Department of Chemistry and Biochemistry

University of Notre Dame, USA

Research Scientist

1. Qian, Yuanyuan & Birhanu, Biruk & Yang, Jingdong & Ding, Derong & Janardhanan, Jeshina & Mobashery, Shahriar & Chang, Mayland. (2023). A Potent and Narrow-Spectrum Antibacterial against Clostridioides difficile Infection. Journal of Medicinal Chemistry. 66. 10.1021/acs.jmedchem.3c01249.
2. Janardhanan, Jeshina & Kim, Choon & Qian, Yuanyuan & Yang, Jingdong & Meisel, Jayda & Ding, Derong & Speri, Enrico & Schroeder, Valerie & Wolter, William & Oliver, Allen & Mobashery, Shahriar & Chang, Mayland. (2023). A dual-action antibiotic that kills Clostridioides difficile vegetative cells and inhibits spore germination. Proceedings of the National Academy of Sciences of the United States of America. 120. e2304110120. 10.1073/pnas.2304110120.
3. Boudreau, Marc & Ding, Derong & Meisel, Jayda & Janardhanan, Jeshina & Spink, Edward & Peng, Zhihong & Qian, Yuanyuan & Yamaguchi, Takao & Testero, Sebastián & O'Daniel, Peter & Leemans, Erika & Lastochkin, Elena & Song, Wei & Schroeder, Valerie & Wolter, William & Suckow, Mark & Mobashery, Shahriar & Chang, Mayland. (2019). Structure-Activity Relationship for the Oxadiazole Class of Antibacterials. ACS Medicinal Chemistry Letters. 2019. 10.1021/acsmedchemlett.9b00379.
4. Janardhanan, Jeshina & Bouley, Renee & Martínez Caballero, Siseth & Peng, Zhihong & Batuecas-Mordillo, Mayte & Meisel, Jayda & Ding, Derong & Schroeder, Valerie & Wolter, William & Mahasenan, Kiran & Hermoso, Juan & Mobashery, Shahriar & Chang, Mayland. (2019). The Quinazolinone Allosteric Inhibitor of PBP 2a Synergizes with Piperacillin and Tazobactam against Methicillin-Resistant Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 63. 10.1128/AAC.02637-18.
5. Nguyen, Trung & Ding, Derong & Wolter, William & Pérez, Rocío & Champion, Matthew & Mahasenan, Kiran & Hesek, Dusan & Lee, Mijoon & Schroeder, Valerie & Jones, Jeffrey & Lastochkin, Elena & Rose, Margaret & Peterson, Charles & Suckow, Mark & Mobashery, Shahriar & Chang, Mayland. (2018). Validation of Matrix Metalloproteinase-9 (MMP-9) as a Novel Target for Treatment of Diabetic Foot Ulcers in Humans and Discovery of a Potent and Selective Small-Molecule MMP-9 Inhibitor That Accelerates Healing. Journal of Medicinal Chemistry. 61. 10.1021/acs.jmedchem.8b01005.
6. Ceballos, Sara & Kim, Choon & Ding, Derong & Mobashery, Shahriar & Chang, Mayland & Torres, Carmen. (2018). Activities of Oxadiazole Antibacterials against Staphylococcus aureus and Other Gram-Positive Bacteria. Antimicrobial Agents and Chemotherapy. 62. AAC.00453-18. 10.1128/AAC.00453-18.
7. Nguyen, Trung & Ding, Derong & Wolter, William & Champion, Matthew & Hesek, Dusan & Lee, Mijoon & Pérez, Rocío & Schroeder, Valerie & Suckow, Mark & Mobashery, Shahriar & Chang, Mayland. (2018). Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers. European journal of pharmacology. 834. 10.1016/j.ejphar.2018.07.014.
8. Mahasenan, Kiran & Ding, Derong & Gao, Ming & Nguyen, Trung & Suckow, Mark & Schroeder, Valerie & Wolter, William & Chang, Mayland & Mobashery, Shahriar. (2018). In Search of Selectivity in Inhibition of ADAM10. ACS Medicinal Chemistry Letters. 9. 10.1021/acsmedchemlett.8b00163.
9. Mahasenan, Kiran & Bastian, Maria & Gao, Ming & Frost, Emma & Ding, Derong & Zorina-Lichtenwalter, Katerina & Jacobs, John & Suckow, Mark & Schroeder, Valerie & Wolter, William & Chang, Mayland & Mobashery, Shahriar. (2017). Exploitation of Conformational Dynamics in Imparting Selective Inhibition for Related Matrix Metalloproteinases. ACS Medicinal Chemistry Letters. 8. 10.1021/acsmedchemlett.7b00130.
