Prof. Zhen Cheng

Shanghai Institute of Materia Medica

Professor

Email: [email protected],[email protected]

Qualifications

2001 Ph.D., University of Missouri, Chemistry

1997 M.Sc., China Institute of Atomic Energy, Radiopharmaceutical Chemistry

1990 B.Sc., Sichuan University, Chemistry

Publications (selected)

1. Wang X, Tan Y, Yan J, et al. NIR-II organic fluorophores integrated with blood–brain barrier-penetrating strategies for brain disease theranostics[J]. Coordination Chemistry Reviews, 2026, 551: 217466.

   
   

2. Ma G, Ding Q, Wang Y, et al. Precision Photothermal Therapy at Mild Temperature: NIR‐II Imaging‐Guided, H2O2‐Responsive Stealth Nanobomb[J]. Advanced Healthcare Materials, 2025, 14(26): 2402767.
3. Ding Q, Luo Y, Wu H, et al. PLGA nanomedicine for inflammatory bowel disease: targeted delivery and integrated diagnostics toward precision treatment[J]. Science China Chemistry, 2025: 1-32.
4. Liu S, Dong W, Gao H, et al. Near-Infrared-II Fluorescent Probes for Analytical Applications: From In Vitro Detection to In Vivo Imaging Monitoring[J]. Accounts of Chemical Research, 2025, 58(4): 543-554.
5. Chen L, Chen S L, Yuan Y, et al. Inside Front Cover: Complexity made easy: Aggregation‐induced emission small molecules for cancer diagnosis and phototherapies[J]. Aggregate, 2024, 5(6): e717.
6. Wang Y, Ding Q, Ma G, et al. Mucus-penetrable biomimetic nanoantibiotics for pathogen-induced pneumonia treatment[J]. ACS nano, 2024, 18(45): 31349-31359.
7. Chang B, Chen J, Bao J, et al. Molecularly engineered room-temperature phosphorescence for biomedical application: from the visible toward second near-infrared window[J]. Chemical Reviews, 2023, 123(24): 13966-14037.
8. Cheng Z, Si X, Tan H, et al. Cyanidin-3-O-glucoside and its phenolic metabolites ameliorate intestinal diseases via modulating intestinal mucosal immune system: potential mechanisms and therapeutic strategies[J]. Critical Reviews in Food Science and Nutrition, 2023, 63(11): 1629-1647.
9. Wang S, Shi H, Wang L, et al. Photostable small-molecule NIR-II fluorescent scaffolds that cross the blood–brain barrier for noninvasive brain imaging[J]. Journal of the American Chemical Society, 2022, 144(51): 23668-23676.
10. Shi X, Xu P, Cao C, et al. PET/NIR-II fluorescence imaging and image-guided surgery of glioblastoma using a folate receptor α-targeted dual-modal nanoprobe[J]. European Journal of Nuclear Medicine and Molecular Imaging, 2022, 49(13): 4325-4337.
11. Chen H, Liu L, Qian K, et al. Bioinspired large Stokes shift small molecular dyes for biomedical fluorescence imaging[J]. Science Advances, 2022, 8(31): eabo3289.
12. Ji A, Lou H, Qu C, et al. Acceptor engineering for NIR-II dyes with high photochemical and biomedical performance[J]. nature communications, 2022, 13(1): 3815.
13. Chang B, Li D, Ren Y, et al. A phosphorescent probe for in vivo imaging in the second near-infrared window[J]. Nature Biomedical Engineering, 2022, 6(5): 629-639.
14. Shi X, Zhang Z, Zhang Z, et al. Near-infrared window II fluorescence image-guided surgery of high-grade gliomas prolongs the progression-free survival of patients[J]. IEEE Transactions on Biomedical Engineering, 2021, 69(6): 1889-1900.
15. Yang J, He S, Hu Z, et al. In vivo multifunctional fluorescence imaging using liposome-coated lanthanide nanoparticles in near-infrared-II/IIa/IIb windows[J]. Nano Today, 2021, 38: 101120.
16. Chen H, Shou K, Chen S, et al. Smart self‐assembly amphiphilic cyclopeptide‐dye for near‐infrared window‐II imaging[J]. Advanced Materials, 2021, 33(16): 2006902.
17. Wu X, Suo Y, Shi H, et al. Deep-tissue photothermal therapy using laser illumination at NIR-IIa window[J]. Nano-Micro Letters, 2020, 12(1): 38.
18. Li D, Liu Q, Qi Q, et al. Gold nanoclusters for NIR‐II fluorescence imaging of bones[J]. Small, 2020, 16(43): 2003851.
19. Liang J, Wang H, Ding W, et al. Nanoparticle-enhanced chemo-immunotherapy to trigger robust antitumor immunity[J]. Science advances, 2020, 6(35): eabc3646.
20. Lin J, Tian J, Shu C, et al. Malvidin-3-galactoside from blueberry suppresses the growth and metastasis potential of hepatocellular carcinoma cell Huh-7 by regulating apoptosis and metastases pathways[J]. Food Science and Human Wellness, 2020, 9(2): 136-145.
21. Zhang X, He S, Ding B, et al. Cancer cell membrane-coated rare earth doped nanoparticles for tumor surgery navigation in NIR-II imaging window[J]. Chemical Engineering Journal, 2020, 385: 123959.
22. Hu Z, Fang C, Li B, et al. First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows[J]. Nature biomedical engineering, 2020, 4(3): 259-271.
23. Li D, He S, Wu Y, et al. Excretable lanthanide nanoparticle for biomedical imaging and surgical navigation in the second near‐infrared window[J]. Advanced Science, 2019, 6(23): 1902042.
24. He S, Chen S, Li D, et al. High affinity to skeleton rare earth doped nanoparticles for near-infrared II imaging[J]. Nano Letters, 2019, 19(5): 2985-2992.
25. Ding B, Xiao Y, Zhou H, et al. Polymethine thiopyrylium fluorophores with absorption beyond 1000 nm for biological imaging in the second near-infrared subwindow[J]. Journal of Medicinal Chemistry, 2018, 62(4): 2049-2059.
26. He S, Song J, Qu J, et al. Crucial breakthrough of second near-infrared biological window fluorophores: design and synthesis toward multimodal imaging and theranostics[J]. Chemical Society Reviews, 2018, 47(12): 4258-4278.

Profile Details

https://bme.shanghaitech.edu.cn/bme_en/2021/0205/c9279a87265/page.htm

https://scholar.google.com/citations?hl=en&user=ecLMpPQAAAAJ&view_op=list_works&sortby=pubdate

https://www.researchgate.net/profile/Zhen-Cheng-15

WoS ResearcherID: K-2843-2012