Prof. Manijeh Pasdar

University of Alberta, Canada

Email: [email protected]

Qualifications

1984 Ph.D., University of Illinois, Genetics

1974 M.Sc., Pahlavi University, Animal Breeding

1971 B.Sc., Pahlavi University, Animal Science

Publications (selected)

1. Lo, C. S., Alavi, P., Bassey-Archibong, B., et al. (2024). Differential effect of plakoglobin in restoring the tumor suppressor activities of p53-R273H vs. p53-R175H mutants. PLOS ONE, 19(10), Article e0306705.
2. Nakhaei-Nejad, M., Trinity, L., Jabbari, H., et al. (2021). In Silico Analysis to Explore Lineage-Independent and -Dependent Transcriptional Programs Associated with the Process of Endothelial and Neural Differentiation of Human Induced Pluripotent Stem Cells. Journal of Clinical Medicine, 10(18), Article 4161.
3. Alaee, M., Nool, K., & Pasdar, M. (2018). Plakoglobin restores tumor suppressor activity of p53R175H mutant by sequestering the oncogenic potential of β-catenin. Cancer Science, 109(6), 1876–1888.
4. Tilli, T. M., Carels, N., Tuszynski, J. A., et al. (2018). Validation of a network-based strategy for the optimization of combinatorial target selection in breast cancer therapy. Clinical Cancer Research, 24(1), 86.
5. Aktary, Z., Alaee, M., & Pasdar, M. (2017). Beyond cell-cell adhesion: Plakoglobin and the regulation of tumorigenesis and metastasis. Oncotarget, 8(19), 32270–32291.
6. Tilli, T. M., Carels, N., Tuszynski, J. A., et al. (2016). Validation of a network-based strategy for the optimization of combinatorial target selection in breast cancer therapy: siRNA knockdown of network targets in MDA-MB-231 cells as an in vitro model for inhibition of tumor development. Oncotarget, 7(39), 63189–63203.
7. Minu, M., Singh, D., Mahaddalkar, T., et al. (2016). Chemical synthesis, pharmacological evaluation and in silico analysis of new 2,3,3a,4,5,6-hexahydrocyclopenta[c]pyrazole derivatives as potential anti-mitotic agents. Bioorganic & Medicinal Chemistry Letters, 26(16), 3855–3861.
8. Alaee, M., Danesh, G., & Pasdar, M. (2016). Plakoglobin Reduces the in vitro Growth, Migration and Invasion of Ovarian Cancer Cells Expressing N-Cadherin and Mutant p53. PLOS ONE, 11(5), Article e0154323.
9. Alaee, M., Padda, A., Mehrabani, V., et al. (2016). The physical interaction of p53 and plakoglobin is necessary for their synergistic inhibition of migration and invasion. Oncotarget, 7(18), 26898–26915.
10. Aktary, Z., & Pasdar, M. (2013). Plakoglobin Represses SATB1 Expression and Decreases In Vitro Proliferation, Migration and Invasion. PLOS ONE, 8(11), Article e78388.
11. Tang, Y. A., Mackey, J., Lai, R., et al. (2013). Quantitative proteomic analysis of HER2 normal and overexpressing MCF-7 breast cancer cells revealed proteomic changes accompanied with HER2 gene amplification. Journal of Proteomics, 91, 200–209.
12. Aktary, Z., Kulak, S., Mackey, J., et al. (2013). Plakoglobin interacts with the transcription factor p53 and regulates the expression of 14-3-3σ. Journal of Cell Science, 126(14), 3031–3032.
13. Aktary, Z., & Pasdar, M. (2012). Plakoglobin (β-catenin) interacts with the transcription factor p53 and regulates the expression of genes involved in tumorigenesis and metastasis. Cancer Research, 72(8), 1185.
14. Lam, L., Aktary, Z., Bishay, M., et al. (2012). Regulation of subcellular distribution and oncogenic potential of nucleophosmin by plakoglobin. Oncogenesis, 1, Article e4.
15. Pasdar, M. (2012). Molecular characterization of the growth regulating activities of plakoglobin (γ-catenin). Cellular Oncology, 35(1), S52–S53.
16. Asgarian, N., Hu, X. Y., Aktary, Z., et al. (2010). Learning to predict relapse in invasive ductal carcinomas based on the subcellular localization of junctional proteins. Breast Cancer Research and Treatment, 121(2), 527–538.
17. Aktary, Z., Chapman, K., Lam, L., et al. (2010). Plakoglobin interacts with and increases the protein levels of metastasis suppressor Nm23-H2 and regulates the expression of Nm23-H1. Oncogene, 29(14), 2118–2129.
18. Pasdar, M., Aktary, Z., & Lam, L. (2010). MOLECULAR CHARACTERIZATION OF THE TUMOR SUPPRESSOR ACTIVITY OF PLAKOGLOBIN (G-CATENIN) AND ITS ROLE IN REGULATION OF GROWTH CONTROL AND METASTATIC PATHWAYS. Cellular Oncology, 32(3), 190.
19. Lam, L., Hu, X. Y., Aktary, Z., et al. (2009). Tamoxifen and ICI 182,780 increase Bcl-2 levels and inhibit growth of breast carcinoma cells by modulating PI3K/AKT, ERK and IGF-1R pathways independent of ERα. Breast Cancer Research and Treatment, 118(3), 605–621.
20. Aktary, Z., Lo, A., Ji, C. J., et al. (2009). Plakoglobin interacts with and regulates the expression and stability of Nonmetastatic protein 23 (Nm23). Cancer Research, 69(9), 4355.

Profile Details
https://apps.ualberta.ca/directory/person/mpasdar
https://scholar.google.com/citations?user=B9tGYiMAAAAJ&hl=en
https://www.researchgate.net/profile/Manijeh-Pasdar

WOS ResearcherID: FOI-5773-2022