Dr. Lanrong Bi

Chemistry Department
Michigan Technological University, USA

Associate Professor

Email: [email protected]

Qualifications

2005 Postdoctoral, Genomic Engineering, Columbia University, USA
2004 Postdoctoral, Chemical Biology, City University of New York, USA
2002 Postdoctoral, Medicinal Chemistry, National Center for Scientific Research, France
2000 Ph.D., Pharmaceutical Sciences, Peking University, China
1995 M.Sc., Organic Chemistry, HeBei Normal University, China
1992 B.Sc., Chemistry, HeBei Normal University, China

Publications (selected)

1. Wang, Renjun & Wang, Min & Du, Dongshu & Shan, Zhiying & Bi, Lanrong & Chen, Qing-Hui. (2025). Brain-Targeted Reactive Oxygen Species in Hypertension: Unveiling Subcellular Dynamics, Immune Cross-Talk, and Novel Therapeutic Pathways. Antioxidants. 14. 408. 10.3390/antiox14040408. 
2. Chen, Xinqian & Yan, Xin & Yu, Chunxiu & Chen, Qing-hui & Bi, Lanrong & Shan, Zhiying. (2024). PTSD Increases Risk for Hypertension Development Through PVN Activation and Vascular Dysfunction in Sprague Dawley Rats. Antioxidants. 13. 1423. 10.3390/antiox13111423. 
3. Hou, Shanshan & Yan, Xin & Gao, Xiang & Jockusch, Steffen & Gibson, K. & Shan, Zhiying & Bi, Lanrong. (2024). Enhancing Cardiomyocyte Resilience to Ischemia-Reperfusion Injury: The Therapeutic Potential of an Indole-Peptide-Tempo Conjugate (IPTC). ACS Omega. 9. 10.1021/acsomega.4c02725. 
4. Mandalapu, Srinivas & Hou, Shanshan & Bi, Lanrong & Jockusch, Steffen & Shan, Zhiying. (2024). A novel class of indole derivatives: enhanced bioavailability, permeability, and antioxidant efficacy for thromboembolic disease therapy. Medicinal Chemistry Research. 33. 1-6. 10.1007/s00044-024-03277-1. 
5. Chen, Xinqian & Yan, Xin & Bi, Lanrong & Chen, Qinghui & Shan, Zhiying. (2024). Brain-Derived Extracellular Vesicles from Dahl Salt-Sensitive Rats with High Salt Diet Increase PVN and SON Vasopressin Levels in Sprague Dawley rats. Physiology. 39. 10.1152/physiol.2024.39.S1.1262. 
6. Chen, Xinqian & Yan, Xin & Gingerich, Leah & Chen, Qing-Hui & Bi, Lanrong & Shan, Zhiying. (2024). Induction of Neuroinflammation and Brain Oxidative Stress by Brain-Derived Extracellular Vesicles from Hypertensive Rats. Antioxidants. 13. 328. 10.3390/antiox13030328. 
7. Yan, Xin & Chen, Xinqian & Shan, Zhiying & Bi, Lanrong. (2024). Innovative Cyanine-Based Fluorescent Dye for Targeted Mitochondrial Imaging and Its Utility in Whole-Brain Visualization. ACS Omega. 9. 10.1021/acsomega.3c07374. 
8. Yan, Xin & Chen, Xinqian & Shan, Zhiying & Bi, Lanrong. (2023). Engineering Exosomes to Specifically Target the Mitochondria of Brain Cells. ACS Omega. 8. 10.1021/acsomega.3c06617. 
9. Chen, Xinqian & Yan, Xin & Gingerich, Leah & Chen, Qinghui & Bi, Lanrong & Shan, Zhiying. (2023). Brain-Derived Small Extracellular Vesicles from Dahl Salt-Sensitive Rats with High Salt Diet Induce Inflammation and Oxidative Stress. Physiology. 38. 10.1152/physiol.2023.38.S1.5730523. 
10. Yapici, Nazmiye & Gao, Xiang & Yan, Xin & Hou, Shanshan & Jockusch, Steffen & Lesniak, Lillian & Gibson, K. & Bi, Lanrong. (2021). Novel Dual-Organelle-Targeting Probe (RCPP) for Simultaneous Measurement of Organellar Acidity and Alkalinity in Living Cells. ACS Omega. XXXX. 10.1021/acsomega.1c03087. 
