Hee-Jeong Im Sampen

Departments of Biochemistry

Rush University Medical Center

Chicago, USA

Associate Professor

Email: [email protected]

Qualifications

1992-1996 Ph.D., University of New South Wales, Biotechnolgy

1990-1991 M.S., University of New South Wales, Microbiology

Publications (Selected)

1. Shih, S. Y., Grant, M. P., Epure, L. M., Alad, M., Lerouge, S., Huk, O. L., Im Sampen, H. J.... & Mwale, F. (2024). Advances in the regulation of periostin for osteoarthritic cartilage repair applications. Biomolecules, 14(11), 1469.
2. Alad, M., Grant, M. P., Epure, L. M., Shih, S. Y., Merle, G., Im, H. J., ... & Mwale, F. (2024). Short link N modulates inflammasome activity in intervertebral discs through interaction with CD14. Biomolecules, 14(10), 1312.
3. Huang, C., van Wijnen, A. J., & Im, H. J. (2024). Serotonin transporter (5-hydroxytryptamine transporter, SERT, SLC6A4) and sodium-dependent reuptake inhibitors as modulators of pain behaviors and analgesic responses. The Journal of Pain, 25(3), 618-631.
4. Ma, K., Pham, T., Wang, J., O-Sullivan, I., DiCamillo, A., Du, S., ... & Im, H. J. (2024). Nanoparticle-based inhibition of vascular endothelial growth factor receptors alleviates osteoarthritis pain and cartilage damage. Science Advances, 10(7), eadi5501.
5. Singh, G., InSug, O., Anbazhagan, A. N., Ranjan, K. C., Farooqui, Z., Ma, K., ... & Im, H. J. (2024). Loss of PKCδ/Prkcd prevents cartilage degeneration in joints but exacerbates hyperalgesia in an experimental osteoarthritis mouse model. Gene, 893, 147920.
6. Yan, D., Chen, D., Cool, S. M., van Wijnen, A. J., Mikecz, K., Murphy, G., & Im, H. J. (2024). Retraction Note: Fibroblast growth factor receptor 1 is principally responsible for fibroblast growth factor 2-induced catabolic activities in human articular chondrocytes.
7. Huang, C., van Wijnen, A. J., & Im Sampen, H. J. (2023). Serotonin transporter (5-HTT, SERT, SLC6A4) and sodium-dependent reuptake inhibitors (SRIs) as modulators of pain behaviors and analgesic responses. The journal of pain, 25(3), 618.
8. Dara, P., Farooqui, Z., Mwale, F., Choe, C., van Wijnen, A. J., & Im, H. J. (2023). Opiate antagonists for chronic pain: a review on the benefits of low-dose Naltrexone in arthritis versus non-arthritic diseases. Biomedicines, 11(6), 1620.
9. Ma, K., Singh, G., Wang, J., O-Sullivan, I., Votta-Velis, G., Bruce, B., ... & Im, H. J. (2023). Targeting vascular endothelial growth factor receptors as a therapeutic strategy for osteoarthritis and associated pain. International Journal of Biological Sciences, 19(2), 675.
10. Yun, H., Im, H. J., Choe, C., & Roh, S. (2022). Effect of LOXL2 on metastasis through remodeling of the cell surface matrix in non-small cell lung cancer cells. Gene, 830, 146504.
11. O-Sullivan, I., Natarajan Anbazhagan, A., Singh, G., Ma, K., Green, S. J., Singhal, M., ... & Im, H. J. (2022). Lactobacillus acidophilus mitigates osteoarthritis-associated pain, cartilage disintegration and gut microbiota dysbiosis in an experimental murine OA model. Biomedicines, 10(6), 1298.
12. Arora, V., Singh, G., InSug, O., Ma, K., Anbazhagan, A. N., Votta-Velis, E. G., ... & Im, H. J. (2021). Gut-microbiota modulation: the impact of the gut-microbiota on osteoarthritis. Gene, 785, 145619.
13. Qiu, S., Shi, C., Anbazhagan, A. N., Das, V., Arora, V., Kc, R., ... & Im, H. J. (2020). Absence of VEGFR‐1/Flt‐1 signaling pathway in mice results in insensitivity to discogenic low back pain in an established disc injury mouse model. Journal of cellular physiology, 235(6), 5305-5317.
14. Alaqeel, M., Grant, M. P., Epure, L. M., Salem, O., AlShaer, A., Huk, O. L., Im Sampen, H. J.... & Mwale, F. (2020). Link N suppresses interleukin-1β-induced biological effects on human osteoarthritic cartilage. Eur. Cell Mater, 39, 65-76.
15. Shi, C., Wu, L., Lin, W., Cai, Y., Zhang, Y., Hu, B., Im Sampen, H. J.... & van Wijnen, A. J. (2019). MiR-202-3p regulates interleukin-1β-induced expression of matrix metalloproteinase 1 in human nucleus pulposus. Gene, 687, 156-165.
16. Bajaj, J. S., Sharma, A., Dudeja, P. K., Iqbal, Z., Singh, A. B., Wilson, K. T., Im Sampen, H. J.... & Gillevet, P. M. (2019). Targeting gut microbiome interactions in service-related gastrointestinal and liver diseases of veterans. Gastroenterology, 157(5), 1180-1183.
17. Camilleri, E. T., Dudakovic, A., Riester, S. M., Galeano-Garces, C., Paradise, C. R., Bradley, E. W., Im Sampen, H. J.... & Van Wijnen, A. J. (2018). Loss of histone methyltransferase Ezh2 stimulates an osteogenic transcriptional program in chondrocytes but does not affect cartilage development. Journal of biological chemistry, 293(49), 19001-19011.
18. Shi, C., Wu, H., Du, D., Im, H. J., Zhang, Y., Hu, B., ... & Yuan, W. (2018). Nicotinamide phosphoribosyltransferase inhibitor APO866 prevents IL-1β-induced human nucleus pulposus cell degeneration via autophagy. Cellular Physiology and Biochemistry, 49(6), 2463-2482.
19. Lu, J., Ji, M. L., Zhang, X. J., Shi, P. L., Wu, H., Wang, C., & Im, H. J. (2017). MicroRNA-218-5p as a potential target for the treatment of human osteoarthritis. Molecular Therapy, 25(12), 2676-2688.
20. Nagao, M., Hamilton, J. L., Kc, R., Berendsen, A. D., Duan, X., Cheong, C. W., Im Sampen, H. J.... & Olsen, B. R. (2017). Vascular endothelial growth factor in cartilage development and osteoarthritis. Scientific reports, 7(1), 13027.
21. Riester, S. M., Denbeigh, J. M., Lin, Y., Jones, D. L., De Mooij, T., Lewallen, E. A., Im Sampen, H. J.... & Van Wijnen, A. J. (2017). Safety studies for use of adipose tissue-derived mesenchymal stromal/stem cells in a rabbit model for osteoarthritis to support a phase I clinical trial. Stem cells translational medicine, 6(3), 910-922.

Profile Details

https://www.sciencedirect.com/author/7102695588/hee-jeongim-im

https://scholar.google.com/citations?user=YUqEm80AAAAJ&hl=en

WoS Researcher ID: A-2968-2008