Dr. Georgi V. Petkov

Department of Pharmaceutical and Biomedical Sciences

South Carolina College of Pharmacy (SCCP)

University of South Carolina (USC), Columbia

Associate Professor

E-mail: [email protected]

Qualifications

1997 Ph.D., Physiology, University of Sofia, Sofia, Bulgaria

1992 M.Sc., Biochemistry and Microbiology, University of Sofia, Bulgaria

Publications (selected)

1. Malysz, John & Maxwell, Sarah & Petkov, Georgi. (2022). Differential effects of TRPM4 channel inhibitors on Guinea pig urinary bladder smooth muscle excitability and contractility: Novel 4‐chloro‐2‐[2‐(2‐chloro‐phenoxy)‐acetylamino]‐benzoic acid (CBA) versus classical 9‐phenanthrol. Pharmacology Research & Perspectives. 10. 10.1002/prp2.982. 
2. Maxwell, Sarah & Malysz, John & Leo, M. Dennis & Xin, Wenkuan & Park, Frank & Petkov, Georgi. (2021). K V 7 Channel Subtype Expression and Physiological Roles in Rat Urinary Bladder Smooth Muscle Excitability and Contractility. The FASEB Journal. 35. 10.1096/fasebj.2021.35.S1.04481. 
3. Maxwell, Sarah & Leo, M. Dennis & Malysz, John & Petkov, Georgi. (2021). Age‐dependent decrease in TRPM4 channel expression but not trafficking alters urinary bladder smooth muscle contractility. Physiological Reports. 9. 10.14814/phy2.14754. 
4. Malysz, John & Petkov, Georgi. (2020). Detrusor Smooth Muscle KV7 Channels: Emerging New Regulators of Urinary Bladder Function. Frontiers in Physiology. 11. 1004. 10.3389/fphys.2020.01004. 
5. Malysz, John & Petkov, Georgi. (2020). Urinary bladder smooth muscle ion channels: expression, function, and regulation in health and disease. American Journal of Physiology-Renal Physiology. 319. 10.1152/ajprenal.00048.2020. 
6. Malysz, John & Maxwell, Sarah & Petkov, Georgi. (2020). Distinct Age‐dependent Effects of Glibenclamide on Guinea Pig Urinary Bladder Smooth Muscle Non‐selective Cation Currents and Spontaneous Phasic Contractions. The FASEB Journal. 34. 1-1. 10.1096/fasebj.2020.34.s1.04129. 
7. Malysz, John & Rovner, Eric & Wake, Robert & Petkov, Georgi. (2020). A Method for Preparation of Freshly-Isolated Human Urinary Bladder Smooth Muscle Cells: Utility for Characterization of Whole-Cell Cation Currents. Biophysical Journal. 118. 591a. 10.1016/j.bpj.2019.11.3202. 
8. Malysz, John & Rovner, Eric & Wake, Robert & Petkov, Georgi. (2020). Preparation and Utilization of Freshly Isolated Human Detrusor Smooth Muscle Cells for Characterization of 9-Phenanthrol-Sensitive Cation Currents. Journal of Visualized Experiments. 10.3791/59884. 
9. Malysz, John & Maxwell, Sarah & Yarotskyy, Viktor & Petkov, Georgi. (2019). TRPM4 channel inhibitors 9-phenanthrol and glibenclamide differentially decrease guinea pig detrusor smooth muscle whole-cell cation currents and contractions. American Journal of Physiology-Cell Physiology. 318. 10.1152/ajpcell.00055.2019.
   
10. Yarotskyy, Viktor & Malysz, John & Petkov, Georgi. (2019). Extracellular pH and Intracellular Phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2) Control Cl- Currents in Guinea Pig Detrusor Smooth Muscle Cells. American Journal of Physiology-Cell Physiology. 317. 10.1152/ajpcell.00189.2019. 
11. Malysz, John & Maxwell, Sarah & Yarotskyy, Viktor & Petkov, Georgi. (2019). Compound-dependent Effects of TRPM4 Channel Modulators on Guinea Pig Detrusor Smooth Muscle Excitability and Contractility. The FASEB Journal. 33. 837.4-837.4. 10.1096/fasebj.2019.33.1_supplement.837.4. 
12. Yarotskyy, Viktor & Petkov, Georgi. (2019). Extracellular pH But Not Osmotic Pressure Modulates Cl− Current in Freshly-Isolated Guinea Pig Detrusor Smooth Muscle Cells. Biophysical Journal. 116. 99a. 10.1016/j.bpj.2018.11.570. 
13. Yarotskyy, Viktor & Malysz, John & Petkov, Georgi. (2018). Properties of Single Channel and Whole-Cell Cl - Currents in Guinea Pig Detrusor Smooth Muscle Cells. American Journal of Physiology-Cell Physiology. 316. 10.1152/ajpcell.00327.2018. 
14. Provence, Aaron & Angoli, Damiano & Petkov, Georgi. (2018). The Novel and Selective K V 7 Channel Activator, ML213, Reveals Key Physiological Roles for K V 7.4 and K V 7.5 Channel Subtypes in Guinea Pig Detrusor Smooth Muscle Function. The FASEB Journal. 31. 10.1096/fasebj.31.1_supplement.690.2. 
15. Yarotskyy, Viktor & Malysz, John & Petkov, Georgi. (2018). Chloride Single Channel Activity in Freshly‐Isolated Guinea Pig Detrusor Smooth Muscle Cells. The FASEB Journal. 32. 10.1096/fasebj.2018.32.1_supplement.770.13. 
16. Provence, Aaron & Angoli, Damiano & Petkov, Georgi. (2017). K V 7 Channel Activation by the Novel Activator ML213: Role for Heteromeric K V 7.4/K V 7.5 Channels in Guinea Pig Detrusor Smooth Muscle Function. Journal of Pharmacology and Experimental Therapeutics. 364. jpet.117.243162. 10.1124/jpet.117.243162. 
17. Provence, Aaron & Rovner, Eric & Petkov, Georgi. (2017). Regulation of Transient Receptor Potential Melastatin 4 Channel by Sarcoplasmic Reticulum Inositol Triphosphate Receptors: Role in Human Detrusor Smooth Muscle Function. Channels (Austin, Tex.). 23. 1-8. 10.1080/19336950.2017.1341023. 
18. Hristov, Kiril & Parajuli, Shankar & Provence, Aaron & Rovner, Eric & Petkov, Georgi. (2017). Non-genomic modulation of the large conductance voltage- and Ca2+-activated K+ channels by estrogen: A novel regulatory mechanism in human detrusor smooth muscle. Physiological Reports. 6. e13351. 10.14814/phy2.13351. 
19. Provence, Aaron & Angoli, Damiano & Petkov, Georgi. (2016). AB317. SPR-44 Pharmacological activation of individual KCNQ channel subtypes in detrusor smooth muscle represents a promising novel approach for overactive bladder treatment. Translational Andrology and Urology. 5. AB317-AB317. 10.21037/tau.2016.s317. 
20. Hristov, Kiril & Parajuli, Shankar & Provence, Aaron & Petkov, Georgi. (2016). Testosterone decreases urinary bladder smooth muscle excitability via novel signaling mechanism involving direct activation of the BK channels. American Journal of Physiology - Renal Physiology. 311. ajprenal.00238.2016. 10.1152/ajprenal.00238.2016. 

Profile Details

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