Prof. Chunhai Hao

School of Medicine

Indiana University, USA

Bicentennial Professor of Pathology & Laboratory Medicine II

Email: [email protected]

Qualifications

1997 F.R.C.P.C. University of Western Ontario

1991 Ph.D., University of Saskatchewan

1985 M.Sc., Norman Bethune University of Medical Sciences

1981 M.D., Jilin Medical College

Publications (Selected)

1. Jung S, Roy R, Zhao Y Q, et al. Synergistic Antitumor Activity of SUMO1 degrader and Oxaliplatin through G6PD Inhibition in Colorectal Cancer[J]. bioRxiv, 2025: 2025.04. 08.647644.

2. Liu Y, Li Y, Chen L, et al. Construction of an oxidative stress risk model to analyze the correlation between liver cancer and tumor immunity[J]. Current Cancer Drug Targets, 2025, 25(1): 49-63.
3. Witten A J, Dougherty C, Hao C. Diffuse leptomeningeal glioneuronal tumor with distinct neuronal and glial components but identical diagnostic molecular and genetic features[J]. Neuropathology, 2024, 44(6): 440-444.
4. Lancaster M S, Hafen P, Law A S, et al. Sucla2 Knock‐Out in Skeletal Muscle Yields Mouse Model of Mitochondrial Myopathy With Muscle Type–Specific Phenotypes[J]. Journal of Cachexia, Sarcopenia and Muscle, 2024, 15(6): 2729-2742.
5. Liu Y, Hao C, Li L, et al. The role of oxidative stress in the development and therapeutic intervention of hepatocellular carcinoma[J]. Current cancer drug targets, 2023, 23(10): 792-804.
6. Zhao Y Q, Jin H R, Kim D, et al. SUMO1 degrader induces ER stress and ROS accumulation through deSUMOylation of TCF4 and inhibition of its transcription of StarD7 in colon cancer[J]. Molecular carcinogenesis, 2023, 62(9): 1249-1262.
7. Dougherty C, Wohlford R, Jung S, et al. HB007 Administration Inhibits LN-229 and Patient-Derived Neurospheroid Glioblastoma Cell Growth With the Degradation of SUMO1 and Cell Cycle Regulator CDK4[J]. 2023.
8. Jung S, Jaiswal N, Rai R K, et al. Small-molecule degraders reduce Aβ production through CAPRIN1-mediated lysosomal degradation of APP in Alzheimer’s iPSC-derived neurons[J]. bioRxiv, 2023: 2023.12. 29.573648.
9. Mirzaei R, Gordon A, Zemp F J, et al. PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway[J]. Science Advances, 2021, 7(45): eabh2148.
10. Bellail A C, Jin H R, Lo H Y, et al. Ubiquitination and degradation of SUMO1 by small-molecule degraders extends survival of mice with patient-derived tumors[J]. Science translational medicine, 2021, 13(615): eabh1486.

Personal Details

https://medicine.iu.edu/faculty/41288/hao-chunhai

https://scholar.google.com/citations?user=yWN6N0IAAAAJ&hl=en

https://www.linkedin.com/in/chunhai-charlie-hao-md-phd-frcpc-1b269516b/

WoS Researcher ID: CUK-4152-2022