Prof. Qiang Wu

Shanghai Center for Systems Biomedicine

Shanghai Jiao Tong University, China

Distinguished Professor

Email: [email protected]

Qualifications

1994 - 1998  Ph.D., Molecular and Cellular Biology State University of New York (SUNY), Stony Brook and Cold Spring Harbor Laboratory, USA

1990 - 1993  M.Sc., Virology Research Unit, School of Life Sciences, Fudan University, China

1986 - 1990  B.Sc., Department of Microbiology, School of Life Sciences, Fudan University, China

Publications (Selected)

1. Zhang, Y., & Wu, Q. (2025). CCCTC-binding factor N-terminal domain regulates clustered protocadherin gene expression by enhancing cohesin processivity. Journal of Biological Chemistry, 301(4).
2. Liu, L., Tang, Y., Zhang, Y., & Wu, Q. (2024). A negatively charged region within carboxy-terminal domain maintains proper CTCF DNA binding. iScience, 27(12).
3. Huang, H., & Wu, Q. (2024). Pushing the TAD boundary: Decoding insulator codes of clustered CTCF sites in 3D genomes. BioEssays, 46(10), 2400121.
4. Zhang, M., Huang, H., Li, J., & Wu, Q. (2024). ZNF143 deletion alters enhancer/promoter looping and CTCF/cohesin geometry. Cell Reports, 43(1).
5. Ge, X., Huang, H., Han, K., Xu, W., Wang, Z., & Wu, Q. (2023). Outward-oriented sites within clustered CTCF boundaries are key for intra-TAD chromatin interactions and gene regulation. Nature Communications, 14(1), 8101.
6. Dong, H., Li, J., Wu, Q., & Jin, Y. (2023). Confluence and convergence of Dscam and Pcdh cell-recognition codes. Trends in Biochemical Sciences, 48(12), 1044-1057.
7. Liu, Y., Li, J., & Wu, Q. (2023). Short tandem repeats of human genome are intrinsically unstable in cultured cells in vivo. Gene, 877, 147539.
8. Lv, X., Li, S., Li, J., Yu, X. Y., Ge, X., Li, B., ... & Shi, S. H. (2022). Patterned cPCDH expression regulates the fine organization of the neocortex. Nature, 612(7940), 503-511.
9. Liu, Y., Wang, K., Huang, L., Zhao, J., Chen, X., Wu, Q., ... & Li, G. (2022). Ser68 phosphoregulation is essential for CENP-A deposition, centromere function and viability in mice. Science China Life Sciences, 65(9), 1881-1889.
10. Wang, K., Liu, Y., Yu, Z., Gu, B., Hu, J., Huang, L., ... & Li, G. (2021). Phosphorylation at Ser68 facilitates DCAF11-mediated ubiquitination and degradation of CENP-A during the cell cycle. Cell Reports, 37(6).
11. Zhou, Y., Xu, S., Zhang, M., & Wu, Q. (2021). Systematic functional characterization of antisense eRNA of protocadherin α composite enhancer. Genes & Development, 35(19-20), 1383-1394.
12. He, X. L., Li, J. H., & Wu, Q. (2021). Combinatorial CRISPR inversions of CTCF sites in HOXD cluster reveal complex insulator function. Yi Chuan= Hereditas, 43(8), 758-774.
13. Wang, L., Li, J. H., Huang, H. Y., & Wu, Q. (2021). Serial deletions of tandem reverse CTCF sites reveal balanced HOXD regulatory landscape of enhancers. Yi Chuan= Hereditas, 43(8), 775-791.
14. Tang, Y., Jia, Z., Xu, H., Da, L. T., & Wu, Q. (2021). Mechanism of REST/NRSF regulation of clustered protocadherin α genes. Nucleic acids research, 49(8), 4506-4521.
15. Jia, Z., & Wu, Q. (2020). Clustered protocadherins emerge as novel susceptibility loci for mental disorders. Frontiers in neuroscience, 14, 587819.
16. Wu, Q., & Shou, J. (2020). Toward precise CRISPR DNA fragment editing and predictable 3D genome engineering. Journal of Molecular Cell Biology, 12(11), 828-856.
17. Wu, Q., Liu, P., & Wang, L. (2020). Many facades of CTCF unified by its coding for three-dimensional genome architecture. Journal of Genetics and Genomics, 47(8), 407-424.
18. Wu, Y., Jia, Z., Ge, X., & Wu, Q. (2020). Three-dimensional genome architectural CCCTC-binding factor makes choice in duplicated enhancers at Pcdhα locus. Science China Life Sciences, 63(6), 835-844.

Profile Details

WoS ResearcherID: MIQ-4261-2025

https://orcid.org/0000-0003-3841-3591

https://scsb.sjtu.edu.cn/en/Professor/12334.html

https://scholar.google.com/citations?user=1GWJwo8AAAAJ&hl=en

https://www.researchgate.net/profile/Qiang-Wu-12