Dr. Mahendra D. Chordia

Department of Chemistry

University of Virginia, USA

Senior Research Scientist

Email: [email protected]

Qualifications

1991  Ph.D., Natural Product-Organic Chemistry, University of Pune, India

1985  M.Sc., Organic Chemistry, University of Pune, India

1983  B.Sc., Chemistry, University of Pune, India

Publications (selected)

1. Bhandari, S., Ongwae, G. M., Dash, R., et al. (2026). A generalizable assay for intracellular accumulation to profile cytosolic drug delivery in mammalian cells. Communications Chemistry, 9(1), Article 94.
2. Ongwae, G. M., Liu, Z. C., Feng, S. S., et al. (2026). Click-based determination of accumulation of molecules in Escherichia coli. Nature Communications, 17(1), Article 2008.
3. Wittle, L., Ocius, K. L., Chordia, M. D., et al. (2026). Identification and Evaluation of Benzimidazole- Agonists of Innate Immune Receptor NOD2. ACS Infectious Diseases, 12(2), 600–610.
4. Newkirk, S. E., Kelly, Joey J., Chordia, M. D., et al. (2025). Small Molecule Modulation of MHC-I Surface Expression: A Click Chemistry-Based Discovery Approach. Journal of Medicinal Chemistry, 68(21), 22301–22311.
5. Dash, R., Liu, Z. C., Lepori, I., et al. (2025). Systematic Determination of the Impact of Structural Edits on Peptide Accumulation into Mycobacteria. ACS Chemical Biology, 20(8), 1962–1979.
6. Lepori, I., Jackson, K., Liu, Z. C., et al. (2025). The Mycomembrane Differentially and Heterogeneously Restricts Antibiotic Permeation. ACS Infectious Diseases, 11(7), 1893–1906.
7. Ou, Y., Wang, R. X., Xiao, L., et al. (2025). Tumor targeting chlorin e6 heptamethine cyanine conjugates: Theranostic agent for cancer imaging and photodynamic therapy. Journal of Clinical Oncology, 43(16_suppl), e15132.
8. Li, Q. Y., Zhao, Y. M., Chordia, M. D., et al. (2025). Enhanced prediction of antigen and antibody binding interface using ESM-2 and Bi-LSTM. Human Immunology, 86(3), Article 111304.
9. Pal, A., & Chordia, M. D. (2025). Effect of Atomic Size and Stereochemistry of Halogenated Hydantoin Derivatives on Main Protease Inhibition Activities of SARS-CoV-2: Rationalization Through Computational Studies. IEEE Transactions on Computational Biology and Bioinformatics, 22(1), 240–249.
10. Rastogi, R., Marsh, K., Zhang, A. Y., et al. (2024). Targeted Antioxidant Therapy Reduces Hyperglycemic Exacerbation of Myocardial Ischemia-Reperfusion. Journal of Surgical Research, 301, 554–562.
11. Dash, R., Holsinger, K. A., Chordia, M. D., et al. (2024). Bioluminescence-Based Determination of Cytosolic Accumulation of Antibiotics in Escherichia coli. ACS Infectious Diseases, 10(5), 1602–1611.
12. Ocius, K. L., Kolli, S. H., Ahmad, S. S., et al. (2024). Noninvasive Analysis of Peptidoglycan from Living Animals. Bioconjugate Chemistry, 35(4), 489–498.
13. Kelly, J. J., Dalesandro, B. E., Liu, Z. C., et al. (2024). Measurement of Accumulation of Antibiotics to Staphylococcus aureus in Phagosomes of Live Macrophages. Angewandte Chemie-International Edition, 63(3), Article e202313870.
14. Li, J., Minczuk, K., Huang, Q., et al. (2023). Progressive Cardiac Metabolic Defects Accompany Diastolic and Severe Systolic Dysfunction in Spontaneously Hypertensive Rat Hearts. Journal of the American Heart Association, 12(10), Article e026950.
15. Liu, Z. C., Lepori, I., Chordia, M. D., et al. (2023). A Metabolic-Tag-Based Method for Assessing the Permeation of Small Molecules Across the Mycomembrane in Live Mycobacteria. Angewandte Chemie-International Edition, 62(20), Article e202217777.
16. Ongwae, G. M., Lepori, I., Chordia, M. D., et al. (2022). Measurement of Small Molecule Accumulation into Diderm Bacteria. ACS Infectious Diseases. Advance online publication.
17. Apostolos, AJ., Chordia, M. D., Kolli, S. H., et al. (2022). Real-time non-invasive fluorescence imaging of gut commensal bacteria to detect dynamic changes in the microbiome of live mice. Cell Chemical Biology, 29(12), 1721–1725.
18. Ongwae, G. M., Chordia, M. D., Cawley, J. L., et al. (2022). Targeting of Pseudomonas aeruginosa cell surface via GP12, an Escherichia coli specific bacteriophage protein. Scientific Reports, 12(1), Article 721.
19. Li, J., Chordia, M. D., Zhang, Y., et al. (2022). Critical role of FPR1 in splenocyte migration into brain to worsen inflammation and ischemic brain injury in mice. Theranostics, 12(7), 3024–3044.
20. Wilson, K. B., Nedzbala, H. S., Simpson, S. R., et al. (2021). Hydroamination of Dihapto-Coordinated Benzene and Diene Complexes of Tungsten: Fundamental Studies and the Synthesis of γ-Lycorane. Helvetica Chimica Acta, 104(10), Article e2100103.

Profile Details

https://scholar.google.com/citations?user=RnynmssAAAAJ&hl=en
https://www.researchgate.net/profile/Mahendra-Chordia

WOS ResearcherID: A-4706-2008