Prof. YanPing Yu

University of Pittsburgh, U.S.A.

Associate Professor of Pathology

Email: [email protected]

Qualifications

1995 Ph.D., University of Maryland at Baltimore, School of Medicine, USA

1987 M.Sc., Sun Yat-Sen University of Medical Science, China

1982 M.D. Medicine, Guangzhou Medical Institute, China

Publications (Selected)

1. Wang, W., Liu, J.J., Li, Y., Ko, S., Feng, N., Zhang, M., Lin, Q., Xia, M., Yu, Y.P., Luo, J.H. and others. IFDlong: a model-based isoform and fusion detector for accurate annotation and quantification of long-read RNA-seq data. Genome Biology, 2026.
2. Luo, J., Michalopoulos, G., Nelson, J.B., Liu, S. and Yu, Y. Systems and methods for predicting prostate cancer recurrence. US Patent App. 19/031,575, 2025.
3. Yu, Y.P., Obert, C., Ren, B.G., Krivit, M., Metcalfe, K., Liu, J.J., Ben-Yehezkel, T. and others. Deep spatial sequencing revealing differential immune responses in human hepatocellular carcinoma. Frontiers in Cell and Developmental Biology, 13, 1600129, 2025.
4. Luo, J., Singhi, A.D., Ren, B., Tseng, C.C., Michalopoulos, G., Nalesnik, M.A. and others. Machine learning-based systems and methods for predicting liver cancer recurrence in liver transplant patients. US Patent App. 18/688,105, 2024.
5. Liu, S., Obert, C., Yu, Y.P., Zhao, J., Ren, B.G., Liu, J.J., Wiseman, K., Krajacich, B.J. and others. Utility analyses of AVITI sequencing chemistry. BMC Genomics, 25(1), 778, 2024.
6. Kader, M., Yu, Y.P., Liu, S. and Luo, J.H. Immuno-targeting the ectopic phosphorylation sites of PDGFRA generated by MAN2A1-FER fusion in HCC. Hepatology Communications, 8(8), e0511, 2024.
7. Yu, Y.P., Liu, S., Geller, D. and Luo, J.H. Serum fusion transcripts to assess the risk of hepatocellular carcinoma and the impact of cancer treatment through machine learning. The American Journal of Pathology, 194(7):1262-1271, 2024.
8. Wang, W., Li, Y., Ko, S., Feng, N., Zhang, M., Liu, J.J., Zheng, S., Ren, B., Yu, Y.P. and others. IFDlong: an isoform and fusion detector for accurate annotation and quantification of long-read RNA-seq data. bioRxiv, 2024.
9. Luo, J.H., Kader, M., Liu, S. and Yu, Y.P. Immune Targeting MAN2A1-FER Kinase Substrates. American Journal of Pathology, 194(4), S14, 2024.
10. Kader, M., Sun, W., Ren, B.G., Yu, Y.P., Tao, J., Foley, L.M., Liu, S., Monga, S.P. and others. Therapeutic targeting at genome mutations of liver cancer by the insertion of HSV1 thymidine kinase through Cas9-mediated editing. Hepatology Communications, 8(4), e0412, 2024.
11. Luo, J.H., Yu, Y.P., Liu, S. and Geller, D. Serum fusion gene transcripts to predict liver cancer. Cancer Research, 84(6_Supplement), 7293, 2024.
12. Liu, Z., Annarapu, G., Yazdani, H.O., Wang, Q., Liu, S., Luo, J.H., Yu, Y.P., Ren, B. and others. Restoring glucose balance: Conditional HMGB1 knockdown mitigates hyperglycemia in a Streptozotocin induced mouse model. Heliyon, 10(1), 2024.
13. Liu, S., Yu, Y.P., Ren, B.G., Ben-Yehezkel, T., Obert, C., Smith, M., Wang, W. and others. Long-read single-cell sequencing reveals expressions of hypermutation clusters of isoforms in human liver cancer cells. eLife, 12, RP87607, 2024.
14. Luo, J.H., Liu, S., Ren, B.G. and Yu, Y.P. Abstract LB253: Long-read single-cell sequencing of liver cancer. Cancer Research, 83(8_Supplement), LB253, 2023.
15. Yu, Y.P., Liu, S., Ren, B.G., Nelson, J., Jarrard, D., Brooks, J.D., Michalopoulos, G. and others. Fusion gene detection in prostate cancer samples enhances the prediction of prostate cancer clinical outcomes from radical prostatectomy through machine learning in a multi-cohort study. The American Journal of Pathology, 193(4):392-403, 2023.
16. Fields, A.T., Andraska, E.A., Kaltenmeier, C., Matthay, Z.A., Herrera, K. and others. Effects of the circulating environment of COVID-19 on platelet and neutrophil behavior. Frontiers in Immunology, 14, 1130288, 2023.
17. Luo, J., Chen, Z., Yu, Y., Michalopoulos, G., Nelson, J.B. and Tseng, C.C. Methods of treating cells containing fusion genes by genomic targeting. US Patent 11,517,629, 2022.
18. Luo, J., Chen, Z., Yu, Y., Michalopoulos, G. and Nelson, J.B. Methods of treating cancers containing fusion genes. US Patent App. 17/751,152, 2022.
19. Liu, Z., Liu, S., Luo, J.H., Yu, Y.P., Ren, B., Annarapu, G., Akinbode, D. and others. Bulk RNA Seq Identifies Activation of Oxidative Stress Regulating Glucose/lipid Metabolism as Potential Mechanism of Increased Glucose Sensitivity Under Conditional Knockdown of HMGB1. American Journal of Pathology, 192(9), S9, 2022.
20. Luo, J., Chen, Z., Yu, Y., Michalopoulos, G. and Nelson, J.B. Methods of treating cancers containing fusion genes. US Patent 11,384,400, 2022.

Personal Details

https://www.path.pitt.edu/people/yan-ping-yu-md-phd

https://scholar.google.com/citations?user=IWUJh3YAAAAJ&hl=en