Dr. Tatsuya Kin

Clinical Islet Laboratory

University of Alberta/ Alberta Health Services, Canada

Technical Director

Email: [email protected]

Qualifications

2003 Ph.D., Nara Medical University, Japan

1992 General Surgeon certified by Japanese Surgical Society, Japan

1988 Doctor of Medicine, Nara Medical University, Japan

Publications (selected)

1. Inoue, R., Tajima, K., Okuyama, T., Sakai, C., Kanno, T., Zou, M., Kyohara, M. and others. Metformin suppresses β-cell apoptosis under ER stress by inhibiting protein translation. Metabolism, 156607, 2026.  
2. Huang, L.T., Gao, R.J., Zhang, D., Nian, C., Martzke, W., Shapiro, A.M.J., Kin, T. and others. Truncated CD19 as a selection marker for the isolation of stem cell-derived β-cells. Disease Models & Mechanisms, 19(1), dmm052376, 2026.  
3. Czarnecka, Z., Verhoeff, K., Carr, A.L.F., Lam, A., Senior, P., Lucciantonio, R. and others. Glycemic control and risk of recurrent hypoglycemia after total pancreatectomy. Canadian Journal of Surgery, 68, S47, 2025.  
4. Karampelias, C., Yang, K., Farkas, F.J., Sterr, M., van Den Bosch, M.M. and others. Benchmarking porcine pancreatic ductal organoids for drug screening applications. EMBO Molecular Medicine, 17(12), 3657, 2025.  
5. Yabe, S.G., Nishida, J., Fukuda, S., Kin, T., Nishiyama, A., Tamura, T., Takeda, F. and others. High glucose burden disrupts the glucose responsiveness of human pancreatic beta cells encapsulated in alginate fibers during Long-Term culture. Gene, 964, 149639, 2025.  
6. Inoue, R., Tsuno, T., Nishimura, T., Fukushima, S., Hirai, S., Shimoda, M. and others. Adenylosuccinate Mediates Imeglimin-Induced Proliferative and Antiapoptotic Effects in β-Cells. Diabetes, 74(9):1589-1602, 2025.  
7. Tsuno, T., Li, J., Nishiyama, K., Kawasawa, Y.I., Inoue, R., Yajima, E.O. and others. Imeglimin suppresses glucagon secretion and induces a loss of α cell identity. Cell Reports Medicine, 6(8), 2025.  
8. Czarnecka, Z., Verhoeff, K., Carr, A.L.J., Lam, A., Senior, P., Lucciantonio, R. and others. Risk of recurrent hypoglycemia and long-term survival after total pancreatectomy: a prospective observational study. Annals of Surgery, 10.1097, 2025.  
9. Carr, A.L.J., Shah, R., Marfil-Garza, B.A., Lam, A., Dajani, K., Anderson, B. and others. Sequential islet transplants for type 1 diabetes are not associated with sustained or cumulative increases in hepatic portal venous pressure. Plos One, 20(7), e0329074, 2025.  
10. Okuyama, T., Tsuno, T., Inoue, R., Fukushima, S., Kyohara, M., Matsumura, A. and others. The matricellular protein Fibulin-5 regulates β-cell proliferation in an autocrine/paracrine manner. iScience, 28(2), 2025.  
11. Lyon, J.G., Carr, A.L.J., Smith, N.P., Marfil-Garza, B., Spigelman, A.F., Bautista, A. and others. Human research islet cell culture outcomes at the Alberta Diabetes Institute IsletCore. Islets, 16(1), 2385510, 2024.  
12. Carr, A.L.J., Marfil-Garza, B., Lam, A., Dajani, K., Kin, T., Anderson, B. and others. Females undergoing islet transplantation using CNI-based immunosuppression may be at higher risk of progressing to reduced kidney function. Diabetologia, 67, S222, 2024.  
13. Imamura, H., Adachi, T., Miyamoto, D., Kin, T., Yamashita, M., Matsushima, H. and others. Analysis of Expression Status and Relationship Between Senescence-related Genes and Pancreatic Function-related Genes in Human Islets of Langerhans from Donors of Various Ages. In Vivo, 38(5):2165-2171, 2024.  
14. Parente, A., Verhoeff, K., Kin, T., Hefler, J., Marfil-Garza, B.A. and others. Evaluating islet cell isolation and transplantation from donors following medical assistance in dying. Transplantation Direct, 10(7), e1667, 2024.  
15. Carr, A.L.J., Marfil-Garza, B.A., Lam, A., Anderson, B.L., O'Gorman, D., Kin, T. and others. 336-OR: Females Undergoing Islet Transplantation with CNI-Based Immunosuppression May Be at Higher Risk of Renal Function Decline. Diabetes, 73(Supplement_1), 336-OR, 2024.  
16. Carr, A.L.J., Shah, R., Marfil-Garza, B.A., Lam, A., Anderson, B.L., O'Gorman, D. and others. 225-OR: Sequential Islet Transplants for Type 1 Diabetes Do Not Cumulatively Increase Hepatic Portal Venous Pressure. Diabetes, 73(Supplement_1), 225-OR, 2024.  
17. Kin, T., Noguchi, H. and Kawaguchi, A. Is Donation after Circulatory Determination of Death in Japan Uncontrolled or Controlled? OBM Transplantation, 8(2):1-12, 2024.  
18. Kin, T., O'Gorman, D., Zhai, W., Moriarty, J., Park, K., Ganguly, A., Rosichuk, S. and others. Contribution of a single islet transplant program to basic researchers in North America, Europe, and Asia through distributing human islets. OBM Transplantation, 8(2):1-15, 2024.  
19. Forbes, S., Halpin, A., Lam, A., Grynoch, D., Parker, R., Lidalgo, H., Bigam, D. and others. Islet transplantation outcomes in type 1 diabetes and transplantation of HLA-DQ8/DR4: results of a single-centre cohort in Canada. EClinicalMedicine, 67, 2024.  
20. Nishida, J., Tsuno, T., Yabe, S.G., Kin, T., Fukuda, S., Takeda, F., Shirakawa, J. and others. Encapsulated human islets in alginate fiber maintain long-term functionality. Endocrine Journal, 71(3):253-264, 2024.

Personal Details

https://apps.ualberta.ca/directory/person/tkin

https://scholar.google.com/citations?user=cZEDNb8AAAAJ&hl=en

https://www.researchgate.net/profile/Tatsuya-Kin

WoS Researcher ID: A-3776-2012