Dr. Arun K. Sharma

Department of Pharmacology

Penn State Hershey Cancer Institute, USA

Professor

Email: [email protected]

Qualifications

1997 Ph.D., Department of Chemistry, North-Eastern Hill University, India

1991 M.Sc., Department of Chemistry, North-Eastern Hill University, India

1989 B.Sc., North-Eastern Hill University, India

Publications (selected)

1. Johnson, H, Narayan, S & Sharma, AK 2024, 'Altering phosphorylation in cancer through PP2A modifiers', Cancer Cell International, vol. 24, no. 1, 11. https://doi.org/10.1186/s12935-023-03193-1
2. Preeti, Raza, A, Sharma, RK, Sharma, AK & Kumar, V 2024, 'Design, Synthesis, Anti-Proliferative, and Apoptotic Assessment of Spirocyclopropyl Oxindole–Isatin Hybrids on Triple-Negative Breast Cancer', Chemistry and Biodiversity. https://doi.org/10.1002/cbdv.202402910
3. Nakka, S, Raza, A, Chaitanya, KS, Bandaru, NVMR, Chandu, A, Murugesan, S, Devunuri, N, Sharma, AK & Chandrasekhar, KVG 2024, 'Design, synthesis, and biological evaluation of novel quinoxaline aryl ethers as anticancer agents', Chemical Biology and Drug Design, vol. 103, no. 3, e14502. https://doi.org/10.1111/cbdd.14502
4. Singh, A, Singh, V, Wallis, N, Abis, G, Oberman, F, Wood, T, Dhamdhere, M, Gershon, T, Ramos, A, Yisraeli, J, Spiegelman, VS & Sharma, AK 2024, 'Development of a specific and potent IGF2BP1 inhibitor: A promising therapeutic agent for IGF2BP1-expressing cancers', European Journal of Medicinal Chemistry, vol. 263, 115940. https://doi.org/10.1016/j.ejmech.2023.115940
5. Dhawan, S, Singh, A, Manhas, N, Seboletswe, P, Khubone, L, Kumar, G, Jonnalagadda, SB, Raza, A, Sharma, AK & Singh, P 2024, 'Exploring Novel Coumarin-Tethered Bis-Triazoles: Apoptosis Induction in Human Pancreatic Cancer Cells, Antimicrobial Effects, and Molecular Modelling Investigations', ChemMedChem, vol. 19, no. 22, e202400297. https://doi.org/10.1002/cmdc.202400297
6. Morán-Serradilla, C, Plano, D, Sharma, AK & Sanmartín, C 2024, 'Following the Trace of Cyclodextrins on the Selenium and Tellurium Odyssey', International journal of molecular sciences, vol. 25, no. 14, 7799. https://doi.org/10.3390/ijms25147799
7. Ramos-Inza, S, Morán-Serradilla, C, Gaviria-Soteras, L, Sharma, AK, Plano, D, Sanmartín, C & Font, M 2024, 'Formulation Studies with Cyclodextrins for Novel Selenium NSAID Derivatives', International journal of molecular sciences, vol. 25, no. 3, 1532. https://doi.org/10.3390/ijms25031532
8. Gowda, K, Raza, A, Vangala, V, Lone, NA, Lin, JM, Singh, JK, Srivastava, SK, Schell, TD, Robertson, GP, Amin, S & Sharma, AK 2024, 'Identification of Novel Isatin Derivative Bearing a Nitrofuran Moiety as Potent Multi-Isoform Aldehyde Dehydrogenase Inhibitor', Molecules, vol. 29, no. 13, 3114. https://doi.org/10.3390/molecules29133114
9. Johnson, H, Singh, A, Raza, A, Sha, CM, Wang, J, Gowda, K, Shen, Z, Nair, H, Li, C, Dokholyan, NV, Narayan, S & Sharma, AK 2024, 'Identification of a Novel Protein Phosphatase 2A Activator, PPA24, as a Potential Therapeutic for FOLFOX-Resistant Colorectal Cancer', Journal of Medicinal Chemistry, vol. 67, no. 20, pp. 18070-18089. https://doi.org/10.1021/acs.jmedchem.4c01077
