Prof. R. Charles Nichols

University of Florida Proton Therapy Institute, USA

Email: [email protected]

Qualifications

1988 M.D., Georgetown University Medical School

1983 B.A., Georgetown University College of Arts and Sciences

Publications (selected)

1. Henderson, R. H., Bryant, C. M., Nichols, R. C., Jr., et al. (2026). Ten-year outcomes for image-guided moderately hypofractionated proton therapy for prostate cancer. Radiotherapy and Oncology, 219, Article 111482.
2. Fortna, M., Mendenhall, N. P., Lichlyter, D. A., et al. (2025). Long-Term Outcomes Following Proton Therapy for Prostate Cancer in Men Ages 50 and Younger. International Journal of Radiation Oncology Biology Physics, 123(1, Suppl. S), 3226.
3. Lichlyter, D. A., Mendenhall, N. P., Jean-Baptiste, S., et al. (2025). Salvage Proton Therapy after Primary Cryosurgery or HIFU for Prostate Cancer. International Journal of Radiation Oncology Biology Physics, 123(1, Suppl. S), e183.
4. Chhabra, A. M., Amos, Richard A., Simone, C. B., et al. (2025). Proton Beam Therapy for Pancreatic Tumors A Consensus Statement from the Particle Therapy Cooperative Group Gastrointestinal Subcommittee. International Journal of Radiation Oncology Biology Physics, 122(1), 19–30.
5. Henderson, R. H. H., Bryant, C., Nichols, R. C., Jr., et al. (2023). Local salvage of radiorecurrent prostate cancer. Prostate, 83(11), 1001–1010.
6. Geng, H., Liao, Z., Nguyen, Q.-N., et al. (2023). Implementation of Machine Learning Models to Ensure Radiotherapy Quality for Multicenter Clinical Trials: Report from a Phase III Lung Cancer Study. Cancers, 15(4), Article 1014.
7. Amos, R. A., Diffenderfer, E. S., Johnson, J. E. J., et al. (2022). Proton Beam Therapy for Pancreas Cancer: PTCOG Consensus Recommendations for Simulation, Treatment Planning and Treatment Delivery. International Journal of Radiation Oncology Biology Physics, 114(3, Suppl. S), 2423.
8. Hotca, A. E., Sindhu, K., Lehrer, E. J., et al. (2022). Reirradiation with Proton Therapy for Recurrent Malignancies of the Esophagus and Gastroesophageal Junction: Results of the Proton Collaborative Group Multi-Institutional Prospective Registry Trial. International Journal of Radiation Oncology Biology Physics, 114(3, Suppl. S), 2357.
9. Hoppe, B. S., Nichols, R. C., Flampouri, S., et al. (2022). Chemoradiation with Hypofractionated Proton Therapy in Stage II-III Non-Small Cell Lung Cancer: A Proton Collaborative Group Phase 2 Trial. International Journal of Radiation Oncology Biology Physics, 113(4), 732–741.
10. Rapp, C. T., Rutenberg, M. S., Morris, C. G., & Nichols, R. C. (2022). Dose-escalated proton therapy with elective nodal irradiation and concomitant chemotherapy for unresectable, borderline resectable, or medically inoperable pancreatic cancer: a phase II trial. Journal of Gastrointestinal Oncology, 13(3), 1395–1401.
11. Padgett, M., Kharod, S. M., Mercado, C. E., et al. (2022). Patterns-of-care disparities among uninsured versus insured patients with anorectal carcinoma referred for radiotherapy at an Urban Safety-Net Hospital. Journal of Gastrointestinal Oncology, 13(3), 1081–1085.
12. Henderson, R. H., Bryant, C. M., Nichols, R. C., et al. (2022). Five- and seven-year outcomes for image-guided moderately accelerated hypofractionated proton therapy for prostate cancer. Acta Oncologica, 61(4), 468–477.
13. Bryant, C. M., Henderson, R. H., Mendenhall, W. M., et al. (2021). 10-Year Outcomes Following Proton Therapy for Localized Prostate Cancer. International Journal of Radiation Oncology Biology Physics, 111(3, Suppl. S), 2536.
14. Rapp, C., Rutenberg, M. S., Morris, C. G., & Nichols, R. C., Jr. (2021). A Phase II Trial of Escalated Dose Proton Radiotherapy With Elective Nodal Irradiation and Concomitant Chemotherapy for Patients with Unresectable, Borderline Resectable or Medically Inoperable Pancreatic Adenocarcinoma. International Journal of Radiation Oncology Biology Physics, 111(3, Suppl. S), 2092.
15. Su, Z., Henderson, R., Nichols, R., et al. (2021). A comparative study of prostate PTV margins for patients using hydrogel spacer or rectal balloon in proton therapy. Physica Medica-European Journal of Medical Physics, 81, 47–51.
16. Henderson, R. H., Bryant, C. M., Nichols, R. C., Jr., et al. (2020). Five-year Outcomes for Moderately Accelerated Hypofractionated Proton Therapy for Prostate Cancer. International Journal of Radiation Oncology Biology Physics, 108(3, Suppl. S), 4001.
17. Hoppe, B. S., Nichols, R. C., Flampouri, S., et al. (2020). Hypofractionated Proton Therapy with Concurrent Chemotherapy for Locally Advanced Non-Small Cell Lung Cancer: A Phase 1 Trial from the University of Florida and Proton Collaborative Group. International Journal of Radiation Oncology Biology Physics, 107(3), 455–461.
18. Kharod, M. M., Nichols, R. C., Jr., Henderson, R. H., et al. (2020). Image-Guided Hypofractionated Proton Therapy in the Management of Centrally Located Early-Stage Non-Small Cell Lung Cancer. International Journal of Radiation Oncology Biology Physics, 108(3, Suppl. S), 2293.
19. Mendenhall, N. P., Bryant, C. M., Hoppe, B. S., et al. (2020). Ten-Year Outcomes From Three Prospective Clinical Trials Of Image-Guided Proton Therapy In Prostate Cancer. International Journal of Radiation Oncology Biology Physics, 108(3, Suppl. S), 4131.
20. Kharod, S. M., Nichols, R. C., Henderson, R. H., et al. (2020). Image-guided hypofractionated double-scattering proton therapy in the management of centrally-located early-stage non-small cell lung cancer. Acta Oncologica, 59(10), 1164–1170.