Dr. Pallav Patel

Department of Molecular Pharmacology and Chemistry

Memorial Sloan Kettering Cancer Center, USA

Email: [email protected]

Qualifications

Ph.D., Pharmaceutical Sciences, St. John’s University & Memorial Sloan-Kettering Cancer Center (MSKCC)

M.Sc., Pharmaceutical Sciences, St. John’s University

B.Sc., Pharmacy, K.B. Institute of Pharmaceutical Education and Research (KBIPER)

Publications (selected)

1. Boländer, Alexander & Zatorska, Danuta & He, Huazhong & Joshi, Suhasini & Sharma, Sahil & Digwal, Chander & Patel, Hardik & Sun, Weilin & Imber, Brandon & Ochiana, Stefan & Patel, Maulik & Shrestha, Liza & Shah, Smit & Wang, Shuo & Karimov, Rashad & Tao, Hui & Patel, Pallav & Martin, Ananda & Yan, Pengrong & Chiosis, Gabriela. (2021). Chemical tools for epichaperome-mediated interactome dysfunctions of the central nervous system. Nature Communications. 12. 10.1038/s41467-021-24821-2. 
2. Rodina, Anna & Taldone, Tony & Kang, Yanlong & Patel, Pallav & Koren, John & Yan, Pengrong & Gomes, Erica & Yang, Chenghua & Patel, Maulik & Shrestha, Liza & Ochiana, Stefan & Maharaj, Ronnie & Gozman, Alexander & Cox, Marc & Erdjument-Bromage, Hediye & Hendrickson, Ronald & Cerchietti, Leandro & Melnick, Ari & Guzman, Monica & Chiosis, Gabriela. (2015). Development of chemical tools to study the endogenous Hsp70 interactome in malignant cells. Cancer Research. 75. 1733-1733. 10.1158/1538-7445.AM2015-1733. 
3. Yan, Pengrong & Patel, Hardik & Patel, Pallav & Ochiana, Stefan & Sun, Weilin & Shah, Smit & Finotti, Paola & Leifer, Cynthia & Li, Zihai & Gewirth, Daniel & Taldone, Tony & Chiosis, Gabriela. (2015). Tumor-specific regulation of receptor tyrosine kinases by Grp94. Cancer Research. 75. 4716-4716. 10.1158/1538-7445.AM2015-4716. 
4. Ochiana, Stefan & Taldone, Tony & Patel, Hardik & Patel, Pallav & Yan, Pengrong & Sun, Weilin & Rodina, Anna & Shah, Smit & Gewirth, Daniel & Chiosis, Gabriela. (2015). Development of selective GRP94 inhibitors for the treatment of cancer. Cancer Research. 75. 2831-2831. 10.1158/1538-7445.AM2015-2831. 
5. Patel, Hardik & Patel, Pallav & Ochiana, Stefan & Yan, Pengrong & Sun, Weilin & Patel, Maulik & Shah, Smit & Tramentozzi, Elisa & Brooks, James & Boländer, Alexander & Shrestha, Liza & Stephani, Ralph & Finotti, Paola & Leifer, Cynthia & Li, Zihai & Gewirth, Daniel & Taldone, Tony & Chiosis, Gabriela. (2015). Structure–Activity Relationship in a Purine-Scaffold Compound Series with Selectivity for the Endoplasmic Reticulum Hsp90 Paralog Grp94. Journal of medicinal chemistry. 58. 10.1021/acs.jmedchem.5b00197. 
6. Taldone, Tony & Ochiana, Stefan & Patel, Pallav & Chiosis, Gabriela. (2014). Selective targeting of the stress chaperome as a therapeutic strategy. Trends in pharmacological sciences. 35. 10.1016/j.tips.2014.09.001. 
7. Rodina, Anna & Taldone, Tony & Kang, Yanlong & Patel, Pallav & Koren, John & Yan, Pengrong & Gomes, Erica & Yang, Chenghua & Patel, Maulik & Shrestha, Liza & Ochiana, Stefan & Santarossa, Cristina & Maharaj, Ronnie & Gozman, Alexander & Cox, Marc & Erdjument-Bromage, Hediye & Hendrickson, Ronald & Cerchietti, Leandro & Melnick, Ari & Chiosis, Gabriela. (2014). Affinity Purification Probes of Potential Use To Investigate the Endogenous Hsp70 Interactome in Cancer. ACS chemical biology. 9. 10.1021/cb500256u. 
8. Taldone, Tony & Kang, Yanlong & Patel, Hardik & Patel, Maulik & Patel, Pallav & Rodina, Anna & Patel, Yogita & Gozman, Alexander & Maharaj, Ronnie & Clement, Cristina & Lu, Alvin & Young, Jason & Chiosis, Gabriela. (2014). Heat Shock Protein 70 Inhibitors. 2. 2,5′-Thiodipyrimidines, 5-(Phenylthio)pyrimidines, 2-(Pyridin-3-ylthio)pyrimidines, and 3-(Phenylthio)pyridines as Reversible Binders to an Allosteric Site on Heat Shock Protein 70. Journal of medicinal chemistry. 57. 10.1021/jm401552y. 
