Prof. Elias J. Fernandez

University of Tennessee, USA

Associate Professor

Email: [email protected]

Qualifications

1995  Ph.D., Loyola University Chicago, Biophysical Chemistry

1988  B.Sc./M.Sc., Bangalore University, Physics with Chemistry & Mathematics

Publications (selected)

1. Harnish M T, Pham B, Arons A, et al. Conformational transition of a polycationic hinge domain contributes to DNA binding[J]. Biophysical Chemistry, 2025: 107531.

2. Lohry D P, Stevens T A, Shen T, et al. Hormone response elements for the thyroid receptor-α include specific distal 5′-flanking DNA[J]. Science Advances, 2024, 10(48): eadr1033.
3. Kwon J, Hu R, Penicks A K, et al. Replacement of P1 of soybean mosaic virus with P1 of clover yellow vein virus has no impact on virus viability and host specificity[J]. Archives of Virology, 2024, 169(7): 143.
4. Harnish M T, Lopez D, Morrison C T, et al. Novel covalent modifier-induced local conformational changes within the intrinsically disordered region of the androgen receptor[J]. biology, 2023, 12(11): 1442.
5. Fernandez E, Lohry D, Dompreh B, et al. Allostery and dynamics in nuclear hormone receptor transactivation[C]//FEBS OPEN BIO. 111 RIVER ST, HOBOKEN 07030-5774, NJ USA: WILEY, 2022, 12: 248-249.
6. Lohry D, Stevens T, Shen T, et al. Interactions Between Intrinsically Disordered Domains of Nuclear Receptors and DNA Studied with Single‐Molecule Optical Tweezers, Computational Simulations, and Cell Assays[J]. The FASEB Journal, 2021, 35.
7. Ponnusamy S, He Y, Hwang D J, et al. Orally bioavailable androgen receptor degrader, potential next-generation therapeutic for enzalutamide-resistant prostate cancer[J]. Clinical Cancer Research, 2019, 25(22): 6764-6780.
8. Pham B, Arons A B, Vincent J G, et al. Regulatory mechanics of constitutive androstane receptors: basal and ligand-directed actions[J]. Journal of chemical information and modeling, 2019, 59(12): 5174-5182.
9. Chen T, Wagner A S, Tams R N, et al. Lrg1 regulates β (1, 3)-glucan masking in Candida albicans through the Cek1 MAP kinase pathway[J]. MBio, 2019, 10(5): 10.1128/mbio. 01767-19.
10. Shmarakov I O, Jiang H, Liu J, et al. Hepatic stellate cell activation: a source for bioactive lipids[J]. Biochimica et Biophysica Acta (BBA)-Molecular and Cell Biology of Lipids, 2019, 1864(5): 629-642.
11. Fernandez E J. Allosteric pathways in nuclear receptors—potential targets for drug design[J]. Pharmacology & therapeutics, 2018, 183: 152-159.

Profile Details

https://bcmb.utk.edu/people/elias-fernandez/

https://scholar.google.com/citations?user=RyfObeUAAAAJ&hl=en

https://www.researchgate.net/profile/Elias-Fernandez

WoS Researcher ID: PBF-9995-2025