Dr. Dharani Kumar Ajithdoss

Texas A&M University, USA

Email: [email protected]

Qualifications

2009 Ph.D., Texas A&M University (TAMU) College Station, USA

2002 M.Sc., A.N.G.Ranga Agriculture University, India

2000 B.Sc., Tamil Nadu Veterinary & Animal Sciences University, India

Publications (selected)

1. Decker, C. E., Idun, J., Mohrs, K., et al. (2026). Optimally engineered HLA/peptide-specific CAR-T cells outperform TCR-T cells to eradicate solid tumors. Science Diseases, 12(4), eadx9371.
2. Ajithdoss, D. K., Liao, Y. F., Reddy, S. M., et al. (2025). Marek's Disease Virus (MDV) Meq Oncoprotein Plays Distinct Roles in Tumor Incidence, Distribution, and Size. Viruses-Basel, 17(2), 259.
3. Patel, AK., Trageser, K., Kim, H., et al. (2024). Peripheral human red blood cell development in human immune system mouse model with heme oxygenase-1 deficiency. Blood Advances, 8(23), 5975–5987.
4. Srivatsan, S., Buonagurio, B., Nagashima, K., et al. (2023). IL-4 and IL-13 drive distinct and overlapping disease-associated signatures in cell types relevant to atopic dermatitis. Journal of Investigative Dermatology, 143(11), S367.
5. Decker, C. E., Idun, J., Mohrs, K., et al. (2023). TCR-T and CAR-T cells targeting HLA-A2/MAGEA4 demonstrate differential tumor control, reflecting co-stimulatory signaling requirements. Cancer Research, 83(7), 1780.
6. Le Floc'h, A., Nagashima, K., Birchard, D., et al. (2023). Blocking common γ chain cytokine signaling ameliorates T cell-mediated pathogenesis in disease models. Science Translational Medicine, 15(678), eabo0205.
7. Scott, G., Asrat, S., Allinne, J., et al. (2023). IL-4 and IL-13, not eosinophils, drive type 2 airway inflammation, remodeling and lung function decline. Cytokine, 162, 156091.
8. Le Floch-Ramondou, A., Nagashima, K., Farrales, P., et al. (2022). Blockade of Common Gamma Chain Cytokine Signaling with REGN7257, an Interleukin 2 Receptor Gamma (IL2RG) Monoclonal Antibody, Protected Mice from Inflammatory and Autoimmune Diseases. Blood, 140(Suppl 1), 195.
9. McAleavy, M., Zhang, Q., Ehmann, P. J., et al. (2022). The Activin/FLRG Pathway Associates with Poor COVID-19 Outcomes in Hospitalized Patients. Molecular and Cellular Biology, 42(1), e00467-21.
10. Scott, G., Allinne, J., Asrat, S., et al. (2021). Comparison of transcriptional differences between IL-4Rα and IL-5 blockade in a mouse model of asthma. European Respiratory Journal, 58(Suppl 65), PA674.
11. Singh, D. K., Singh, B., Ganatra, R. S., et al. (2021). Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets (vol 6, pg 73, 2021). Nature Microbiology, 6(3), 413.
12. Singh, D. K., Singh, B., Ganatra, R. S., et al. (2021). Responses to acute infection with SARS-CoV-2 in the lungs of rhesus macaques, baboons and marmosets. Nature Microbiology, 6(1), 73.
13. Hovhannisyan, Z., Liu, N. Y., Khalil-Aguero, S., et al. (2020). Enhanced IL-36R signaling promotes barrier impairment and inflammation in skin and intestine. Science Immunology, 5(54), eaax1686.
14. Baum, A., Ajithdoss, D., Copin, R., et al. (2020). REGN-COV2 antibodies prevent and treat SARS-CoV-2 infection in rhesus macaques and hamsters. Science, 370(6520), 1110.
15. Waite, J. C., Wang, B., Haber, L., et al. (2020). Tumor-targeted CD28 bispecific antibodies enhance the antitumor efficacy of PD-1 immunotherapy. Science Translational Medicine, 12(549), eaba2325.
16. Skokos, D., Waite, J. C., Haber, L., et al. (2020). A class of costimulatory CD28-bispecific antibodies that enhance the antitumor activity of CD3-bispecific antibodies. Science Translational Medicine, 12(525), eaaw7888.
17. Chung, C. J., Cha, S. H., Grimm, A. L., et al. (2018). Pigs that recover from porcine reproduction and respiratory syndrome virus infection develop cytotoxic CD4+CD8+ and CD4+CD8- T-cells that kill virus infected cells. PLoS ONE, 13(9), e0203482.
18. Ajithdoss, D. K., Torchetti, M. K., Badcoe, L., et al. (2017). Pathologic Findings and Viral Antigen Distribution During Natural Infection of Ring-Necked Pheasants With H5N2 Highly Pathogenic Avian Influenza Virus A. Veterinary Pathology, 54(2), 312–315.
19. Vitt, J. P., Saunders, A. B., O'Brien, M. T., et al. (2016). Diagnostic Features of Acute Chagas Myocarditis with Sudden Death in a Family of Boxer Dogs. Journal of Veterinary Internal Medicine, 30(4), 1210–1215.
20. Small, C. M., Ajithdoss, D. K., Hoffmann, A. R., et al. (2014). Immunization with a Borrelia burgdorferi BB0172-Derived Peptide Protects Mice against Lyme Disease. PLoS ONE, 9(2), e88245.

Profile Details
https://scholar.google.com/citations?hl=en&user=YSacqrcAAAAJ&view_op=list_works&sortby=pubdate
https://www.researchgate.net/scientific-contributions/Dharani-Ajithdoss-2168985343


WOS ResearcherID: DUM-2435-2022