Dr. Cai Lu

University of Louisville, USA

Email: [email protected]

Qualifications

1990 Ph.D., Norman Bethune University of Medical Sciences, China

1986 M.Sc., Norman Bethune University of Medical Sciences, China

1983 B.Sc., Norman Bethune University of Medical Sciences, China

Publications (selected)

1. Li, Y., Hui, X., Gu, C., Lin, Q., Abdelbaset-Ismail, A., Xu, Z., Yadav, S., Huang, H. and others. Human FGF1ΔHBS Gene Therapy as Treatment for Metabolic Dysfunction-Associated Steatohepatitis in ApoE-KO Mice. Cells, 15(5), 387, 2026.
2. Nagarajan, D., Vemuri, V., Kratholm, N., Cathey, D., Sharma, P., Cai, L., Huang, J. and others. Withaferin A Attenuates Angiotensin II-Induced Right Ventricular Dysfunction and Fibrosis. International Journal of Molecular Sciences, 27(4), 1877, 2026.
3. Yu, J.J., Han, J.G., Tan, Y., Xu, J.X., LeBlanc, A., Keller, B.B., Huang, J. and Cai, L. Right ventricular dysfunctions in type 1 diabetic mice: A longitudinal study. World Journal of Diabetes, 16(10), 109526, 2025.
4. Islam, R., Yang, J., Li, M., Mokshagundam, S.P., Cai, L. and Li, J. Fatty acids and physical activity are critical for β-cell mass and insulin sensitivity: Pathways to T2D and prevention. Journal of Theoretical Biology, 611, 112188, 2025.
5. Hui, X., Gu, C., Abdelbaset-Ismail, A., Xu, J., Tse, W., Raj, A., Zhu, W., Deng, Z. and others. Abstract Fri012: Dual CXCR4/CXCR7 Modulation: TC14012 as a Novel Therapeutic Strategy Against Doxorubicin-Induced Cardiotoxicity. Circulation Research, 137(Suppl_1), 2025.
6. Lin, Q., Hui, X., Gu, C., Min, K., Xiong, L., Zhou, W., Xu, J., Watson, S.E. and others. High-Fat Diet Differentially Regulates Fibroblast Growth Factor Expression in Metabolic Tissues of Young and Aged Male Mice. Journal of the Endocrine Society, 9(8), bvaf096, 2025.
7. Hui, X., Lin, Q., Liu, K., Gu, C., Abdelbaset-Ismail, A., Wintergerst, K.A., Deng, Z. and others. Fibroblast growth factor 16: Molecular mechanisms, signalling crosstalk, and emerging roles in cardiac biology and metabolic regulation. Pharmacological Research, 107858, 2025.
8. Vielee, S.T., Buchanan, W.J., Roof, S.H., Kahloon, R., Evans, E., Isibor, J., Patel, M. and others. Chromium selectively accumulates in the rat hippocampus after 90 days of exposure to Cr (VI) in drinking water and induces age-and sex-dependent metal dyshomeostasis. Toxics, 12(10), 722, 2024.
9. Saedi, S., Tan, Y., Watson, S.E., Wintergerst, K.A. and Cai, L. Potential pathogenic roles of ferroptosis and cuproptosis in cadmium-induced or exacerbated cardiovascular complications in individuals with diabetes. Frontiers in Endocrinology, 15, 1461171, 2024.
10. Sears, L.L., Smith, M.J., Cai, L. and Zierold, K.M. Association of manganese overexposure and neurobehavioral function is moderated by arsenic: A mixture analysis of children exposed to coal ash. ISEE Conference Abstracts, 2024(1), 2024.
11. Cai, L., Tan, Y., Islam, M.S., Horowitz, M. and Wintergerst, K.A. Diabetic cardiomyopathy: Importance of direct evidence to support the roles of NOD-like receptor protein 3 inflammasome and pyroptosis. World Journal of Diabetes, 15(8):1659, 2024.
12. Hui, X., Gu, C., Abdelbaset-Ismail, A., Xu, J., Tse, W., Raj, A., Deng, Z., Zhu, W. and others. Dual Targeting CXCR4 and CXCR7 Prevents Doxorubicin-Induced Cardiotoxicity by Eliminating Cardiac Inflammation and Preserving Cardiomyocyte Function. Circulation Research, 135, 2024.
13. Cai, L., Horowitz, M. and Islam, M.S. Potential therapeutic targets for the prevention of diabetic nephropathy: Glycyrrhetinic acid. World Journal of Diabetes, 14(12):1717, 2023.
14. Cai, L., Tan, Y., Watson, S. and Wintergerst, K. Diabetic cardiomyopathy–zinc preventive and therapeutic potentials by its anti-oxidative stress and sensitizing insulin signaling pathways. Toxicology and Applied Pharmacology, 477, 116694, 2023.
15. Wang, K., Sun, S., Zhang, G., Lu, Z., Chen, H., Fan, X., Gu, C., Pan, X., Lin, Q. and others. CXCR7 agonist TC14012 improves angiogenic function of endothelial progenitor cells via activating Akt/eNOS pathway and promotes ischemic angiogenesis in diabetic limb ischemia. Cardiovascular Drugs and Therapy, 37(5):849-863, 2023.
16. Cai, L., Holm, R.H., Biddle, D.J., Zhang, C.H., Talley, D., Smith, T. and States, J.C. Wastewater-based epidemiology for comprehensive communitywide exposome surveillance: A gradient of metals exposure. medRxiv, 2023.
17. Hopkins, C.D., Wessel, C., Chen, O., El-Kersh, K., Cave, M.C., Cai, L. and Huang, J. Potential roles of metals in the pathogenesis of pulmonary and systemic hypertension. International Journal of Biological Sciences, 19(16):5036, 2023.
18. Lin, Q., Chen, O., Wise Jr, J.P., Shi, H.X., Wintergerst, K.A., Cai, L. and Tan, Y. FGF1ΔHBS delays the progression of diabetic nephropathy in late-stage type 2 diabetes mouse model by alleviating renal inflammation, fibrosis, and apoptosis. Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease, 1868(8), 166414, 2022.
19. Ye, F., Sun, C., Xie, Y., Wang, B. and Cai, L. Medical Application and Radiobiology Research of Particle Radiation. Frontiers in Public Health, 10, 955116, 2022.
20. Cai, L., Mohanraj, R., Young, J.L. and Xin, Y. Cardiovascular Diseases Related to Diabetes and Obesity. Frontiers Media SA, 2022.
21. Zhang, G., Kang, Y., Cathey, D., LeBlanc, A.J., Cai, J., Cai, L., Wang, S. and Huang, J. Sulforaphane does not protect right ventricular systolic and diastolic functions in Nrf2 knockout pulmonary artery hypertension mice. Cardiovascular Drugs and Therapy, 36(3):425-436, 2022.
22. Rajesh, M., Xin, Y., Young, J.L. and Cai, L. Cardiovascular diseases related to diabetes and obesity. Frontiers in Endocrinology, 13, 916142, 2022.

Personal Details

https://orcid.org/0000-0003-3048-1135

https://profiles.louisville.edu/lu.cai

https://scholar.google.com/citations?user=KpG-4QIAAAAJ&hl=en

https://www.researchgate.net/profile/Lu-Cai-2