11. Bi, Wei & Bi, Yue & Li, Pengfei & Hou, Shanshan & Yan, Xin & Hensley, Connor & Zhang, Yanrong & Jockusch, Steffen & Legalley, Thomas & Gibson, K. & Bi, Lanrong. (2019). Cardioprotection Effects of LPTC-5 Involve Mitochondrial Protection and Dynamics. ACS Omega. 4. 9868-9877. 10.1021/acsomega.8b02441. 
12. Bi, Wei & Bi, Yue & Li, Pengfei & Hou, Shanshan & Yan, Xin & Hensley, Connor & Bammert, Catherine & Zhang, Yanrong & Gibson, K. & Ju, Jingfang & Bi, Lanrong. (2018). Indole Alkaloid Derivative B, a Novel Bifunctional Agent That Mitigates 5-Fluorouracil-Induced Cardiotoxicity. ACS Omega. 3. 15850-15864. 10.1021/acsomega.8b02139. 
13. Bi, Wei & Bi, Yue & Gao, Xiang & Li, Pengfei & Hou, Shanshan & Zhang, Yanrong & Bammert, Cathy & Jockusch, Steffen & Legalley, Thomas & Gibson, K. & Bi, Lanrong. (2017). Indole-TEMPO conjugates alleviate ischemia-reperfusion injury via attenuation of oxidative stress and preservation of mitochondrial function. Bioorganic & Medicinal Chemistry. 25. 10.1016/j.bmc.2017.03.033. 
14. Bi, Wei & Bi, Yue & Gao, Xiang & Li, Pengfei & Hou, Shanshan & Zhang, Yanrong & Bammert, Cathy & Jockusch, Steffen & Legalley, Thomas & Gibson, K. & Bi, Lanrong. (2017). Indole-TEMPO conjugates alleviate ischemia-reperfusion injury via attenuation of oxidative stress and preservation of mitochondrial function. Bioorganic & Medicinal Chemistry. 25. 10.1016/j.bmc.2017.03.033. 
15. Bi, Wei & Bi, Yue & Gao, Xiang & Yan, Xin & Zhang, Yanrong & Harris, Jackie & Legalley, Thomas & Gibson, K & Bi, Lanrong. (2016). Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury. Bioorganic & Medicinal Chemistry Letters. 26. 10.1016/j.bmcl.2016.06.079. 
16. Bi, Wei & Bi, Yue & Gao, Xiang & Yan, Xin & Zhang, Yanrong & Xue, Ping & Bammert, Catherine & Legalley, Thomas & Gibson, K. & Bi, Lanrong & Wang, Jia-Xiang. (2016). Anti-inflammatory, analgesic and antioxidant activities of novel kyotorphin-nitroxide hybrid molecules. Bioorganic & Medicinal Chemistry Letters. 26. 10.1016/j.bmcl.2016.02.086. 
17. Bi, Wei & Bi, Yue & Gao, Xiang & Yan, Xin & Zhang, Yanrong & Harris, Jackie & Legalley, Thomas & Gibson, K & Bi, Lanrong. (2016). Pharmacological protection of mitochondrial function mitigates acute limb ischemia/reperfusion injury. Bioorganic & Medicinal Chemistry Letters. 26. 10.1016/j.bmcl.2016.06.079. 
18. Bi, Wei & Bi, Yue & Gao, Xiang & Yan, Xin & Zhang, Yanrong & Xue, Ping & Bammert, Catherine & Legalley, Thomas & Gibson, K. & Bi, Lanrong & Wang, Jia-Xiang. (2016). Anti-inflammatory, analgesic and antioxidant activities of novel kyotorphin-nitroxide hybrid molecules. Bioorganic & Medicinal Chemistry Letters. 26. 10.1016/j.bmcl.2016.02.086. 
19. Yapici, Nazmiye & Mandalapu, Srinivas & Gibson, K. & Bi, Lanrong. (2015). Targeted fluorescent probes for detection of oxidative stress in the mitochondria. Bioorganic & medicinal chemistry letters. 25. 10.1016/j.bmcl.2015.07.011. 
20. Chen, Xin & Bi, Yue & Wang, Tianyang & Li, Pengfei & Yan, Xin & Hou, Shanshan & Bammert, Catherine & Ju, Jingfang & Gibson, K & Pavan, William & Bi, Lanrong. (2015). Lysosomal Targeting with Stable and Sensitive Fluorescent Probes (Superior LysoProbes): Applications for Lysosome Labeling and Tracking during Apoptosis. Scientific reports. 5. 9004. 10.1038/srep09004. 

Profile Details

https://www.mtu.edu/chemistry/people-groups/faculty-staff/faculty/bi/