9. Kang, Yanlong & Taldone, Tony & Patel, Hardik & Patel, Pallav & Rodina, Anna & Gozman, Alexander & Maharaj, Ronnie & Clement, Cristina & Patel, Maulik & Brodsky, Jeffrey & Young, Jason & Chiosis, Gabriela. (2014). Heat Shock Protein 70 Inhibitors. 1. 2,5′-Thiodipyrimidine and 5-(Phenylthio)pyrimidine Acrylamides as Irreversible Binders to an Allosteric Site on Heat Shock Protein 70. Journal of medicinal chemistry. 57. 10.1021/jm401551n. 
10. Rodina, Anna & Patel, Pallav & Kang, Yanlong & Patel, Yogita & Baaklini, Imad & Wong, Michael & Taldone, Tony & Yan, Pengrong & Yang, Chenghua & Maharaj, Ronnie & Gozman, Alexander & Patel, Maulik & Patel, Hardik & Chirico, William & Erdjument-Bromage, Hediye & Talele, Tanaji & Young, Jason & Chiosis, Gabriela. (2013). Identification of an Allosteric Pocket on Human Hsp70 Reveals a Mode of Inhibition of This Therapeutically Important Protein. Chemistry & biology. 20. 10.1016/j.chembiol.2013.10.008. 
11. Patel, Pallav & Yan, Pengrong & Seidler, Paul & Patel, Hardik & Sun, Weilin & Yang, Chenghua & Que, Nanette & Taldone, Tony & Finotti, Paola & Stephani, Ralph & Gewirth, Daniel & Chiosis, Gabriela. (2013). Paralog-selective Hsp90 inhibitors define tumor-specific regulation of HER2. Nature chemical biology. 9. 10.1038/nchembio.1335. 
12. Taldone, Tony & Patel, Pallav & Patel, Maulik & Patel, Hardik & Evans, Christopher & Rodina, Anna & Ochiana, Stefan & Shah, Smit & Uddin, Mohammad & Gewirth, Daniel & Chiosis, Gabriela. (2013). Experimental and Structural Testing Module to Analyze Paralogue-Specificity and Affinity in the Hsp90 Inhibitors Series. Journal of medicinal chemistry. 56. 10.1021/jm400619b. 
13. Taldone, Tony & Patel, Pallav & Kang, Yanlong & Rodina, Anna & Talele, Tanaji & Chiosis, Gabriela. (2012). Rational design of small molecule inhibitors that bind to an allosteric pocket on human heat shock protein 70 (Hsp70). Cancer Research. 72. 3895-3895. 10.1158/1538-7445.AM2012-3895. 
14. Taldone, Tony & Patel, Pallav & Patel, Hardik & Chiosis, Gabriela. (2012). Reaction of Aryl Fluorides with Sodium Sulfide: Investigation into the Selectivity of Substitution of Fluorobenzonitriles to Yield Mercaptobenzonitriles via S N Ar Displacement of Fluorine.. Tetrahedron Letters. 53. 2548–2551. 10.1016/j.tetlet.2012.03.032. 
15. Sun, Weilin & Patel, Pallav & Stephani, Ralph & Chiosis, Gabriela. (2012). An Efficient Copper-Catalyzed Microwave-Assisted S-Arylation Towards the Synthesis of 8-Arylsulfanyl Adenines.. ChemInform. 43. 10.1002/chin.201217176. 
16. Rodina, Anna & Kang, Yanlong & Taldone, Tony & Patel, Pallav & Patel, Hardik & Chiosis, Gabriela. (2012). The Apoptosis Related BIM Is An HSP70‐Specific Client Protein. The FASEB Journal. 26. 10.1096/fasebj.26.1_supplement.955.6. 
17. Rodina, Anna & Kang, Yanlong & Taldone, Tony & Patel, Hardik & Patel, Pallav & Caldas-Lopes, Eloisi & Erdjument-Bromage, Hediye & Guzman, Monica & Young, Jason & Melnick, Ari & Chiosis, Gabriela. (2011). YK5, a small molecule inhibitor of Hsp70 and Hsc70, reveals a multifaceted role for the Hsp70 chaperones in regulating oncogenic and non-oncogenic addiction of tumors. Cancer Research. 71. 2579-2579. 10.1158/1538-7445.AM2011-2579. 
18. Taldone, Tony & Zatorska, Danuta & Patel, Pallav & Zong, Hongliang & Rodina, Anna & Ahn, James & Moulick, Kamalika & Guzman, Monica & Chiosis, Gabriela. (2011). Design, Synthesis and Evaluation of Small Molecule Hsp90 Probes. Bioorganic & medicinal chemistry. 19. 2603-14. 10.1016/j.bmc.2011.03.013. 
19. Bhatt, Aaditya & Patel, Pallav & Patel, Maulik & Singh, Satyakam & Lau-Cam, Cesar & Talele, Tanaji. (2011). CoMSIA study on substituted aryl alkanoic acid analogs as GPR40 agonists. Chemical biology & drug design. 77. 361-72. 10.1111/j.1747-0285.2011.01112.x. 
20. Taldone, Tony & Gillan, Victoria & Sun, Weilin & Rodina, Anna & Patel, Pallav & Maitland, Kirsty & O'Neill, Kerry & Chiosis, Gabriela & Devaney, Eileen. (2010). Assay Strategies for the Discovery and Validation of Therapeutics Targeting Brugia pahangi Hsp90. PLoS neglected tropical diseases. 4. e714. 10.1371/journal.pntd.0000714. 

Profile Details

https://synapse.mskcc.org/synapse/people/14701-Pallav_Patel