10. Erika Leemans, Kiran V. Mahasenan, Malika Kumarasiri, Edward Spink , Derong Ding, Peter I. O’Daniel, Marc A. Boudreau , Elena Lastochkin , Sebastian A. Testero, Takao Yamaguchi , Mijoon Lee, Dusan Hesek , Jed Fisher, Mayland Chang*, Shahriar Mobashery*. Three-dimensional QSAR analysis and design of new 1, 2, 4-oxadiazole antibecterials. Bioorg. Med. Chem. Lett. 2016, 26, 1011-1015
11. Derong Ding, Marc A. Boudreau, Erika Leemans, Edward Spink, Takao Yamaguchi, Sebastian A. Testero, Peter I. O’Daniel, Elena Lastochkin, Mayland Chang*, Shahriar Mobashery*. Exploration of the structure-activity relationship of 1, 2, 4-oxadiazole antibiotics. Bioorg. Med. Chem. Lett. 2015, 25, 4854-4857
12. Edward Spin$, Derong Ding$, Zhihong Peng, Marc A. Boudreau, Erika Leemans, Elena Lastochkin, Wei Song, Katerina Lichtenwalter, Peter I. O’Daniel, Sebastian A. Testero, Hualiang Pi, Valerie A. Schroeder, William R. Wolter, Nuno T. Antunes, Mark A. Suckow, Sergei Vakulenko, Mayland Chang*, and Shahriar Mobashery* . Structure-activity relationship for the oxadiazole class of antibiotics. J. Med. Chem. 2015, 58, 1380–1389. ($ Co-first authors)
13. Derong Ding, Justin R. Nickell, Linda P. Dwoskin, Peter A.Crooks*. Quinolyl analogues of norlobelane: novel potent inhibitors of vesicular [3H]dihydrotetrabenazine binding and [3H]dopamine uptake at the vesicular monoamine transporter-2. Bioorg. Med. Chem. Lett. 2015, 25, 2613-2616
14. Peter I. O’Daniel, Zhihong Peng, Hualiang Pi, Sebastian A. Testero, Derong Ding, Edward Spink, Erika Leemans, Marc A. Boudreau, Takao Yamaguchi, Valerie A. Schroeder, William R. Wolter, Leticia I. Llarrull, Wei Song, Elena Lashtochkin, Malika Kumarasiri, Nuno T. Antunes, Mana Espahbodi, Katerina Lichtenwalter, Mark A. Suckow, Sergei Vakulenko, Shahriar Mobashery,* and Mayland Chang*. Discovery of a new class of non-β-lactam inhibitors of penicillin-binding proteins with Gram-positive antibacterial activity. J. Am. Chem. Soc. 2014, 136 , 3664-3672
15. Derong Ding, Katerina Lichtenwalter, Hualiang Pi, Shahriar Mobashery* and Mayland Chang*. Characterization of a selective inhibitor for matrix metalloproteinase-8 (MMP-8). Med. Chem. Commun. 2014, 5, 1381-1383
16. Major Gooyit, Zhihong Peng, William R. Wolter, Hualiang Ping, Derong Ding, Dusan Hesek, Mijoon Lee, Bill Boggess, Matthew M. Champion, Mark A. Suckow, Shahriar Mobashery*, and Mayland Chang*. A chemical biological strategy to facilitate diabetic wound healing. ACS Chem. Biol. 2014, 9,105–110
17. Derong Ding, Justin R. Nickell, Agripina G. Deaciuc, Narsimha Reddy Penthala, Linda P. Dwoskin, Peter A. Crooks*. Synthesis and evaluation of novel azetidine analogs as potent inhibitors of vesicular [3H]dopamine uptake. Bioorg.Med.Chem. 2013, 21, 6771-6777
18. Derong Ding, Linda P. Dwoskin, Peter A Crooks*. Efficient synthesis of cis-2, 6-di-(2-quinolylpiperidine). Tetrahedron Lett. 2013,54, 5211-5213
19. Qi Zhang$, Derong Ding$, Shelya X Zeng, Qi-Zhuang Ye *, Hua Lu*. Structure and activity analysis of Inauhzin analogs as novel antitumor compounds that induce p53 and inhibit cell growth. PLoS ONE 2012, 7, e46294 ($ Co-first authors)
20. Qi Zhang, Shelya X Zeng, Yu Zhang, Yiwei Zhang , Derong Ding, Qi-Zhuang Ye, Samy O. Meroueh and Hua Lu* . A small molecule Inauhzin inhibits SIRT1 activity and suppresses tumor growth through activation of p53. EMBO Mol. Med. 2012 ,4, 298-312

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