Prof. William J. Murphy

University of California, USA

Professor and Vice-Chair for Research

Email: [email protected]

Qualifications

1989 Ph.D., Univ of Texas Southwestern Med Center, Immunology

1984 B.S., Rutgers University, Biology

Publications (selected)

1. Sheng, M. K., & Murphy, W. J. (2026). Determinants of Chimeric Antigen Receptor (CAR) T Cell Success: In Vitro and In Vivo Preclinical Assessment. Cancers, 18(9), Article 1412.
2. Firoz, W. A., Collins, C. P., Vick, L. V., et al. (2026). Obesity exacerbates cytokine release syndrome (CRS) toxicity associated with chimeric antigen receptor (CAR) T cell therapy in preclinical models. Cancer Research, 86(7, Suppl. S), Article 1531.
3. Purl, M. C., Shick, A., Grimm, A., et al. (2026). Conformal external beam radiation increases B7-H3 expression in a murine model of pancreatic cancer liver metastases and promotes CAR T cell function. Cancer Research, 86(7, Suppl. S), Article 1527.
4. Sun, Y.-H., Vick, L., Van Dyke, J. E., et al. (2026). Development of a 32-color spectral flow cytometry panel for comprehensive immunophenotyping of PBMCs from cancer patients receiving immunotherapy and radiotherapy. Cancer Research, 86(7, Suppl. S), Article 6955.
5. Vick, L. V., Sun, Y.-H., Fan, M., et al. (2026). Overcoming reduced efficacy of fractionated radiotherapy in obese mice. Cancer Research, 86(7, Suppl. S), Article 6606.
6. Collins, C. P., Dunai, C., Vick, L. V., et al. (2026). Age-driven shifts in T and NK cell responses amplify inflammation and coagulopathy during viral infection in mice and humans. Frontiers in Immunology, 17, Article 1712726.
7. Foley, M. N., Brookover, E., Tewes, M. E., & Murphy, W. J. (2026). A chromosome-level genome assembly of the Texas ocelot (Leopardus pardalis albescens). Journal of Heredity, 117(2), 267-271.
8. Lord, K. A., Larson, G., Murphy, W. J., & Ostrander, E. A. (2025). Genomic ancestry, behavior, and the domestication of the dog. Proceedings of the National Academy of Sciences of the United States of America, 122(48), Article e2528616122.
9. Chislock, E. M., Pan, T.-c., Pant, D., et al. (2025). DTC-Flow: a flow cytometry-based detection platform for characterizing bone marrow disseminated tumor cells in breast cancer. npj Breast Cancer, 11(1), Article 139.
10. Foley, M. N., Rasulis, R. G., Wani, Z., et al. (2026). An ancient recombination desert is a speciation supergene in placental mammals. Nature, 644(8099). Advance online publication.
11. Razmara, A. M., Lammers, M., Judge, S. J., et al. (2025). Comparative transcriptomic analysis of tumor- infiltrating canine natural killer cells and candidate biomarkers from first-in-dog NK immunotherapy trials. Frontiers in Immunology, 16, Article 1646849.
12. Rebhun, R. B., Cruz, M. S., York, D., et al. (2025). Phase 2 trial (NCI-COTC030) of adjuvant inhaled recombinant human IL-15 combined with amputation and adjuvant chemotherapy in dogs with appendicular osteosarcoma. Frontiers in Immunology, 16, Article 1672790.
13. Burbrink, F. T., DeBaun, D., Foley, M. N., & Murphy, W. J. (2025). Recombination-aware phylogenomics. Trends in Ecology & Evolution, 40(9), 900-912.
14. Harris, A. J., Raudsepp, T., Foley, M. N., et al. (2025). Near-gapless genome assemblies of the domestic cat (Felis silvestris catus) and the African serval (Leptailurus serval) derived from trio-binning. Journal of Heredity, 116(6), 818-825.
15. Myers, L. S., Christian, S. G., Simpson, S., et al. (2025). A preclinical pig model of Angelman syndrome mirrors the early developmental trajectory of the human condition. Proceedings of the National Academy of Sciences of the United States of America, 122(30), Article e2505152122.
16. Razmara, A. M., Lammers, M., Judge, S. J., et al. (2025). Single cell atlas of canine natural killer cells identifies distinct circulating and tissue resident gene profiles. Frontiers in Immunology, 16, Article 1571085.
17. Gulati, S., & Murphy, W. J. (2025). Defining obesity in the context of cancer: thinking beyond body mass index. Trends in Cancer, 11(5), 441-447.
18. Santos, S. H. D., Figueiró, H., Flouri, T., et al. (2025). Massive Inter-species Introgression Overwhelms Phylogenomic Relationships Among Jaguar, Lion, and Leopard. Systematic Biology, 74(4), 583-599.
19. Firoz, W., Sheng, M. K., Vick, L., et al. (2025). CAR negative T cells predominate during xenogeneic graft versus host disease after CAR T cell treatment in NSG mice. Cancer Research, 85(8, Suppl. 1), Article 4817.
20. Purl, M., Mukarrama, T., Kim, J., et al. (2025). Targeting pancreas cancer liver metastases with B7-H3 tri-specific killer engager and regional delivery of placental-derived NK cellular therapy Free. Cancer Research, 85(8, Suppl. 1), Article 877.

Profile Details

https://health.ucdavis.edu/dermatology/faculty/murphy.html
https://scholar.google.com/citations?user=fVM2sOcAAAAJ&hl=en

WOS ResearcherID：OHC-2879-2025