Prof. Cosmas O. Okoro

Tennessee State University, USA

Email: [email protected]

Qualifications

2000 Postdoctor, Medicinal Chemistry, University of Kansas, USA

1995 Postdoctor, Medicinal Chemistry, Florida A&M University, USA

1993 Ph.D., Organic Chemistry, Howard University, USA

1986 B.Sc., Chemistry, North Carolina Central University, USA

Publications (selected)

1. Oyedele, Abiodun Samuel & Fatoki, Toluwase & Dalvie, Esha & Osheroff, Neil & Okoro, Cosmas. (2023). Synthesis, SAR, and in Silico ADME Screening Studies of Some 9-Amino-3-Phenylacridone Derivatives as Topoisomerase II Inhibitors. Open Journal of Medicinal Chemistry. 13. 15-34. 10.4236/ojmc.2023.132002. 
2. Cosmas O. Okoro and Toluwase H. Fatoki. A mini Review of Novel Topoisomerase II Inhibitors as Future Anticancer Agents. Int.J.Mol. Sci. 2023, 24, 2532
3. Oyedele, Abiodun S.; Bogan, Deanna N.; Okoro, Cosmas O. Synthesis, biological evaluation and virtual screening of some acridone derivatives as potential anticancer agents, Bioorganic & Medicinal Chemistry (2020), 28(9), 115426. Language: English, Database: CAPLUS
4. Oyedele, Abiodun S.; Dalvie, Esha D.; Osheroff, Neil; Okoro, Cosmas Obi. Novel 9-amino acridone derivatives as potential topoisomerase II inhibitors, Abstracts of Papers, 259th ACS National Meeting & Exposition, Philadelphia, PA, United States, March 22-26, 2020 (2020), MEDI-0205. Language: English, Database: CAPLUS
5. Oyedele, Abiodun Samuel S.; Okoro, Cosmas O. Synthesis and virtual screening of novel acridone derivatives as potential topoisomerase II α catalytic inhibitors. Abstracts, 71st Southeastern Regional Meeting of the American Chemical Society, Savannah, GA, United States, October 20-23 (2019), SERMACS-777.   Language: English, Database: CAPLUS
6. Cosmas O. Okoro., Mumiye A. Ogunwale, Abiodun S. Oyedele. Facile Synthesis of bis-trifluoromethyl-1,8-dioxo-octahydroxanthene derivatives. International J. of Org. Chem. 2019, 9, 121-129.
7. John Apraku and Cosmas O. Okoro. Design, synthesis and anticonvulsant evaluation of fluorinated benzyl amino enaminones.  Bioorg & Med. Chem. 27 (2019) 161-166
8. Lorena Ifante, Alexis Sledge, Amine Laradji, Cosmas O. Okoro, and Neil Osheroff. Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1 (2H)-ones act as covalent poison of human topoisomerase IIα. Bioorg. & Med. Chem. Lett. 27, (2017) 586-589.
9. Chibuike D. Obi, Cosmas O. Okoro. Synthesis of 5-(trifluoromethyl)cyclohexane-1,2,3-trione (cVTC): new trifluoromethyl building block.  Tetrahedron letters 57 (2016), 5259-5261.
10. Cosmas O. Okoro, John Apraku, Elisha Okoromoba, and Olugbeminiyi O. Fadeyi, Synthesis and Anticonvulsant Activity of Fluorinated Cyclic Enaminones.  Letters in Drug Design & Discovery, 2013, 10, 1024-1031.
11. Saudat A. Fadeyi, Olugbeminiyi O. Fadeyi, Adedeji A. Adejumo, Cosmas O. Okoro and Elbert L. Myles, In Vitro anticancer screening of 24 locally used Nigerian medicinal plants, BMC Complementary and Alternative Medicine 2013, 13:79
12. Adeayo O. Ajala and Cosmas O. Okoro, “CoMFA and CoMSIA studies on fluorinated hexahydropyrimidine derivatives”. Bioorganic & Medicinal Chemistry Letters 21 (2011) 7392-7398.
13. Oluropo C. Agbaje, Olugbeminiyi O. Fadeyi, and Cosmas O. Okoro, “Lewis Acid Mediated Diastereoselective Synthesis of Fused Fluorinated Spiroketal as potential Biologically Active Compounds. Tetrahedron Letters (2011), doi: 10.1016/j.tetlet.2011.08.004.
14. Cosmas O. Okoro, Tasneem Siddiquee, and Olugbeminiyi O. Fadeyi. 5,7-Dibromo-3-trifluoromethyl-3,4-dihydroacridin-1 (2H)-one.Acta Cryst. (2011). E67, o2052
15. Mumini, Hadijatu; Okoro, Cosmas.  Synthesis and antitumor activity evaluation of some trifluoromethylated indolones.  Abstracts of Papers, 241st ACS National Meeting & Exposition, Anaheim, CA, United States, March 27-31, 2011 (2011), ORGN-735. CODEN: 69NZUR. AN 2011:339200 CAPLUS
16. Ogunwale, Mumiye A.; Okoro, Cosmas C. Synthesis of novel trifluoromethylated hexahydroquinoline derivatives as potential calcium channel modulators.  Abstracts of Papers, 241st ACS National Meeting & Exposition, Anaheim, CA, United States, March 27-31, 2011 (2011), MEDI-142. CODEN: 69NZUR.  AN 2011:338179 CAPLUS
17. Oluropo C. Agbaje, Olugbeminiyi O. Fadeyi, S. Adamson Fadeyi, Lewis E. Myles, Cosmas O. Okoro. Synthesis and in vitro cytotoxicity of some fluorinated hexahydropyrimidine derivatives. Bioorganic & Medicinal Chemistry Letters 21 (2011) 989-992.
18. Olugbeminiyi O. Fadeyi, Saudat T. Adamson, E. Lewis Myles, Cosmas O. Okoro. Novel fluorinated acridone derivatives. Part 1: Synthesis and evaluation as potential anticancer agents. Bioorganic & Medicinal Chemistry Letters 18 (2008) 4172-4176.
19. Olugbeminiyi O. Fadeyi, Cosmas O. Okoro. Synthesis of 5-(trifluoromethyl)cyclohexane-1,3-dione and 3-amino-5-(trifluoromethyl)cyclohex-2-en-1-one: new trifluoromethylbuilding block. Tetrahedron Lett. 49 (2008) 4725-4727.
20. Fadeyi, Olugbeminiyi O.; Wash, Kendra;Okoro, Cosmas O. Synthesis of fluorinated dihydropyrazolo-pyrimidinederivatives as potential biologically active compounds. Abstracts of Papers, 233rd ACS National Meeting, Chicago, IL, United States, March 25-29, 2007 (2007),MEDI-408. CODEN: 69JAUY AN 2007:295837 CAPLUS.

Profile Details

https://www.tnstate.edu/FACULTY/COKORO/