Dr. Jun Qi

Dana-Farber Cancer Institute, USA

Senior Research Scientist

Email: [email protected]

Qualifications

2006  Ph.D., Chemistry, University of Michigan, USA

2001  M.Sc., Chemistry, Wayne State University, USA

1993  B.Sc., Chemistry, Fudan University, China

Publications (selected)

1. Agius, M. P., Song, C., Liu, Q., et al. (2026). Pharmacological targeting of IRF4 as a therapeutic strategy for multiple myeloma. Nature Chemical Biology. Advance online publication.
2. Liang, T., Guan, X., Chan, A., et al. (2026). Structural basis for BD1-preferring 2,4-disubstituted pyrimidine BRDT inhibitors. Journal of Medicinal Chemistry, 69(9), 11088-11108.
3. Delahunty, I., Nance, S., Zhang, Y., et al. (2026). Dysregulated AKT signaling reprograms osteosarcoma to drive selective reliance on EP300. Cancer Research, 86(7, Suppl. S), Article 4024.
4. Gustafson, A., Nance, S., Gryder, B., et al. (2026). Synergistic targeting of EP300/CBP and EYA co-activators collapses the rhabdomyosarcoma core regulatory circuit. Cancer Research, 86(7, Suppl. S), Article 3500.
5. Shendy, N., Zhang, Y., Nance, S., et al. (2026). A genome derived non coding reporter of dynamic cancer cell state. Cancer Research, 86(7, Suppl. S), Article 385.
6. Chen, L., Zhu, L., Xiao, H., et al. (2026). Nutrient-driven histone acetylation underlies energy storage and mobilization. Molecular Metabolism, 106, Article 102344.
7. Kardian, A. S., Sun, H., Ippagunta, S., et al. (2026). Dominant clones leverage developmental epigenomic states to drive ependymoma. Nature, 652(8111). Advance online publication.
8. Song, C., Liu, Q., Wang, T., et al. (2026). Proteasome cap targeting chimeras for ubiquitination-independent targeted protein degradation. Angewandte Chemie-International Edition, 65(9). Advance online publication.
9. Hong, D. L., Lyu, Y., Nayak, R., et al. (2025). Loss of NOTCH2 creates a TRIM28-dependent vulnerability in small cell lung cancer. Developmental Cell, 60(24), 3462-3479.
10. Barreto-Galvez, A., Niljikar, M., Gagliardi, J. E., et al. (2025). EP300 deficiency leads to chronic replication stress mediated by defective replication fork protection. Nature Communications, 17(1), Article 475.
11. Likasitwatanakul, P., Li, Z., Doan, P., et al. (2025). Disarming colorectal plasticity: Dual HDAC1/2 inhibition reprograms tumor cell fate via H3K27ac-dependent differentiation. Molecular Cancer Therapeutics, 24(10, Suppl. S), Article C31.
12. St Laurent, J. D., Xu, G. D., Ying, A. W., et al. (2025). Shifted assembly and function of mSWI/SNF family subcomplexes underlie targetable dependencies in dedifferentiated endometrial carcinomas. Nature Genetics, 57(11). Advance online publication.
13. Godfrey, L. C., Regalado, B., Schweber, S. R., et al. (2025). p300/CBP is an essential driver of pathogenic enhancer activity and gene expression in Ewing sarcoma. EMBO Reports, 26(19), 4766-4793.
14. Zhou, X., Moreira, S., Restelli, C., et al. (2025). Activation of a nongenetic AHR-ELMSAN1 axis optimizes BET-targeting therapy and suppresses leukemia stem cells in preclinical models. Science Translational Medicine, 17(810), Article eadn5400.
15. Liu, B. H., Liu, M., Radhakrishnan, S., et al. (2025). Targeting transcription factors through an IMiD independent zinc finger domain. EMBO Molecular Medicine, 17(6), 1393-1416.
16. Gritti, I., Wan, J., Weeresekara, V., et al. (2025). DNAJB1-PRKACA fusion drives fibrolamellar liver cancer through impaired SIK signaling and CRTC2/p300-mediated transcriptional reprogramming. Cancer Discovery, 15(2), 382-400.
17. Agius, M. P., Hevenor, L., Payne, N. C., et al. (2024). Pharmacological targeting of IRF4 as a therapeutic strategy for multiple myeloma. Blood, 144(Suppl. 1), 155-156.
18. Hassan, M. M., Li, Y. D., Ma, M. W., et al. (2024). Exploration of the tunability of BRD4 degradation by DCAF16 trans-labelling covalent glues. European Journal of Medicinal Chemistry, 279, Article 116904.
19. Duplaquet, L., So, K., Ying, A. W., et al. (2024). Mammalian SWI/SNF complex activity regulates POU2F3 and constitutes a targetable dependency in small cell lung cancer. Cancer Cell, 42(8). Advance online publication.
20. Li, Y. D., Ma, M. W., Hassan, M. M., et al. (2024). Template-assisted covalent modification underlies activity of covalent molecular glues. Nature Chemical Biology, 20(12). Advance online publication.

Profile Details

https://www.dana-farber.org/find-a-doctor/jun-qi
https://connects.catalyst.harvard.edu/profiles/display/Person/66299
https://scholar.google.com/citations?user=IHky_DIAAAAJ&hl=en

WOS ResearcherID: PIL-7897-2026