Science

Pusan National University, KOREA

Professor for Molecular Biology


Email: [email protected], [email protected]


Qualifications

2009 Visiting Fellow, Weill Medical College, Cornell University, USA

2000 Post-Doc., Department of Chemistry and Biochemistry, Utah State University, USA

1998 Post-Doc., Lawrence Berkeley National Lab., University of California, Berkeley, USA

1995 Ph.D., Department of Chemistry, Pusan National University, KOREA


Publications (selected)

  1. Park, Y. H., Han, C. W., Jeong, M. S., & Jang, S. B. (2022). DED interaction of FADD and caspase-8 in the induction of apoptotic cell death. Journal of Microbiology and Biotechnology, 32(8), 1034.
  2. Han, J. H., Kim, M., Kim, H. J., Jang, S. B., Bae, S. J., Lee, I. K., ... & Ha, K. T. (2021). Targeting lactate dehydrogenase A with catechin resensitizes SNU620/5FU gastric cancer cells to 5-fluorouracil. International journal of molecular sciences, 22(10), 5406.
  3. Kim, H. J., Jeong, M. S., & Jang, S. B. (2021). Molecular characteristics of RAGE and advances in small-molecule inhibitors. International journal of molecular sciences, 22(13), 6904.
  4. Lee, H. N., Jeong, M. S., & Jang, S. B. (2021). Molecular characteristics of amyloid precursor protein (APP) and its effects in cancer. International Journal of Molecular Sciences, 22(9), 4999.
  5. Kim, H. J., Lee, H. N., Jeong, M. S., & Jang, S. B. (2021). Oncogenic KRAS: signaling and drug resistance. Cancers, 13(22), 5599.
  6. Kim, H. J., Jeong, M. S., & Jang, S. B. (2021). Structure and activities of the NS1 influenza protein and progress in the development of small-molecule drugs. International Journal of Molecular Sciences, 22(8), 4242.
  7. Han, C. W., Jeong, M. S., & Jang, S. B. (2021). Understand KRAS and the quest for anti-cancer drugs. Cells, 10(4), 842.
  8. Jin, L., Kim, E. Y., Chung, T. W., Han, C. W., Park, S. Y., Han, J. H., ... & Ha, K. T. (2020). Hemistepsin A suppresses colorectal cancer growth through inhibiting pyruvate dehydrogenase kinase activity. Scientific reports, 10(1), 21940.
  9. Chung, T. W., Kim, E. Y., Han, C. W., Park, S. Y., Jeong, M. S., Yoon, D., ... & Ha, K. T. (2019). Machilin A inhibits tumor growth and macrophage M2 polarization through the reduction of lactic acid. Cancers, 11(7), 963.
  10. Han, C. W., Jeong, M. S., & Jang, S. B. (2019). Structure and function of the influenza A virus non-structural protein 1.
  11. Kim, E. Y., Chung, T. W., Han, C. W., Park, S. Y., Park, K. H., Jang, S. B., & Ha, K. T. (2019). A novel lactate dehydrogenase inhibitor, 1-(phenylseleno)-4-(trifluoromethyl) benzene, suppresses tumor growth through apoptotic cell death. Scientific reports, 9(1), 3969.
  12. Park, S. A., Jeong, M. S., Ha, K. T., & Jang, S. B. (2018). Structure and function of vascular endothelial growth factor and its receptor system. BMB reports, 51(2), 73.
  13. Han, C. W., Jeong, M. S., & Jang, S. B. (2017). Structure, signaling and the drug discovery of the Ras oncogene protein. BMB reports, 50(7), 355.
  14. Chung, T. W., Kim, E. Y., Kim, S. J., Choi, H. J., Jang, S. B., Kim, K. J., ... & Ha, K. T. (2017). Sialyllactose suppresses angiogenesis by inhibiting VEGFR-2 activation, and tumor progression. Oncotarget, 8(35), 58152.
  15. Park, S. Y., Jeong, M. S., Han, C. W., Yu, H. S., & Jang, S. B. (2016). Structural and functional insight into proliferating cell nuclear antigen. Journal of microbiology and biotechnology, 26(4), 637-647.
  16. Lee, S. Y., Hwang, E. Y., Seok, H. Y., Tarte, V. N., Jeong, M. S., Jang, S. B. and Moon, Y. H., 2014. Arabidopsis AtERF71/HRE2 functions as transcriptional activator via cis-acting GCC box or DRE/CRT element and is involved in root development through regulation of root cell expansion. Plant cell reports.ISSN 0721-7714.[Epub ahead of print]. Available from: http://dx.doi.org/10.1007/s00299-014-1701-9
