Dr. Jiyan Ma

Chinese Institute for Brain Research, China

Email: [email protected]

Qualifications

1997 Ph.D., University of Illinois at Chicago
1990 Master of Medicine, Shanghai Medical University

1987 Bachelor of Medicine, Shanghai Medical University

Publications (Selected)

1. Zhang, J., Wang, M., Wang, D., Zhang, X., Ma, Y., Pardon, E., ... & Ma, J. (2025). Investigating the In Vivo Effects of Anti-Prion Protein Nanobodies on Prion Disease with AAV Vector. Pathogens, 14(2), 131.
2. Yan, R., Zhang, Y., Zhang, H., & Ma, J. (2025). Nanobody fusion enhances production of difficult-to-produce secretory proteins. Journal of Biological Chemistry, 108292.
3. Zhang, Y., Yan, R., Zhang, X., & Ma, J. (2024). Disease-Associated Q159X Mutant Prion Protein Is Sufficient to Cause Fatal Degenerative Disease in Mice. Molecular Neurobiology, 1-12.
4. Parmasad, J. L. A., Ricke, K. M., Nguyen, B., Stykel, M. G., Buchner-Duby, B., Bruce, A., ... & Rousseaux, M. W. (2024). Genetic and pharmacological reduction of CDK14 mitigates synucleinopathy. Cell Death & Disease, 15(4), 246.
5. Dues, D. J., Nguyen, A. P. T., Becker, K., Ma, J., & Moore, D. J. (2023). Hippocampal subfield vulnerability to α-synuclein pathology precedes neurodegeneration and cognitive dysfunction. npj Parkinson's Disease, 9(1), 125.
6. Zhang, H., d'Agostino, C., Tulisiak, C., Thorwald, M. A., Bergkvist, L., Lindquist, A., ... & Brundin, P. (2023). Air pollution nanoparticle and alpha-synuclein fibrils synergistically decrease glutamate receptor A1, depending upon nPM batch activity. Heliyon, 9(4).
7. Block, A. J., York, T. C., Benedict, R., Ma, J., & Bartz, J. C. (2023). Prion protein amino acid sequence influences formation of authentic synthetic PrPSc. Scientific reports, 13(1), 441.
8. Ma, J., Zhang, J., & Yan, R. (2022). Recombinant mammalian prions: The “correctly” misfolded prion protein conformers. Viruses, 14(9), 1940.
9. Zhang, H., d'Agostino, C., Tulisiak, C., Thorwald, M. A., Bergkvist, L., Lindquist, A., ... & Brundin, P. (2023). Air pollution nanoparticle and alpha-synuclein fibrils synergistically decrease glutamate receptor A1, depending upon nPM batch activity. Heliyon, 9(4).
10. Zhang, X., Pan, Y. H., Chen, Y., Pan, C., Ma, J., Yuan, C., ... & Ma, J. (2021). The protease-sensitive N-terminal polybasic region of prion protein modulates its conversion to the pathogenic prion conformer. Journal of Biological Chemistry, 297(5), 101344.
11. Block, A. J., Shikiya, R. A., Eckland, T. E., Kincaid, A. E., Walters, R. W., Ma, J., & Bartz, J. C. (2021). Efficient interspecies transmission of synthetic prions. PLoS pathogens, 17(7), e1009765.
12. Bargar, C., Wang, W., Gunzler, S. A., LeFevre, A., Wang, Z., Lerner, A. J., ... & Chen, S. G. (2021). Streamlined alpha-synuclein RT-QuIC assay for various biospecimens in Parkinson’s disease and dementia with Lewy bodies. Acta neuropathologica communications, 9, 1-13.
13. Bergkvist, L., Johnson, M. E., Mercado, G., Steiner, J. A., Meyerdirk, L., Schulz, E., ... & Brundin, P. (2021). An extended release GLP-1 analogue increases α-synuclein accumulation in a mouse model of prodromal Parkinson's disease. Experimental neurology, 341, 113693.
14. George, S., Tyson, T., Rey, N. L., Sheridan, R., Peelaerts, W., Becker, K., ... & Brundin, P. (2021). T cells limit accumulation of aggregate pathology following intrastriatal injection of α-synuclein fibrils. Journal of Parkinson’s Disease, 11(2), 585-603.
15. Peelaerts, W., Bergkvist, L., George, S., Johnson, M., Meyerdirk, L., Schulz, E., ... & Brundin, P. (2020). Inhibiting the mitochondrial pyruvate carrier does not ameliorate synucleinopathy in the absence of inflammation or metabolic deficits. Free neuropathology, 1, 1-33.

Profile Details

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