Dr. Abbes Belkhiri

Vanderbilt University Medical Center, USA

Email: [email protected]

Qualifications

1995 Ph.D., University of Manitoba, Microbiology

1988 M.Sc., University of Reading, Reading

Publications (selected)

1. Zhu, S. M., Soutto, M., Chen, Z., et al. (2024). Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells (vol 38, pg 5805, 2019). Oncogene, 43(3), 224–224.
2. Lu, H., Cao, L. L., Ballout, F., et al. (2024). Reflux conditions induce E-cadherin cleavage and EMT via APE1 redox function in oesophageal adenocarcinoma. Gut, 73(1), 47–62.
3. Pidkovka, N., & Belkhiri, A. (2023). Altered expression of AXL receptor tyrosine kinase in gastrointestinal cancers: a promising therapeutic target. Frontiers in Oncology, 13, Article 1079041.
4. Lu, H., Cao, L. L., Ballout, F., et al. (2023). REFLUX CONDITIONS-INDUCED E-CADHERIN CLEAVAGE AND EPITHELIAL-TO-MESENCHYMAL TRANSITION IS MEDIATED BY APE1 REDOX FUNCTION IN ESOPHAGEAL ADENOCARCINOMA. Gastroenterology, 164(6, Suppl. S), S1011–S1011.
5. Lu, H., Cao, L. L., Ballout, F., et al. (2023). Gastroesophageal reflux disease promotes E-cadherin cleavage and activates EMT via APE1-redox function in esophageal adenocarcinoma. Cancer Research, 83(7, Suppl. S), Abstract 1232.
6. Hong, J., Maacha, S., Pidkovka, N., et al. (2022). AXL Promotes Metformin-Induced Apoptosis Through Mediation of Autophagy by Activating ROS-AMPK-ULK1 Signaling in Human Esophageal Adenocarcinoma. Frontiers in Oncology, 12, Article 903874.
7. Lu, H., Belkhiri, A., Peng, DF., et al. (2021). APE1 REDOX FUNCTIONS MEDIATE E-CADHERIN CLEAVAGE AND EMT IN RESPONSE TO EXPOSURE TO ACIDIC BILE SALTS IN ESOPHAGEAL ADENOCARCINOMA. Gastroenterology, 160(6, Suppl. S), S241–S241.
8. Hong, J., Abid, F., Phillips, S., et al. (2020). Co-overexpression of AXL and c-ABL predicts a poor prognosis in esophageal adenocarcinoma and promotes cancer cell survival. Journal of Cancer, 11(20), 5867–5879.
9. Lu, H., Bhat, A. A., Peng, D. F., et al. (2019). APE1 Upregulates MMP-14 via Redox-Sensitive ARF6-Mediated Recycling to Promote Cell Invasion of Esophageal Adenocarcinoma. Cancer Research, 79(17), 4426–4438.
10. Zhu, S. M., Soutto, M., Chen, Z., et al. (2019). Activation of IGF1R by DARPP-32 promotes STAT3 signaling in gastric cancer cells. Oncogene, 38(29), 5805–5816.
11. Soutto, M., Chen, Z., Bhat, A. A., et al. (2019). Activation of STAT3 signaling is mediated by TFF1 silencing in gastric neoplasia. Nature Communications, 10, Article 3039.
12. Lu, H., Bhat, A. A., Peng, D. F., et al. (2019). APE1 upregulates MMP-14 to promote invasion of esophageal adenocarcinoma via redox-sensitive ARF6-mediated recycling. Cancer Research, 79(13, Suppl. S), Abstract 157.
13. Hong, J., Maacha, S., & Belkhiri, A. (2018). Transcriptional upregulation of c-MYC by AXL confers epirubicin resistance in esophageal adenocarcinoma. Molecular Oncology, 12(12), 2191–2208.
14. Maacha, S., Hong, J., von Lersner, A., et al. (2018). AXL Mediates Esophageal Adenocarcinoma Cell Invasion through Regulation of Extracellular Acidification and Lysosome Trafficking. Neoplasia, 20(10), 1008–1022.
15. Bhat, A. A., Lu, H., Suotto, M., et al. (2018). Bile reflux-induced APE1 mediates activation of EGFR-STAT3 in barret's and esophageal adenocarcinoma cells. Cancer Research, 78(13, Suppl. S), Abstract LB-396.
16. Hong, J., Maacha, S., & Belkhiri, A. (2018). AXL PROMOTES EPIRUBICIN RESISTANCE THROUGH REGULATION OF C-MYC IN ESOPHAGEAL ADENOCARCINOMA. Gastroenterology, 154(6, Suppl. 1), S50–S51.
17. Maacha, S., Hong, J., von Lersner, A., et al. (2018). AXL RECEPTOR TYROSINE KINASE MEDIATES ESOPHAGEAL ADENOCARCINOMA CELL INVASION VIA REGULATION OF LYSOSOME TRAFFICKING. Gastroenterology, 154(6, Suppl. 1), S672–S672.
18. Soutto, M., Chen, Z., Bhat, A., et al. (2018). TFF1 SUPPRESSES IL-6 MEDIATED STAT3 ACTIVATION THROUGH INTERFERING WITH IL6Rα/GP130 COMPLEX FORMATION. Gastroenterology, 154(6, Suppl. 1), S22–S22.
19. Zhu, S. M., Chen, Z., Wang, L. H., et al. (2018). A Combination of SAHA and Quinacrine Is Effective in Inducing Cancer Cell Death in Upper Gastrointestinal Cancers. Clinical Cancer Research, 24(8), 1905–1916.
20. Wang, L. H., Arras, J., Katsha, A., et al. (2017). Cisplatin-resistant cancer cells are sensitive to Aurora kinase A inhibition by alisertib. Molecular Oncology, 11(8), 981–995.

Profile Details
https://www.researchgate.net/profile/Abbes-Belkhiri
https://loop.frontiersin.org/people/1518195/overview

WOS ResearcherID: CFU-7211-2022