  17. Hwang, E. Y., Jeong, M. S., Park, E. K., Kim, J. H.and Jang, S. B., 2014. Structural characterization and interaction of periostin and bone morphogenetic protein for regulation of collagen cross-linking.Biochemical and biophysical research communications,vol. 449, no. 4, pp. 425–431. ISSN 0006-291X. Available from: http://dx.doi.org/10.1016/j.bbrc.2014.05.055
  18. Park, Y. H., Jeong, M. S. and Jang, S. B., 2014. Death domain complex of the TNFR-1, TRADD, and RIP1 proteins for death-inducing signaling.Biochemical and biophysical research communications, vol. 443, no. 4, pp. 1155-1161. ISSN 0006-291X. Available from: http://dx.doi.org/10.1016/j.bbrc.2013.12.068
  19. Hwang, E. Y., Jeong, M. S., Park, S. Y. and Jang, S. B., 2013. Evidence of complex formation between FADD and c-FLIP death effector domains for the death inducing signaling complex.BMB reports, vol. 47, no. 9, pp. 488-493. ISSN 1976-6696.Available from: http://dx.doi.org/10.5483/BMBRep.2014.47.9.239
  20. Hwang, E. Y., Jeong, M. S., Sung, M. and Jang, S. B., 2013. Overexpression and biological characterization of the death domain complex between TRADD and FADD.Bulletin of the Korean Chemical Society, vol. 34, no. 4, pp. 1089-1095. ISSN 0253-2964.Available from: http://dx.doi.org/10.5012/bkcs.2013.34.4.1089
  21. Jeong, M. S., Hwang, H. G., Yu, H. S. and Jang, S. B., 2013. Structure of full-length Toxascarisleoninagalectin with two carbohydrate-recognition domains.ActaCrystallographica Section D: Biological Crystallography, vol. 69, no. 2, pp. 168-175. ISSN 0907-4449.Available from: http://dx.doi.org/10.1107/S0907444912045106
  22. Park, Y. H., Jeong, M. S., Park, H. H. and Jang, S. B., 2013. Formation of the death domain complex between FADD and RIP1 proteins in vitro.BiochimicaetBiophysicaActa (BBA)-Proteins and Proteomics, vol. 1834, no. 1, pp. 292-300. ISSN 1570-9639.Available from: http://dx.doi.org/10.1016/j.bbapap.2012.08.013
  23. Feldman, T., Kabaleeswaran, V., Jang, S. B., Antczak, C., Djaballah, H., Wu, H. and Jiang, X., 2012. A class of allosteric caspase inhibitors identified by high-throughput screening.Molecular cell, vol. 47, no. 4, pp. 585-595.ISSN 1097-2765. Available from: http://dx.doi.org/10.1016/j.molcel.2012.06.007
  24. Park, S. Y., Jeong, M. S. and Jang, S. B., 2012. In vitro binding properties of tumor suppressor p53 with PUMA and NOXA.Biochemical and biophysical research communications, vol. 420, no. 2, pp. ISSN 0006-291X. 350-356. Available from: http://dx.doi.org/10.1016/j.bbrc.2012.03.001
  25. Sung, M., Jeong, M. S., Lee, W. C., Song, J. H., Kim, H. Y., Cho, M. K., Yu, H. S. and Jang, S. B., 2012. Biophysical feature, crystallization and X-ray crystallographic studies of toxascarisleoninagalectin.Bulletin of the Korean Chemical Society, vol. 33, no. 1, pp. 227-232. ISSN 0253-2964.Available from: http://dx.doi.org/10.5012/bkcs.2012.33.1.227
  26. Park, S. Y., Jeong, M. S., Yoo, M. and Jang, S. B., 2011. Caudal-related homeodomain proteins CDX1/2 bind to DNA replication-related element binding factor. BiochimicaetBiophysicaActa (BBA)-Proteins and Proteomics, vol. 1814, no. 12, pp. 1891-1899. ISSN 1570-9639.Available from: http://dx.doi.org/10.1016/j.bbapap.2011.07.021
  27. Park, S. Y., Jeong, M. S. and Jang, S. B., 2011. Binding properties and structural predictions of homeodomain proteins CDX1/2 and HOXD8.Bulletin of the Korean Chemical Society, vol. 32, no. 7, pp. 2325-2331. ISSN 0253-2964.Available from:http://dx.doi.org/10.5012/bkcs.2011.32.7.2325
  28. Jo, B. B., Jeong, M. S., Park, S. Y., Cheong, J. and Jang, S. B., 2011. The binding of hepatitis B virus X protein to glioma-associated oncogene homologue 1 and its biological characterization in vitro.Applied biochemistry and biotechnology, vol. 165, no. 1, pp. 109-122.ISSN 0273-2289.Available from: http://dx.doi.org/10.1007/s12010-011-9237-8
  29. Sung, M., Jeong, M. S. and Jang, S. B., 2010. Biological characterization and structure based prediction of insulin-like growth factor binding protein-5. Biochemical and biophysical research communications, vol. 403, no. 2, pp. 230-236. ISSN 0006-291X. Available from: http://dx.doi.org/10.1016/j.bbrc.2010.11.016