10. Chowdhary, S, Raza, A, Preeti, Kaur, S, Anand, A, Sharma, AK & Kumar, V 2024, 'Isatin-indoloquinoxaline click adducts with a potential to overcome platinum-based drug-resistance in ovarian cancer', Bioorganic Chemistry, vol. 142, 106953. https://doi.org/10.1016/j.bioorg.2023.106953
11. Krishna Rao, V, Paul, S, Gulkis, M, Shen, Z, Nair, H, Singh, A, Li, C, Sharma, AK, Çağlayan, M, Das, C, Das, B, Kundu, CN, Narayan, S & Guchhait, SK 2024, 'Molecular editing of NSC-666719 enabling discovery of benzodithiazinedioxide-guanidines as anticancer agents', RSC Medicinal Chemistry, vol. 15, no. 3, pp. 937-962. https://doi.org/10.1039/d3md00648d
12. Tyagi, A, Chandrasekaran, B, Shukla, V, Tyagi, N, Sharma, AK & Damodaran, C 2024, 'Nutraceuticals target androgen receptor-splice variants (AR-SV) to manage castration resistant prostate cancer (CRPC)', Pharmacology and Therapeutics, vol. 264, 108743. https://doi.org/10.1016/j.pharmthera.2024.108743
13. Chen, YC, Gowda, K, Amin, S, Schell, TD, Sharma, AK & Robertson, GP 2024, 'Pharmacological agents targeting drug-tolerant persister cells in cancer', Pharmacological Research, vol. 203, 107163. https://doi.org/10.1016/j.phrs.2024.107163
14. Singh, V, Singh, A, Liu, AJ, Fuchs, SY, Sharma, A & Spiegelman, VS 2024, 'RNA Binding Proteins as Potential Therapeutic Targets in Colorectal Cancer', Cancers, vol. 16, no. 20, 3502. https://doi.org/10.3390/cancers16203502
15. Swati, Raza, A, Chowdhary, S, Anand, A, Shaveta, , Sharma, AK, Kumar, K & Kumar, V 2024, 'Rational Design and Synthesis of Isatin-Chalcone Hybrids Integrated with 1H-1,2,3-Triazole: Anti-Proliferative Profiling and Molecular Docking Insights', ChemMedChem, vol. 19, no. 14, e202400015. https://doi.org/10.1002/cmdc.202400015
16. Morán-Serradilla, C, Sanmartín, C, Sharma, AK & Plano, D 2024, Selenium and small molecules: a symbiotic partnership. in Drug Discovery Stories: From Bench to Bedside. Elsevier, pp. 217-232. https://doi.org/10.1016/B978-0-443-23932-8.00012-1
17. Morán-Serradilla, C, Plano, D, Sanmartín, C & Sharma, AK 2024, 'Selenization of Small Molecule Drugs: A New Player on the Board', Journal of Medicinal Chemistry, vol. 67, no. 10, pp. 7759-7787. https://doi.org/10.1021/acs.jmedchem.3c02426
18. Angulo-Elizari, E, Raza, A, Encío, I, Sharma, AK, Sanmartín, C & Plano, D 2024, 'Seleno-Warfare against Cancer: Decoding Antitumor Activity of Novel Acylselenoureas and Se-Acylisoselenoureas', Pharmaceutics, vol. 16, no. 2, 272. https://doi.org/10.3390/pharmaceutics16020272
19. Vangala, V, Chen, YC, Dinavahi, SS, Gowda, K, Lone, NA, Herlyn, M, Drabick, J, Helm, K, Zhu, J, Neves, RI, Sharma, AK, Berg, A, Archetti, M, Amin, S, Schell, TD & Robertson, GP 2024, 'Tumor Heterogeneity Shapes Survival Dynamics in Drug-Treated Cells, Revealing Size-Drifting Subpopulations', ACS Pharmacology and Translational Science, vol. 7, no. 11, pp. 3573-3584. https://doi.org/10.1021/acsptsci.4c00453
20. Saran, U, Chandrasekaran, B, Tyagi, A, Shukla, V, Singh, A, Sharma, AK & Damodaran, C 2023, 'A small molecule inhibitor of Notch1 modulates stemness and suppresses breast cancer cell growth', Frontiers in Pharmacology, vol. 14, 1150774. https://doi.org/10.3389/fphar.2023.1150774

Profile Details

https://pure.psu.edu/en/persons/arun-sharma