Prof. Magdalene J. Seiler

School of Medicine

University of California at Irvine, USA

Professor in Residence

Email: [email protected]

Qualifications

1985  Ph.D., Ludwig-Maximilians-University, Munich, Germany; Neurochemistry; “Neurotrophic factors in CNS”

1982  Diploma, Ludwig-Maximilians-University, Munich, Germany; Biology

Publications(Selected)

1. Lin, B., Schneider, K., Ozgul, M., Ianopol, N. and Seiler, M. Neuroprotective Effect of Intraperitoneal Humanin-G in Retinal Degeneration of Royal College of Surgeons Rats. bioRxiv, 2026.

2. Seiler, M.J., Nguyen, H., Endejan, D., Lin, B., Zhao, G. and Klaskala, L. Generation of a new immunodeficient rat model of retinal degeneration with LSL TdTomato reporter and TdTomato-Pcp2 expression. bioRxiv, 2026.
3. Lim, J., Ung, F., Malhotra, S., Diaz, J.C., Hamilton, A., Chen, C., Tang, W.C. and others. A Novel, Low-Cost, 3D-Printed Motorized Injector for Retinal Sheet Transplantation. Bioengineering, 13(2), 188, 2026.
4. Alizadeh, A.M., Lin, B., Seiler, M. and Lyon, D.C. Restoration of Higher-Order Cortical Processing in Rat V2 by Retinal Sheet Transplants in Degenerated Rats. bioRxiv, 2025.
5. Seiler, M.J., Vo, T., Do, H., Endejan, D., Suon, A., Sims, R., Lin, B., Zhao, G. and others. Generation of a new rat model of retinal degeneration with TdTomato-Pcp2 expression. Investigative Ophthalmology & Visual Science, 66(8), 3823, 2025.
6. Gupta, A., Nair, D.S.R., Joshi, A., Seiler, M.J., John, J.V. and Thomas, B. Engineering and optimization of retinal pigment epithelium-photoreceptor bilayer retinal microtissues using filamented light biofabrication. Investigative Ophthalmology & Visual Science, 66(8), 764, 2025.
7. Lim, J., Ung, F., Diaz, J.C., Hamilton, A., Chen, C., Aguas, R.F., Malhotra, S. and others. Precision and Accuracy of a Novel Motorized 3D Printed Retinal Sheet Injector for Subretinal Transplantation. Investigative Ophthalmology & Visual Science, 66(8), 3585, 2025.
8. Azzam, A., Ung, F., Lim, J., Diaz, J.C., Seiler, M.J. and Browne, A. Motorized Retinal Sheet Injector for Subretinal Transplantation in a Rat Model of Retinal Degeneration. Investigative Ophthalmology & Visual Science, 66(8), 261, 2025.
9. Malhotra, S., Browne, A., Skowronska-Krawczyk, D., Tang, W.C. and Seiler, M.J. Towards Scalable Retinal Organoid Production: A Simplified 2D-3D Protocol Enhances Efficiency. Investigative Ophthalmology & Visual Science, 66(8), 5306, 2025.
10. Malhotra, S., Seiler, M.J. and Browne, A.W. Challenges and Advances in the Production of Transplantable Retinal Tissue from Retinal Organoids. Journal of Ophthalmic & Vision Research, 20, 10.18502/jovr.v20.17499, 2025.
11. Cao, W., Tan, Z., Berackey, B.T., Nguyen, J.K., Brown, S.R., Du, S., Lin, B., Ye, Q. and others. An AAV capsid proposed as microglia-targeting directs genetic expression in forebrain excitatory neurons. Cell Reports Methods, 5(6), 2025.
12. Tang, W.C., Browne, A.W., Seiler, M.J. and Xue, Y. Recent patents relating to the production, culture and use of organoids. Nature Biotechnology, 43(863), 863, 2025.
13. Rajendran Nair, D.S., Seiler, M.J., Martinez-Camarillo, J.C., Xue, Y., Sharma, R. and others. Stem cell-derived co-grafts contribute to retinal reconstruction and visual functional improvement in a laser damaged rat model. Military Medical Research, 12(1), 23, 2025.
14. Thomas, B.B., Nair, D.S.R., Rahimian, M., Hassan, A.K., Tran, T.L. and Seiler, M.J. Animal models for the evaluation of retinal stem cell therapies. Progress in Retinal and Eye Research, 106, 101356, 2025.
15. Sims, R., Lin, B., Xue, Y., Fouda, R., McLelland, B.T., Nistor, G., Keirstead, H.S. and others. Effect of immunosuppression on hESC-derived retina organoids in vitro and in vivo. Stem Cell Research & Therapy, 16(1), 165, 2025.
16. Tang, W.C., Browne, A.W., Seiler, M.J. and Xue, Y. 3D printed micro-millifluidic bioreactors for long-term retinal organoid maintenance. US Patent 12,247,220, 2025.
17. Rajendran Nair, D.S., Gupta, A., Iseri, E., Wei, T., Phuong Quach, L.T., Seiler, M.J. and others. Extrinsic electric field modulates neuronal development and increases photoreceptor population in retinal organoids. Frontiers in Neuroscience, 18, 1438903, 2024.
18. Nair, D.S.R., Iseri, E., Shehi, A., Gupta, A., Krishnagiri, A., Quach, S., Wei, T. and others. Accelerated Retina Organoid Differentiation and Maturation through a Brief Exposure to Electrical Field. Investigative Ophthalmology & Visual Science, 65(7), 4545, 2024.
19. Azzam, A., Sims, R., Kenney, M.C., Kuppermann, B.D. and Seiler, M.J. Safe and Efficient Technique for Organoid/Human Embryonic Stem-cell Derived Retina to Subretinal Space in retinal degenerate Rho S334ter-3 Rats. Investigative Ophthalmology & Visual Science, 65(7), 5383, 2024.
20. Lin, B., Alizadeh, A.M., Sims, R., Azzam, A., Suon, A., Lyon, D. and Seiler, M.J. Retinal progenitor sheet transplants improve vision in a severe retinal degenerate (RD) rat. Investigative Ophthalmology & Visual Science, 65(7), 3916, 2024.

Personal Details

https://www.faculty.uci.edu/profile/?facultyId=6226

https://scholar.google.com/citations?user=oOthnC0AAAAJ&hl=en

https://www.researchgate.net/profile/Magdalene-Seiler

WoS Researcher ID: I-2942-2019