  30. Hwang, E. Y., Jeong, M. S. and Jang, S. B., 2010. Biochemical and biophysical characterizations of the interaction between two PDZ adapter proteins NHERF and E3KARP in vitro.Bulletin of the Korean Chemical Society, vol. 31, no. 11, pp. 3241-3246. ISSN 0253-2964.Available from: http://dx.doi.org/10.5012/bkcs.2010.31.11.3241
  31. Wang, L., Yang, J. K., Kabaleeswaran, V., Rice, A. J., Cruz, A. C., Park, A. Y., Yin, Q., Damko, E., Jang, S. B., Raunser, S., Robinson, C. V., Siegel, R. M., Walz, T. and Wu, H., 2010. The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nature structural & molecular biology, vol. 17, no. 11, pp. 1324-1329.ISSN 1545-9993.Available from: http://dx.doi.org/10.1038/nsmb.1920
  32. Kim, E. J., Jeong, M. S., Hwang, J. R., Lee, J. H. and Jang, S. B., 2010. interaction between IGFBP-5 and TNFR1. Bulletin of the Korean Chemical Society, vol. 31, no. 7, pp. 2019-2024. ISSN 0253-2964.Available from:http://dx.doi.org/10.5012/bkcs.2010.31.7.2019
  33. Jeong, M. S., Kim, E. J. and Jang, S. B., 2010. Expression and RNA-binding of human zinc-finger antiviral protein.Biochemical and biophysical research communications, vol. 396, no. 3, pp. 696-702. ISSN 0006-291X. Available from:http://dx.doi.org/10.1016/j.bbrc.2010.04.164
  34. Jeong, M. S., Hwang, E. Y., Jin, G. E., Park, S. Y., Zulfugarov, I. S., Moon, Y. H., Lee, C. H. and Jang, S. B., 2010. Expression and pH-dependence of the photosystem II subunit S from arabidopsis thaliana.Bulletin of the Korean Chemical Society, vol. 31, no.6, pp. 1479-1484. ISSN 0253-2964.Available from: http://dx.doi.org/10.5012/bkcs.2010.31.6.1479
  35. Ha, J. H., Jeong, M. S., Jo, W. S., Jeong, M. H. and Jang, S. B., 2010. Biological characterization of the Omp1-like Protein from actinobacillusactinomycetemcomitans.Bulletin of the Korean Chemical Society, vol. 31, no. 2, pp. 275-280. ISSN 0253-2964.Available from: http://dx.doi.org/10.5012/bkcs.2010.31.02.275
  36. Jeong, M. S., Hwang, E. Y., Kim, H. T., Yoo, M. A. and Jang, S. B., 2009. Purification of caudal-related homeodomain transcription factor and its binding characterization.Journal of microbiology and biotechnology, vol. 19, no. 12, pp. 1557-1564.ISSN 1017-7825.Available from: http://dx.doi.org/10.4014/jmb.0905.05021
  37. Hwang, E. Y., Jeong, M. S., Cha, J. and Jang, S. B., 2009. Purification and biological characterization of wild-type and mutants of a levanfructotransferase from microbacterium sp. AL-210.Korean Journal of Life Science, vol. 19, no. 9, pp. 1218-1225. ISSN 1225-9918.Available from:http://www.dbpia.co.kr/Article/1085480
  38. Moon, K. O., Choi, K. H., Kang, H. Y., Oh, J. I., Jang, S. B., Park, C. S., Lee, J. H. and Cha, J., 2008. Probing the critical residues for intramolecular fructosyl transfer reaction of a levanfructotransferase.Journal of microbiology and biotechnology, vol. 18, no. 6, pp. 1064-1069.ISSN 1017-7825.Available from: http://www.jmb.or.kr/journal/viewJournal.html?year=2008&vol=18&num=6&page=1064
  39. Park, J. S., Lee, K. M., Jeong, M. S., Jin, G. and Jang, S. B., 2007. The binding of human CLIC1 with SEDL and its characterization in vitro.Bulletin of the Korean Chemical Society, vol. 28, no. 4, pp. 574-580. ISSN 0253-2964.Available from:http://dx.doi.org/10.5012/bkcs.2007.28.4.574
  40. Jeong, M. S., Park, J. S. and Jang, S. B., 2007. Cloning, overexpression, purification, and characterization of receptor-interacting protein 3 truncation inEscherichia coli.Applied biochemistry and biotechnology, vol. 141, no. 2-3, pp. 175-186.ISSN.0273-2289. Available from: http://dx.doi.org/10.1007/BF02729060


Profile Details

https://bk21-bio.pusan.ac.kr/pnuProfl/bk21_bio/1647/15590/artclView.do
https://www.scilit.com/scholars/?q=Se%20Bok%20Jang
https://www.researchgate.net/profile/Se-Jang

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