Prof. Sai Ming Ngai

Chinese University of Hong Kong, China

Professor

Email: [email protected]

Qualifications

1988 – 1994 Ph.D. (Biochemistry) University of Alberta, Edmonton, Canada

1984 – 1986 B.Sc. (Honors Biochemistry, Dean’s Honor List) University of Waterloo, Waterloo, Canada

Publications(Selected)

1. Liang, Z., Long, X., Xiong, Z., Wong, P., Huang, S., Chen, S., Zhang, Y., Zhang, L. and others. Macrophages promote immunotherapy resistance of hepatocellular carcinoma through increasing tumor cell lipid availability. Cancer Research, 86(7_Supplement), 3429, 2026.
2. Lui, K.W., Ngai, S.M. and Chan, T.F. Evaluation of Protein Ion Relative Ratio Quantification in Top-down Electrospray Ionization-Mass Spectrometry Using Site-Specific Acetylated Recombinant Histone H3 Proteoforms. Journal of the American Society for Mass Spectrometry, 36(10):2048-2058, 2025.
3. Liang, Z., Wong, P.P.C., Xiong, Z., Zhang, Y., Huang, S., Chen, S., Zhang, L. and others. IDDF2025-ABS-0355 Tumor-associated macrophages enhance tumor cell lipid availability to promote anti-PD-1 resistance of hepatocellular carcinoma. Gut, 74(Suppl 3):A76-A76, 2025.
4. Li, Y., Law, S.T.S., Nong, W., So, W.L., Xie, Y., Leung, T.C.N., Li, T.H., Tse, J., Yip, H.Y. and others. Single-cell analyses reveal scyphozoan conserved and specific genes contribution during tissue regeneration in two jellyfish. bioRxiv, 2025.
5. Yan, L., Lai, H.Y., Leung, T.C.N., Cheng, H.F., Chen, X., Tsui, S.K.W., Ngai, S.M. and others. PE/PPE Proteome and ESX-5 Substrate Spectrum in Mycobacterium marinum. International Journal of Molecular Sciences, 25(17), 9550, 2024.
6. Feng, L., Teng, F., Li, N., Zhang, J.C., Zhang, B.J., Tsai, S.N., Yue, X.L., Gu, L.F. and others. A reference-grade genome of the xerophyte Ammopiptanthus mongolicus sheds light on its evolution history in legumes and drought-tolerance mechanisms. Plant Communications, 5(7), 2024.
7. Liang, J., Hassan, I.U., Cheung, M.Y., Feng, L., Lin, Y., Long, Q., Wang, C., Ding, Y. and others. Mechanistic study of transcription factor Sox18 during heart development. General and comparative endocrinology, 350, 114472, 2024.
8. Leung, T.C.N., Lu, S.N., Chu, C.N., Lee, J., Liu, X. and Ngai, S.M. Temporal Quantitative Proteomic and Phosphoproteomic Profiling of SH-SY5Y and IMR-32 Neuroblastoma Cells during All-Trans-Retinoic Acid-Induced Neuronal Differentiation. International Journal of Molecular Sciences, 25(2), 1047, 2024.
9. Lau, E.S.W., Zhu, B., Sun, M.A., Ngai, S.M. and Ge, W. Proteomic analysis of zebrafish folliculogenesis identifies YB-1 (Ybx1/ybx1) as a potential gatekeeping molecule controlling early ovarian folliculogenesis. Biology of Reproduction, 109(4):482-497, 2023.
10. Chen, Z., Leung, T.C.N., Lui, Y.L., Ngai, S.M. and Chung, H.Y. Combination of untargeted and targeted proteomics for secretome analysis of L-WRN cells. Analytical and Bioanalytical Chemistry, 415(8):1465-1476, 2023.
11. Wan, A.T.Y., Xiong, Q., Xiao, X., Ao, K.F.K., Jang, S.W., Wong, B.S.H., Wang, M. and others. Multi-Omic Analysis of Tyrophagus putrescentiae Reveals Insights into the Allergen Complexity of Storage Mites. bioRxiv, 2022.
12. Wai, C.Y.Y., Leung, N.Y.H., Leung, A.S.Y., Ngai, S.M., Pacharn, P., Yau, Y.S. and others. Comprehending the allergen repertoire of shrimp for precision molecular diagnosis of shrimp allergy. Allergy, 77(10):3041-3051, 2022.
13. Shum, C.W.Y., Nong, W., So, W.L., Li, Y., Qu, Z., Yip, H.Y., Swale, T., Ang, P.O. and others. Genome of the sea anemone Exaiptasia pallida and transcriptome profiles during tentacle regeneration. Frontiers in Cell and Developmental Biology, 10, 900321, 2022.
14. Sin, W.C., Lam, H.M. and Ngai, S.M. Identification of diverse stress-responsive xylem sap peptides in soybean. International Journal of Molecular Sciences, 23(15), 8641, 2022.
15. Huang, T., Hou, Y., Wang, X., Wang, L., Yi, C., Wang, C., Sun, X., Tam, P.K.H. and others. Direct interaction of Sox10 with cadherin-19 mediates early sacral neural crest cell migration: implications for enteric nervous system development defects. Gastroenterology, 162(1):179-192.e11, 2022.
16. So, W.L., Leung, T.C.N., Nong, W., Bendena, W.G., Ngai, S.M. and Hui, J.H.L. Transcriptomic and proteomic analyses of venom glands from scorpions Liocheles australasiae, Mesobuthus martensii, and Scorpio maurus palmatus. Peptides, 146, 170643, 2021.
17. Qu, X., Leung, T.C.N., Ngai, S.M., Tsai, S.N., Thakur, A., Li, W.K., Lee, Y., Leung, L. and others. Proteomic analysis of circulating extracellular vesicles identifies potential biomarkers for lymph node metastasis in oral tongue squamous cell carcinoma. Cells, 10(9), 2179, 2021.
18. Lui, K.W. and Ngai, S.M. PrSM-level side-by-side comparison of online LC-MS methods with intact Histone H3 and H4 proteoforms. Journal of Proteome Research, 20(9):4331-4345, 2021.
19. Xu, Z., Zhang, R., Yang, M., Law, Y.S., Sun, F., Hon, N.L., Ngai, S.M. and Lim, B.L. A balance between the activities of chloroplasts and mitochondria is crucial for optimal plant growth. Antioxidants, 10(6), 935, 2021.
20. Vong, K.I., Ma, T.C., Li, B., Leung, T.C.N., Nong, W., Ngai, S.M., Hui, J.H.L. and others. SOX9-COL9A3–dependent regulation of choroid plexus epithelial polarity governs blood–cerebrospinal fluid barrier integrity. Proceedings of the National Academy of Sciences, 118(6), e2009568118, 2021.

Personal Details

https://webapp3.law.cuhk.edu.hk/conf/20210730/prof-sai-ming-ngai/

https://scholar.google.com/citations?user=uqySJAcAAAAJ&hl=zh-TW

https://www.researchgate.net/profile/Sai-Ming-Ngai

WoS Researcher ID: S-4898-2018