Department of Microbiology-Infectiology and Immunology

Université Laval, Canada

Email:[email protected]

Qualifications

2010  Professor, Dept. of Microbiology-Infectiology and Immunology, Laval University
2009  Associate Professor, Dept. of Anatomy & Physiology, Laval University
2006  Assistant Professor, Dept. of Anatomy & Physiology, Laval University
1997  Ph.D., Biology, Sherbrooke University
1992  M.Sc., Microbiology, Sherbrooke University
1988  B.Sc., Biology (Biotechnology), Sherbrooke University

Publications (Selected)

1. Iqbal, J., Islam, T., al-Rashida, M., Hameed, A., Iftikhar, T., Pelletier, J., ... & Hussain, T. (2025). Pursing Quinoline-8-Sulfonamide derivatives for the identification of potent NPPs inhibitors: In silico molecular docking, molecular dynamics simulations and density field theory (DFT) studies. Results in Chemistry, 102556.
2. Batool, Z., Dutt, S. M., al-Rashida, M., Gelsleichter, N. E., Pelletier, J., Sévigny, J., ... & Iqbal, J. (2025). N-hexylsulfonyl indole based thiosemicarbazones as potent and selective ecto-5′-nucleotidase and NTPDase inhibitors. Bioorganic Chemistry, 108717.
3. Pinto-Cardoso, R., Bessa-Andrês, C., Pereira-Costa, F., Neiva, R., Martins-Ferreira, R., Guerra-Leal, B., ... & Correia-de-Sá, P. (2025). HIF-1α Stabilization Hampers the Chondrogenic Differentiation of Aged Bone Marrow Mesenchymal Stem Cells by Adenosine A2A/A2B Receptors Imbalance. ACS Pharmacology & Translational Science.
4. Ahmad, H., Ullah, S., Abdullah, N., Khan, A. H., Ullah, F., Khan, I. A., ... & Hassan, A. (2025). Synthesis of 1, 3, 4-Oxadiazole Derivatives via Transition Metal Catalyzed Cross-Coupling and their Biological Evaluation as Selective Inhibitors of Ecto-Nucleoside Triphosphate Diphosphohydrolase (NTPDase)-2,-3 and-8 Inhibitors. Journal of Molecular Structure, 142731.
5. da Silva, A. C., Scholl, J. N., de Fraga Dias, A., Weber, A. F., Morrone, F. B., Cruz-Lopez, O., ... & Battastini, A. M. O. (2025). Preclinical evaluation of bozepinib in bladder cancer cell lines: modulation of the NPP1 enzyme. Purinergic signalling, 21(1), 39-50.
6. Wu, X., Chen, P. I., Whitener, R. L., MacDougall, M. S., Coykendall, V. M., Yan, H., ... & Meyer, E. H. (2024). CD39 delineates chimeric antigen receptor regulatory T cell subsets with distinct cytotoxic & regulatory functions against human islets. Frontiers in immunology, 15, 1415102.
7. Tasleem, M., Pelletier, J., Sevigny, J., Hussain, Z., Khan, A., Al-Harrasi, A., ... & Iqbal, J. (2024). Synthesis, in vitro, and in silico studies of morpholine-based thiosemicarbazones as ectonucleotide pyrophosphatase/phosphodiesterase-1 and-3 inhibitors. International Journal of Biological Macromolecules, 266, 131068.
8. Cardoso, A. M., Aneli, N. M., Lammers, M., Mânica, A., Zanini, D., de Oliveira Maciel, S. F. V., ... & De Sá, C. A. (2023). Resistance training reduces platelet activation in hypertensive women: the role of purinergic signaling. Journal of Hypertension, 41(11), 1745-1752.
9. Pelletier, J., Sévigny, J., & Iqbal, J. (2023). Synthesis of new class of indole acetic acid sulfonate derivatives as ectonucleotidases inhibitors†† Electronic supplementary information (ESI) available. See. RSC Advances, 13(42), 29496-29511.
10. Lopez, V., Schuh, H. M., Mirza, S., Vaaßen, V. J., Schmidt, M. S., Sylvester, K., ... & Müller, C. E. (2023). Heparins are potent inhibitors of ectonucleotide pyrophosphatase/phospho-diesterase-1 (NPP1)–a promising target for the immunotherapy of cancer. Frontiers in Immunology, 14, 1173634.
11. Zaman, G., Ullah, S., Uzair, M., Batool, S., Ahmad, H., Ullah, F., ... & Hassan, A. (2023). Synthesis of Thieno [3, 2‐d] pyrimidine Derivatives through Sequential SNAr and Suzuki Reactions as Selective h‐NTPDase Inhibitors. ChemMedChem, 18(14), e202300165.
12. Bi, C., Schäkel, L., Mirza, S., Sylvester, K., Pelletier, J., Lee, S. Y., ... & Müller, C. E. (2023). Synthesis and structure–activity relationships of ticlopidine derivatives and analogs as inhibitors of ectonucleotidase CD39. Bioorganic Chemistry, 135, 106460.

Profile Details

WoS ResearcherID: AGH-9323-2022

https://orcid.org/0000-0003-2922-1600

https://scholar.google.com/citations?user=no4iLwoAAAAJ&hl=fr

https://www.researchgate.net/profile/Jean-Sevigny