Prof. Mahvash Zakikhani

McGill University, Canada

Email: [email protected]

Qualifications

1999 Ph.D., McGill University, Parasitology

1990 M.Sc., University of Tehran, Entomology and Epidemiology

1988 B.Sc., National University, Biology

Publications (selected)

1. Liu, J. L., Alami, T., Zakikhani, M., et al. (2023). Sexually dimorphic responses in obesity, glucose tolerance and diabetes caused by CCN5/ WISP2 gene deficiency and adipocyte-specific overexpression. Diabetologia, 66(Suppl 1), S287.
2. Grunbaum, A., Rozza, N., Zakikhani, M., et al. (2022). Vitamin D Deficiency is a Significant Risk Factor for Developing COVID-19 Manifestations Severe Enough to Require Hospitalization and is Associated with Elevated IL-8 & Worse Clinical Outcomes. Journal of Bone and Mineral Research, 37(Suppl 1), 237.
3. Li, J. R., Camirand, A., Zakikhani, M., et al. (2020). Therapeutic antibodies against parathyroid hormone-related peptide (PTHrP) inhibit the growth of established skeletal metastasis in mice transplanted with human triple negative breast cancer cell lines. Cancer Research, 80(16 Suppl), Meeting Abstract 520.
4. Li, J. R., Mihalcioiu, M., Li, L. F., et al. (2018). Vitamin D prevents lipid accumulation in murine muscle through regulation of PPARγ and perilipin-2 expression. Journal of Steroid Biochemistry and Molecular Biology, 177(SI), 116–124.
5. Yancu, D., Blouin, M. J., Birman, E., et al. (2017). A phenotype of IGFBP-3 knockout mice revealed by dextran sulfate-induced colitis. Journal of Gastroenterology and Hepatology, 32(1), 146–153.
6. Blouin, M. J., Bazile, M., Birman, E., et al. (2015). Germ line knockout of IGFBP-3 reveals influences of the gene on mammary gland neoplasia. Breast Cancer Research and Treatment, 149(3), 577–585.
7. Gravel, S. P., Hulea, L., Toban, N., et al. (2014). Serine Deprivation Enhances Antineoplastic Activity of Biguanides. Cancer Research, 74(24), 7521–7533.
8. Pollak, M. N., Blouin, M. J., Vasilevsky, C. A., et al. (2013). Metformin and biomarkers relevant to neoplasia in nondiabetic patients. Journal of Clinical Oncology, 31(15 Suppl), Abstract e14615.
9. Blouin, M. J., Birman, E., Zhao, Y. H., et al. (2013). The hyperinsulinemia caused by PI3K inhibitors attenuates their antineoplastic efficacy, but can be minimized by co-administration of metformin. Cancer Research, 73(8 Suppl 1), Meeting Abstract 4615.
10. Javeshghani, S., Zakikhani, M., Austin, S., et al. (2012). Carbon Source and Myc Expression Influence the Antiproliferative Actions of Metformin. Cancer Research, 72(23), 6257–6267.
11. Zakikhani, M., Bazile, M., Hashemi, S., et al. (2012). Alterations in Cellular Energy Metabolism Associated with the Antiproliferative Effects of the ATM Inhibitor KU-55933 and with Metformin. PLOS ONE, 7(11), Article e49513.
12. Dool, C. J., Mashhedi, H., Zakikhani, M., et al. (2011). IGF1/insulin receptor kinase inhibition by BMS-536924 is better tolerated than alloxan-induced hypoinsulinemia and more effective than metformin in the treatment of experimental insulin-responsive breast cancer. Endocrine-Related Cancer, 18(6), 699–709.
13. Mashhedi, H., Blouin, M. J., Zakikhani, M., et al. (2011). Metformin abolishes increased tumor 18F-2-fluoro-2-deoxy-D-glucose uptake associated with a high-energy diet. Cell Cycle, 10(16), 2770–2778.
14. Dool, C., Mashhedi, H., Zakikhani, M., et al. (2011). Insulin receptor kinase inhibition is better tolerated than hypoinsulinemia and more effective than metformin in treating breast cancer. Cancer Research, 71(8 Suppl), Meeting Abstract 2300.
15. Inoue, T., Zakikhani, M., Mireuta, M., et al. (2011). IN VIVO CASTRATION-RESISTANT ACCELERATION OF PROSTATE CANCER INHIBITED BY A SMALL MOLECULE INHIBITOR OF INSULIN-LIKE GROWTH FACTOR 1 RECEPTOR/ INSULIN RECEPTOR TYROSINE KINASE. Journal of Urology, 185(4 Suppl), Abstract 420.
16. Algire, C., Amrein, L., Bazile, M., et al. (2011). Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo. Oncogene, 30(10), 1174–1182.
17. Inoue, T., Zakikhani, M., David, S., et al. (2010). Effects of Castration on Insulin Levels and Glucose Tolerance in the Mouse Differ From Those in Man. Prostate, 70(15), 1628–1635.
18. Zakikhani, M., Blouin, M. J., Piura, E., & Pollak, M. N. (2010). Metformin and rapamycin have distinct effects on the AKT pathway and proliferation in breast cancer cells. Breast Cancer Research and Treatment, 123(1), 271–279.
19. Algire, C., Amrein, L., Zakikhani, M., et al. (2010). Metformin blocks the stimulative effect of a high-energy diet on colon carcinoma growth in vivo and is associated with reduced expression of fatty acid synthase. Endocrine-Related Cancer, 17(2), 351–360.
20. Blouin, M. J., Bazile, M., Zakikhani, M., & Pollak, M. (2010). IGFBP-3 knockout mice develop earlier mammary tumours following dimethylbenz[a]anthracene treatment. EJC Supplements, 8(5), Abstract 425.

Profile Details
https://www.researchgate.net/profile/Mahvash-Zakikhani
http://www.aus-canprostatealliance.org/Members/mahvash.zakikhani-40mail.mcgill.ca

WOS ResearcherID: CJN-3701-2022