Dr. Devrishi Goswami

The Scripps Research Institute, USA

Email: [email protected]

Qualification

2006 – 2010 PhD in Biochemistry Max Planck Institute of Biophysics, Germany

2002 – 2004 MS in Biotechnology, Pondicherry University, Pondicherry, India

1999 – 2002 BSc in Chemistry, Zoology and Botany, Burdwan University, India

Publications (Selected)

1. Goswami D, Callaway CG, Pascal BD, Edwards DP, Griffin PR (2013) The influence of domain interactions on conformational mobility of the progesterone receptor as detected by hydrogen/deuterium exchange mass spectrometry. Structure 2014 Jun 4. [Epub ahead of print]
2. Kirschke E, Goswami D, Southworth D, Griffin PR and Agard D (2013) Glucocorticoid Receptor Function Regulated by Coordinated Action of the Hsp90 and Hsp70 Chaperone Cycles. Cell 2014 Jun 19;157(7):1685-97.
3. Armstrong EH, Goswami D, Noy N , Griffin PR and Ortlunld EA (2014) Structural basis for ligand regulation of the Fatty Acid Binding Protein 5, Peroxisome Proliferator-Activated Receptor β/δ (FABP5-PPARβ/δ) signaling pathway. JBC 2014 Apr. 1.
4. Zhang Y, Goswami D, Wang D, Wang TS, Sen S, Magliery TJ, Griffin PR, Wang F and Schultz PG (2014) An Antibody with an Antiparallel Heterodimeric coiled Coil CDR3 Protein Fusion. Angew Chem Int Ed Engl Jan 3;53(1):132-5.
5. Qiang G, Xue S, Yang JJ, Du J, Pang X, Li X, Goswami D, Griffin PR, Ortlund E, Chan BC and Ye K (2013) Identification of a Small Molecular Insulin Receptor Agonist with Potent Antidiabetic Activity. Diabetes 2014 Apr;63(4):1394-409.
6. Marciano DP, Chang MR, Corzo C, Goswami D, Lam V, Pascal BD, and Griffin PR (2013) The therapeutic potential of Nuclear Receptor Modulators for Treatment of Metabolic Disorders: PPARG, REV-ERB, ROR. Cell metabolism 2014 Feb 4;19(2):193-208.
7. Goswami D, Devarakonda S, Chalmers MJ, Pascal B, Spiegelman BM, Griffin PR (2013). Time window expansion for HDX analysis of an intrinsically disordered protein. J Am Soc Mass Spectrom Oct;24(10):1584-92.
8. Landgraf RR*, Goswami D*, Rajamohan F, Harris MS, Pascal BD, Chalmers MJ, Kurumbail R. Griffin PR (2013) Mechanism of activation of AMP activated protein kinase revealed by hydrogen/deuterium exchange mass spectrometry. Structure Nov 5;21(11):1942-53.
9. Harms MJ, Eick GN, Goswami D, Colucci JK, Griffin PR, Ortlund EA,Thornton JW (2013) Biophysical mechanisms for large-effect mutations in the evolution of steroid hormone receptors. Proceedings of national academy of science U S A. Jul 9;110(28):11475-80.
10. Kumar R, Moure CM, Khan SH, Callaway C, Grimm S, Goswami D, Griffin PR, and Edwards DP (2013) Regulation of the structurally dynamic amino-terminal domain of progesterone receptor by protein induced folding. J Biol Chem Oct 18;288(42):30285-99.
11. Pascal BD, Willis S, Lauer JL, Landgraf RR, West GM, Marciano D, Novick S, Goswami D, Chalmers MJ, Griffin PR. (2012). HDX Workbench: Software for the Analysis of H/D Exchange MS Data. J Am Soc Mass Spectrom. Jun 13.
12. Khan SH, Awasthi S, Guo C, Goswami D, Ling J, Griffin PR, Simons SS Jr, Kumar R. (2012) Binding of the N-terminal region of coactivator TIF2 to the intrinsically disordered AF1 domain of the glucocorticoid receptor is accompanied by conformational reorganizations. J Biol Chem. Dec 28;287(53):44546-60.
13. Goswami D, Kaur J, Surade S, Grell E and Michel H. (2012) Heterologous production, functional and thermodynamic characterization of cation diffusion facilitator (CDF) transporters of mesophilic and hyperthermophilic origin. Biol Chem. Jul;393(7):617-29.
14. Adkar BV, Tripathi A, Sahoo A, Bajaj K, Goswami D, Chakrabarti P, Swarnkar MK, Gokhale RS, Varadarajan R. (2012) Protein model discrimination using mutational sensitivity derived from deep sequencing. Structure. Feb 8;20(2):371-81.
15. Bajaj K, Dewan PC, Chakrabarti P, Goswami D, Barua B, Baliga C, Varadarajan R. (2008). Structural correlates of the temperature sensitive phenotype derived from saturation mutagenesis studies of CcdB.Biochemistry 47(49):12964-73.
16. Naik PR, Sahoo N, Goswami D, Ayyadurai N, Sakthivel N. (2008) Genetic and functional diversity among fluorescent pseudomonads isolated from the rhizosphere of banana. Microb Ecol. Oct;56(3):492-504.