Prof. Hiroaki Nagano

Department of Gastroenterological, Breast and Endocrine Surgery
Yamaguchi University, Japan

Email: [email protected]

Qualifications

1994 Ph.D., Graduate School of Medicine, Osaka University, Japan

1986 M.D., Okayama University Medical School, Japan

Publications (selected)

1. Umeshita, K., Eguchi, S., Fukumoto, T. and Ohdan, H. Liver Transplantation in Japan: Registry by the Japanese Liver Transplantation Society. Hepatology Research, 2026.
2. Imaoka, H., Ikeda, H., Wakabayashi, M. and Furuse, J. Understanding Polyploid Giant Cancer Cells: From Molecular Mechanisms to Clinical Implications. Preprint, 2026.
3. Okamoto, K., Hijioka, S., Kobayashi, N. and Furuse, J. Efficacy and safety of peptide radionuclide therapy with 177Lu-DOTATATE in Japanese patients with advanced neuroendocrine neoplasm: a multicenter retrospective study (JON2203-N). Journal of Gastroenterology, 2026.
4. Ando, S., Ikeda, S., Tanaka, K. and Ohama, T. Switching of the c-Myc protein degradation pathway depending on the PP2A-B55α complex levels. Proceedings of the National Academy of Sciences, 2026.
5. Terashima, T., Ikeda, H., Yamashita, T. and Nagano, H. A Multicenter Phase II Study on Atezolizumab plus Bevacizumab Combination Therapy in Patients with Unresectable Hepatocellular Carcinoma and Child-Pugh Classification B Cirrhosis: CHALLENGE Trial. Liver Cancer, 2026.
6. Maeda, N., Nagashima, Y., Takasu, H. and Nagano, H. Radiation-Associated Angiosarcoma of the Breast-A Case Report. Gan to kagaku ryoho. Cancer & chemotherapy, 2025.
7. Yamamoto, H., Elbadawy, M., Tsunedomi, R. and Sasaki, K. Novel organoid-based exploration reveals the role of LMTK3/FADS2 signaling in metastatic breast cancer progression in felines and humans. Scientific Reports, 2025.
8. Saeki, I., Suehiro, Y., Yamauchi, Y. and Yamasaki, T. Validation of Liquid Biopsy Using a Methylated SEPT9 Assay and Integrated Index for Detecting Hepatocellular Carcinoma. Hepatology Research, 2025.
9. Ogiso, S., Hatano, E., Seo, S. and Ioka, T. Neoadjuvant Chemotherapy With Gemcitabine/Cisplatin/S‐1 for Resectable Biliary Tract Cancer With FDG‐PET‐Positive Lymph Node Metastasis (KHBO1201): A Multicenter Phase II Trial. Journal of Hepato-Biliary-Pancreatic Sciences, 2025.
10. Shindo, Y., Takahashi, H., Matsui, H. and Nagano, H. Reconsidering Upfront Surgery for Resectable Pancreatic Ductal Adenocarcinoma: The Role of Risk Stratification and Neoadjuvant Chemotherapy. Surgical Oncology, 2025.
11. Yakabe, A., Matsui, H., Shindo, Y. and Nagano, H. A Case of Pancreatic Cancer with Concomitant Pancreatic Metastasis of Renal Cell Carcinoma. Gan to kagaku ryoho. Cancer & chemotherapy, 2024.
12. Imaoka, H., Ikeda, H., Kobayashi, S. and Nagano, H. Efficacy of liposomal irinotecan + 5-FU/LV vs. S-1 in gemcitabine-refractory metastatic pancreatic cancer: a real-world study using inverse probability of treatment weighting. Journal of Gastroenterology, 2024.
13. Sadamori, H., Hasegawa, K., Oba, A. and Endo, I. Short- and long-term outcomes of liver resection with hepatic vein reconstruction for liver tumors: A nationwide multicenter survey. Journal of Hepato-Biliary-Pancreatic Sciences, 2024.
14. Nakashima, C., Iida, M., Nishiyama, M. and Nagano, H. Impact of infectious complications after gastrectomy on non‑gastric cancer‑related deaths. Oncology Letters, 2024.
15. Ohta, K., Sakoda, Y., Adachi, K. and Tamada, K. Therapeutic Efficacy of IL7/CCL19-Expressing CAR-T Cells in Intractable Solid Tumor Models of Glioblastoma and Pancreatic Cancer. Cancer Research Communications, 2024.
16. Akahoshi, K., Shindoh, J., Tanabe, M. and Kokudo, N. Questionnaire survey of Japanese board‐certified expert hepatobiliary and pancreatic surgeons and instructors on the surgical indications for hepatocellular carcinoma. Journal of Hepato-Biliary-Pancreatic Sciences, 2023.
17. Tokumitsu, Y., Kawaoka, T., Harada, E. and Nagano, H. A prospective observational study of laparoscopic approaches for suspected gallbladder cancer in Yamaguchi (YPB-002 LAGBY). Preprint, 2023.
18. Kobayashi, S., Wada, H., Sakai, D. and Ioka, T. Impact of Tumor Shrinkage Pattern with Biweekly Triplet Gemcitabine+Cisplatin+S-1 Regimen for Biliary Tract Cancers: Implications for Neoadjuvant Therapy from the Data of KHBO1401 (KHBO1401-1A Study). Oncology, 2023.
19. Suzuki, N., Shindo, Y., Nakajima, M. and Nagano, H. Current status of vaccine immunotherapy for gastrointestinal cancers. Surgery Today, 2023.
20. Ikenaga, N., Hashimoto, T., Mizusawa, J. and Ueno, M. A multi-institutional randomized phase III study comparing minimally invasive distal pancreatectomy versus open distal pancreatectomy for pancreatic cancer; Japan Clinical Oncology Group study JCOG2202 (LAPAN study). Preprint, 2023.
21. Shindo, Y., Tokumitsu, Y., Nakajima, M. and Nagano, H. Laparoscopic spleen-preserving distal pancreatectomy: A novel technique with splenic artery resection and splenic vein preservation. Asian Journal of Endoscopic Surgery, 2023.
22. Tsunedomi, R., Shindo, Y., Nakajima, M. and Nagano, H. The tumor immune microenvironment in pancreatic cancer and its potential in the identification of immunotherapy biomarkers. Expert Review of Molecular Diagnostics, 2023.
23. Zhang, Y., Zheng, H., Xu, M. and Kobayashi, S. Fyn-Mediated Paxillin Tyrosine 31 Phosphorylation Regulates Migration and Invasion of Breast Cancer Cells. International Journal of Molecular Sciences, 2023.
24. Shindo, Y., Tokumitsu, Y., Matsui, H. and Nagano, H. Efficacy of Staging Laparoscopy in Patients With Pancreatic Cancer: A Single Center Prospective Cohort Study. In Vivo, 2023.
25. Ohta, Y., Akiyama, M., Yodokawa, C. and Nagano, H. A case of MEN1 presenting with multiple pancreatic neuroendocrine tumors with large cyst-like morphology difficult to differentiate from mucinous cystic neoplasm (MCN). Suizo, 2023.

Personal Details

WoS Researcher ID: GCN-3361-2022

https://www.researchgate.net/profile/Hiroaki-Nagano-3